■核应用越来越多地用于各个领域,有必要进行研究以防止辐射危害及其影响。在这项研究中,合成了5种不同化学结构的吡唑并[3,4-b]吡啶衍生物。确定了这些样品的伽马和中子辐射防护能力,并证明了它们作为辐射防护药物成分的潜在用途。
■理论和实验计算了γ辐射吸收参数。使用蒙特卡罗模拟Geant4代码计算了快中子(4.5MeV能量辐射)的重要衰减参数。此外,测量每个样品的实验剂量率,并与石蜡和高密度聚乙烯进行比较,有机物质.此外,艾姆斯/沙门氏菌试验系统旨在检测吡唑并吡啶衍生物的遗传毒性特征。
■所有结果表明,每个样品都具有伽马和中子辐射衰减能力。确定样品PPC4(C20H14BrN5)在所有样品中表现出最高的伽马辐射衰减能力,而样品PPC2(C22H20N6)显示出优异的中子停止能力。使用Ames/沙门氏菌试验检查了吡唑并[3,4-b]吡啶衍生物的遗传毒性,结果,确定这些物质在高达5mM的测试剂量下不表现出遗传毒性作用。
■所有获得的结果表明,所有PPC(吡唑并[3,4-b]吡啶衍生物)样品均不具有毒性作用,它们可以用作活性物质,用于开发具有抗伽马和中子辐射的保护性能的药物或乳膏。
UNASSIGNED: Nuclear applications are being increasingly used in various fields, necessitating studies to protect from radiation hazards and their effects. In this study, five different chemical structures of pyrazolo [3,4-b] pyridine derivatives were synthesized. The gamma and neutron radiation protective abilities of these samples were determined and demonstrated their potential use as ingredients in radioprotective drugs.
UNASSIGNED: Gamma radiation absorption parameters were calculated both theoretical and experimental. Important attenuation parameters for fast
neutrons (4.5 MeV energy radiation) were figured out using the Monte Carlo simulation Geant4 code. Additionally, experimental dose rates were measured for each sample and compared to those of Paraffin and high-density polyethylene, an organic substance. Besides, Ames/Salmonella test system was aimed to detecting genotoxicity features of pyrazolo pyridine derivatives.
UNASSIGNED: All results demonstrated that each sample possesses both gamma and neutron radiation attenuation capabilities. It was determined that sample PPC4 (C20H14BrN5) exhibited the highest gamma radiation attenuation capacity among all samples, while sample PPC2 (C22H20N6) displayed an excellent neutron stopping capacity. The genotoxic properties of pyrazolo[3,4-b] pyridine derivatives were examined using the Ames/Salmonella test, and as a result, it was determined that these substances did not exhibit genotoxic effects at test doses up to 5 mM.
UNASSIGNED: All obtained results indicate that all PPC (pyrazolo[3,4-b] pyridine derivatives) samples do not possess a toxic effect, and they can be utilized as an active substance for the development of a drug or cream with protective properties against both gamma and neutron radiations.