未经证实:接受癌症治疗的患者以及癌症幸存者通常描述行为改变。事实上,神经精神不良事件(NPAEs)已被广泛描述与旧的免疫疗法,尤其是干扰素α.然而,研究免疫检查点抑制剂(ICIs)的NPAEs的数据很少.因此,本研究的目的是根据NPAEs评估ICI的安全性.
未经批准:这是一个潜在的,介入,自我对照研究。参与者接受ICIs作为独特的治疗,在2019年2月至12月之间,在治疗方案开始时进行了评估,在1个月,最后在3个月。在三次评估中,评估了疾病和患者的特征,以及使用简明精神病学评定量表(BPRS)问卷的NPAEs,使用赫斯希望指数,癌症负担造成的心理压力,和使用东部肿瘤协作组(ECOG)评分的表现状态(PS)。
未经批准:纳入了44例患者,其中24名患者完成了3次评估访视。在整个研究期间未发现BPRS总分的变化。然而,BPRS的两个子得分,“运动迟缓”(P=0.008)和“紧张”或“紧张”(P=0.002),从治疗的第一个月开始增加。此外,年龄(r=0.426,P=0.038)和基线PS(P=0.027)是此类表现的主要危险因素。
UNASSIGNED:这项研究表明,ICI可能是治疗第1个月开始的运动迟缓和紧张增加的原因,较高的ECOG评分和年龄是主要危险因素。
UNASSIGNED: Patients undergoing cancer treatment as well as cancer survivors commonly describe behavioral alterations. As a matter of fact, neuropsychiatric adverse events (NPAEs) have been extensively described with older immunotherapies, especially with interferon alfa. However, there are little data investigating the NPAEs of immune checkpoint inhibitors (ICIs). Therefore, the aim of this study is to evaluate the safety profile of ICI in terms of NPAEs.
UNASSIGNED: This is a prospective, interventional, self-controlled study. Participants receiving ICIs as unique therapy, between February and December 2019, were evaluated at the beginning of their treatment protocol, at 1 month and finally at 3 months. During the three evaluations, disease and patients\' characteristics were assessed, as well as NPAEs using the Brief Psychiatric Rating Scale (BPRS) questionnaire, the psychological stress due to cancer\'s burden using the Herth hope index, and the performance status (PS) using the Eastern Cooperative Oncology Group (ECOG) score.
UNASSIGNED: Forty-four patients were enrolled, of whom 24 patients completed their three evaluation visits. No changes in BPRS total score were found throughout the study period. However, two subscores of the BPRS, \"motor retardation\" (P = 0.008) and \"tension\" or \"
nervousness\" (P = 0.002), increased starting the 1st month of treatment. Moreover, age (r = 0.426, P = 0.038) and the baseline PS (P = 0.027) were the main risk factors of such manifestations.
UNASSIGNED: This study suggests that ICI could be responsible for motor retardation and increased tension starting the 1st month of treatment, with higher ECOG score and older age being the main risk factors.