目的:我们的目的是比较研究nidogen-1(NID1)和legumain(LGMN)在子宫内膜癌患者中的表达,子宫内膜上皮内瘤变,和增生性子宫内膜。
方法:横截面,单中心研究由我们机构的妇产科和病理科进行.描述性数据之间的关系,临床病理信息,并检测NID1和LGMN的免疫组化表达。
结果:按FIGO分类的子宫内膜癌(n=124)的组织学分级包括1(41,21.1%),2(48,24.7%),和3(35,18.0%)。深层和浅层NID1表达的中位数和范围分别为50.00(0-285)和5.00(0-100),分别。Legumain表达强度为阴性(30,24.2%),轻度(16,12.9%),中等(27%,21.8%),或强劲(51,41.1%)。中位无病生存期和总生存期分别为75.00(范围:1至170)个月和77.00(范围:1至170)个月,分别。NID1和LGMN表达更强烈的患者表现出更高的组织学分级。这些患者更有可能有一个阳性的腹膜细胞学,肿瘤较大,子宫肌层或淋巴血管浸润的趋势更高,卵巢受累,子宫颈,网膜,以及淋巴结转移,和复发。
结论:我们的数据表明,NID1和LGMN的表达可能在子宫内膜病变中具有重要的诊断意义。应进一步研究了解NID1和LGMN在子宫内膜肿瘤发病机制中的意义。
OBJECTIVE: Our purpose was to comparatively investigate the expressions of nidogen-1 (NID1) and legumain (LGMN) in patients with endometrial cancer, endometrial intraepithelial neoplasia, and proliferative endometrium.
METHODS: A cross-sectional, single-center study was performed by the obstetrics and gynecology and pathology departments of our institution. The relationships between descriptive data, clinicopathologic information, and immunohistochemical expressions of NID1 and LGMN were investigated.
RESULTS: The histological grades of endometrial cancers (n = 124) as classified by FIGO included 1 (41, 21.1%), 2 (48, 24.7%), and 3 (35, 18.0%). The medians and ranges of deep and superficial NID1 expressions were 50.00 (0-285) and 5.00 (0-100), respectively. The intensity of legumain expression was noted as negative (30, 24.2%), mild (16, 12.9%), moderate (27, 21.8%), or strong (51, 41.1%). Median disease-free survival and overall survival were 75.00 (range: 1 to 170) months and 77.00 (range: 1 to 170) months, respectively. Patients with more intense expression of NID1 and LGMN displayed a higher histological grade. These patients were more likely to have a positive peritoneal cytology, larger tumor size, higher tendency for myometrial or lymphovascular invasion, involvement of ovaries, cervix, omentum, as well as lymph node metastasis, and recurrence.
CONCLUSIONS: Our data indicated that the expressions of NID1 and LGMN may have important diagnostic implications in endometrial pathologies. Further studies should be performed to understand the significance of NID1 and LGMN in the pathogenesis of endometrial tumors.