这项研究的目的是使用氯化镍盐和称为DPMN的席夫碱配体产生稳定的镍纳米颗粒。合成过程涉及两步相转移程序。使用诸如UV-可见光和FT-IR的光谱技术来确认配体稳定的镍纳米颗粒(DPMN-NiNP)的形成。要分析大小,表面形态,和DPMN-NiNPs的质量,利用SEM和TEM技术。进行了体外研究,以研究合成化合物对三种不同癌细胞系和一种正常细胞系的潜在抗癌活性。并将结果与顺铂的结果进行了比较。研究人员还进行了测试,以确定DPMN-NiNPs结合CT-DNA的能力,使用各种技术,如电子吸收,荧光,测粘度,和循环伏安法。结果表明,合成的DPMN-NiNPs具有良好的DNA结合能力,通过使用热和声化学方法对DNA进行变性进一步验证。研究人员还研究了DPMN-NiNPs的抗菌和抗氧化活性,表现出比单独的DPMN更好的生物活性。此外,发现合成的纳米化合物选择性地损伤癌细胞系,而不伤害正常细胞系。最后,研究人员通过使用紫外可见光谱法测试DPMN-NiNPs分解甲基红染料的能力,研究了DPMN-NiNPs作为染料降解催化剂的潜力。由RamaswamyH.Sarma沟通。
合成具有头基团和尾基团的生物活性有机席夫碱配体头基团相互作用并稳定镍纳米颗粒Ni纳米颗粒的平均尺寸为45nm固体并制备稳定的镍纳米颗粒。镍纳米颗粒具有良好的生物性能和催化性能。
The objective of this research was to create stable nickel nanoparticles using nickel chloride salt and a Schiff base ligand called DPMN. The synthesis process involved a two-step phase transfer procedure. Spectroscopic techniques such as UV-Visible and FT-IR were used to confirm the formation of ligand-stabilized nickel nanoparticles (DPMN-NiNPs). To analyze the size, surface morphology, and quality of DPMN-NiNPs, SEM and TEM techniques were utilized. In vitro studies were performed to investigate the potential anticancer activity of the synthesized compounds against three different cancer cell lines and one normal cell line, and the results were compared to those of cis-platin. The researchers also conducted tests to determine the ability of DPMN-NiNPs to bind to CT-DNA using various techniques such as electronic absorption, fluorescence, viscometric, and cyclic voltammetric. The results showed that the synthesized DPMN-NiNPs exhibited good DNA binding ability, which was further validated by denaturation of DNA using thermal and sonochemical methods. The researchers also investigated the antimicrobial and antioxidant activities of DPMN-NiNPs, which demonstrated better biological activities than DPMN alone. Furthermore, the synthesized nano compounds were found to selectively damage cancer cell lines without harming normal cell lines. Finally, the researchers examined the potential of DPMN-NiNPs as a catalyst in dye degradation by testing its ability to decompose methyl red dye using UV-Visible spectroscopy.Communicated by Ramaswamy H. Sarma.
Bioactive organic Schiff-base ligand having head group and tail group was synthesizedHead group interacted and stabilized the nickel nanoparticlesAverage size of the Ni nanoparticles is 45 nmSolid and stable nickel nanoparticles were prepared.Nickel nanoparticles have good biological properties as well as catalytical properties.