■母体色氨酸(TRP)代谢在母体健康和怀孕中的重要作用已经确立。然而,影响TRP代谢的非医学母体决定因素研究甚少。我们假设感知母体非医学决定因素会改变TRP代谢,影响犬尿氨酸(KP)和5-羟色胺途径(SP)代谢物浓度。因此,我们调查了非医学母体决定因素对围术期TRP代谢的影响。
■在2010年11月至2020年12月期间,鹿特丹预感队列中包括了大约1916例怀孕。通过问卷调查收集有关非医学产妇决定因素的数据。在妊娠8.5周(SD=1.6)和TRP时收集血清样本,犬尿氨酸(KYN),5-羟色氨酸(5-HTP),使用经验证的液相色谱(串联)质谱法测定5-HT(5-羟色胺)和5-羟基吲哚乙酸(5-HIAA)。混合模型用于确定观念非医学母体决定因素与这些代谢物之间的关联。
■总共确定了11个概念非医学母体决定因素。蛋白质摄入量与TRP呈正相关(β=.12,95%CI=0.07-0.17),而年龄,能量摄入和体重指数(BMI)(β=-.24,95%CI=-0.37至-0.10)与TRP呈负相关。年龄,BMI和总同型半胱氨酸与较高的KYN相关,而非西方地理来源与较低的KYN相关(β=-.09,95%CI=-0.16至-0.03)。蛋白质摄入量和总同型半胱氨酸(β=.07,95%CI=0.03-0.11)与5-HTP呈正相关,而能量摄入呈负相关。非西方地理来源和药物使用与较高的5-HT相关,BMI与5-HT较低(β=-6.32,95%CI=-10.26~-2.38)。年龄与5-HIAA呈正相关(β=0.92,95%CI=0.29-1.56),BMI消极。
■感知非医学产妇决定因素,包括年龄,地理起源,吸毒,能量和蛋白质的摄入,BMI和总同型半胱氨酸,影响KP和SP代谢物浓度。
UNASSIGNED: The vital role of the maternal tryptophan (TRP) metabolism in maternal health and pregnancy is well established. However, non-medical maternal determinants influencing the TRP metabolism have been poorly investigated. We hypothesise that periconceptional maternal non-medical determinants alter the TRP metabolism, affecting both kynurenine (KP) and serotonin pathway (SP) metabolite concentrations. Therefore, we investigated the influence of non-medical maternal determinants on the TRP metabolism during the periconception period.
UNASSIGNED: About 1916 pregnancies were included from the Rotterdam Periconceptional Cohort between November 2010 and December 2020. Data on periconceptional non-medical maternal determinants were collected through questionnaires. Serum samples were collected at 8.5 (SD = 1.6) weeks of gestation and TRP, kynurenine (KYN), 5-hydroxytryptophan (5-HTP), 5-HT (5-hydroxytryptamine) and 5-hydroxyindole acetic acid (5-HIAA) were determined using validated liquid chromatography (tandem) mass spectrometry. Mixed models were used to determine associations between periconceptional non-medical maternal determinants and these metabolites.
UNASSIGNED: In total 11 periconceptional non-medical maternal determinants were identified. Protein intake was positively associated with TRP (β = .12, 95% CI = 0.07-0.17), while age, energy intake and body mass index (BMI) (β = -.24, 95% CI = -0.37 to -0.10) were negatively associated with TRP. Age, BMI and total homocysteine were associated with higher KYN, whereas non-western geographical origin was associated with lower KYN (β = -.09, 95% CI = -0.16 to -0.03). Protein intake and total homocysteine (β = .07, 95% CI = 0.03-0.11) had a positive association with 5-HTP, while a negative association was found for energy intake. A non-western geographical origin and drug use were associated with higher 5-HT, and BMI with lower 5-HT (β = -6.32, 95% CI = -10.26 to -2.38). Age was positively associated with 5-HIAA (β = .92, 95% CI = 0.29-1.56), and BMI negatively.
UNASSIGNED: Periconceptional non-medical maternal determinants, including age, geographical origin, drug use, energy and protein intake, BMI and total homocysteine, influence KP and SP metabolite concentrations.