■内脏肥胖是严重COVID-19的重要危险因素。然而,中国内脏肥胖指数(CVAI)对SARS-CoV-2疫苗疗效的影响仍知之甚少.本研究旨在探讨CVAI对SARS-CoV-2灭活疫苗中中和抗体(NAb)产生的影响及其潜在机制。从而优化疫苗接种指导。
■在这项横断面研究中,206名卫生工作者(2月8日和3月10日完成了两次SARS-CoV-2疫苗接种,分别为2021年)。收集参与者的所有基线人体测量参数,6周后取静脉血,测定外周先天性免疫细胞,炎性细胞因子,和抗SARS-CoV-2的NAb滴度。根据公式计算CVAI,并根据CVAI中位数将参与者分为两组。
■医护人员的NAb滴度中位数为12.94AU/mL,SARS-CoV-2疫苗的有效率为87.86%。CVAI功能障碍组的NAb滴度低于CVAI参考组(中位数:11.40AU/mLvs15.57AU/mL),CVAI功能障碍组的hsCRP水平(中位数:0.50mg/Lvs0.30mg/L)和外周血单核细胞计数(平均值:0.47×109/Lvs0.42×109/L)高于CVAI参照组.此外,CVAI与hsCRP呈正相关,单核细胞,淋巴细胞,B淋巴细胞,与NAb滴度呈负相关。
■CVAI可能通过诱导免疫功能障碍和慢性炎症抑制SARS-CoV-2中和抗体的表达。因此,应更加重视高CVAI人群的疫苗接种,以提高疫苗接种的有效性,这可以为COVID-19疫情防控提供更有力的支持。
UNASSIGNED: Visceral adiposity is a significant risk factor for severe COVID-19. However, the impact of the Chinese visceral adiposity index (CVAI) on the efficacy of SARS-CoV-2 vaccines remains poorly understood. This study aims to explore the impact of CVAI on the production of neutralizing antibodies (NAb) in inactivated SARS-CoV-2 vaccines and the potential mechanism, thereby optimizing vaccination guidance.
UNASSIGNED: In this cross-sectional study, 206 health workers (completed two SARS-CoV-2 vaccination on February 8th and March 10th, 2021, respectively) were recruited. All baseline anthropometric parameters of the participants were collected, and venous blood samples were obtained 6 weeks later to measure peripheral innate immune cells, inflammatory cytokines, and NAb titers against SARS-CoV-2. CVAI were calculated according to the formula and divided participants into two groups depending on CVAI median.
UNASSIGNED: The median NAb titer among healthcare workers was 12.94 AU/mL, with an efficacy of 87.86% for the SARS-CoV-2 vaccine. NAb titers were lower in the CVAI dysfunction group than in the CVAI reference group (median: 11.40 AU/mL vs 15.57 AU/mL), the hsCRP levels (median: 0.50 mg/L vs 0.30 mg/L) and peripheral monocyte count (mean: 0.47 × 109/L vs 0.42 × 109/L) in the CVAI dysfunction group were higher than in the CVAI reference group. Additionally, CVAI showed positive correlations with hsCRP, monocytes, lymphocytes, and B-lymphocytes, and a negative correlation with NAb titers.
UNASSIGNED: CVAI may inhibit SARS-CoV-2 neutralizing antibody expression through inducing immune dysfunction and chronic inflammation. Thus, more attention should be paid to the vaccination for high CVAI population to improve the effectiveness of vaccination, which could provide more robust support for COVID-19 epidemic prevention and control.