■先前的研究已经证实,甘油三酯葡萄糖(TyG)指数,被认为是胰岛素抵抗的可靠标志,是糖尿病肾病(DKD)的重要风险身分。然而,目前尚不清楚DKD风险是否随着TyG指数的升高而持续线性增加.本研究旨在深入研究TyG指数与2型糖尿病(T2D)DKD风险之间的内在关系。
■这项横断面研究纳入了中国933例T2D患者,将其分为DKD和非DKD组,并按TyG指数水平分层。Logistic回归分析确定了DKD的独立危险因素。使用受限三次样条(RCS)曲线分析评估DKD风险与TyG指数之间的关联。R包“CatPredi”用于确定DKD风险与TyG指数之间关系的最佳临界点,其次是阈值效应分析。
■DKD的患病率为33.01%。在调整混杂因素后,TyG指数被确定为DKD的突出临床危险因素,显示最高的赔率比(OR1.57(1.26-1.94),P<0.001)。RCS分析显示,TyG指数与DKD风险之间存在阈值区间效应的非线性关系。当TyG指数≤9.35时,DKD风险稳定在较低水平;然而,当TyG指数>9.35时,随着TyG指数的升高,DKD风险逐渐增加。在TyG指数>9.35的患者中,每增加1个单位与DKD风险增加1.94倍相关(OR=1.94(1.10-3.43),P=0.022)。
■随着TyG指数的增加,DKD风险呈现阈值效应,最初稳定在低水平,然后在TyG指数高于9.35时逐渐上升。
UNASSIGNED: Previous studies have confirmed that the triglyceride glucose (TyG) index, recognized as a reliable marker of insulin resistance, is an important risk factor for diabetic kidney disease (DKD). However, it is still unclear whether the DKD risk continues to increase linearly with the elevation of TyG index. This study aimed to thoroughly investigated the intrinsic relationship between TyG index and DKD risk in type 2 diabetes (T2D).
UNASSIGNED: This cross-sectional study included 933 patients with T2D in China, who were categorized into DKD and non-DKD groups and stratified by TyG index levels. Logistic regression analysis identified the independent risk factors for DKD. The association between DKD risk and TyG index was evaluated using the restricted cubic spline (RCS) curves analysis. The R package \'CatPredi\' was utilized to determine the optimal cut-off point for the relationship between DKD risk and TyG index, followed by threshold effect analysis.
UNASSIGNED: The prevalence of DKD was 33.01%. After adjusting for confounding factors, TyG index was identified as a prominent clinical risk factor for DKD, showing the highest odds ratio (OR 1.57 (1.26 - 1.94), P<0.001). RCS analysis revealed a non-linear relationship with a threshold interval effect between the TyG index and DKD risk. When TyG index ≤ 9.35, DKD risk plateaued at a low level; however, when TyG index > 9.35, DKD risk increased gradually with rising TyG index. Among patients with TyG index > 9.35, each 1-unit increase was associated with a 1.94-fold increased DKD risk (OR=1.94 (1.10 - 3.43), P=0.022).
UNASSIGNED: The DKD risk presented a threshold effect with the increase of TyG index, initially stable at a low level, and then gradually rising when the TyG index is above 9.35.