■支气管扩张患者的检查要求通常通过支气管镜检查进行微生物鉴定。然而,是否进行支气管或肺活检,是未知的,特别是对NTM肺部疾病的诊断。我们旨在评估在这种情况下不同支气管镜程序的当前实践和产量。
■对接受支气管镜检查进行微生物采样的支气管扩张成年队列的数据进行了回顾,包括人口统计,病因学,进行的不同支气管镜程序的成像和结果。
■分析了127名受试者(平均年龄61岁,56%为女性)。44%的BAL培养阳性。常见病原体为流感嗜血杆菌(20%),铜绿假单胞菌(8%)和金黄色葡萄球菌(7%)。NTM和结核病分别占6%和1.5%。BAL细胞学检查是在125个程序中发送的,51例患者(40%)进行了EBB,38例患者(30%)进行了TBLB。在微生物学诊断方面,BAL细胞学和EBB和TBB(包括组织培养)均未优于BAL。包括分枝杆菌疾病的鉴定。
■在需要支气管镜检查以进行微生物学表征的非CF支气管扩张的成年受试者中,经常进行BAL细胞学检查和肺组织活检,但与BAL培养相比(包括分枝杆菌肺病)的额外益处微乎其微。而且很可能是徒劳的.
UNASSIGNED: Workup of bronchiectasis patients mandates microbiological characterization often being sought via Bronchoscopy. However, whether to perform bronchial or lung biopsies, is unknown, especially for the diagnosis of NTM pulmonary disease. We aimed to assess the current practice and yield of the different bronchoscopic procedures in this setting.
UNASSIGNED: Data from an adult cohort with bronchiectasis referred for bronchoscopy for microbiologic sampling was reviewed, including demographics, etiology, imaging and results of the different bronchoscopic procedures performed.
UNASSIGNED: 127 subjects were analyzed (mean age 61, 56% female). BAL culture was positive in 44%. Frequent pathogens were Hemophilus Influenza (20%), pseudomonas aeruginosa (8%) and Staphylococcus aureus (7%). NTM and tuberculosis were found in 6% and 1.5% respectively. BAL cytology was sent in 125 procedures, EBB was performed in 51 patients (40%) and TBLB in 38 patients (30%). BAL cytology and both EBB and TBB (including tissue cultures) had no benefit over BAL with respect to microbiological diagnosis, including identification of mycobacterial disease.
UNASSIGNED: In adult subjects with Non-CF bronchiectasis requiring bronchoscopy for microbiological characterization, BAL cytology and lung tissue biopsies were frequently performed but were of minimal additional benefit over BAL culture (including for mycobacterial pulmonary disease), and are most likely futile.