Oleandrin,从夹竹桃叶片中分离出的强心苷,对心脏有已知的影响。来自最近研究的证据强调了其抗癌特性的潜力。因此,我们旨在研究夹竹桃苷对癌细胞增殖的影响,体外和体内的活力和凋亡。截至2022年1月,我们在六个电子数据库中进行了系统搜索。我们提取了夹竹桃苷对细胞增殖影响的信息,细胞活力,体外研究中的凋亡和/或细胞周期停滞,以及在动物实验模型中对肿瘤大小和体积的影响。我们检索了775项科学研究。14项研究符合纳入标准。他们研究了夹竹桃苷对乳房的影响,肺,胰腺,结肠,前列腺,结直肠,口服,卵巢,神经胶质瘤,黑色素瘤,胶质母细胞瘤,骨肉瘤,和组织细胞淋巴瘤。总的来说,体外研究表明,夹竹桃苷能够抑制细胞增殖,降低细胞活力,并诱导细胞凋亡和/或细胞周期停滞。此外,夹竹桃苷在动物研究中对减少平均肿瘤大小和体积有作用。Oleandrin,作为一种细胞毒性剂,在不同类型的癌症中表现出抗肿瘤作用,然而,重要的临床局限性仍然令人担忧。这些结果鼓励未来的研究,以验证夹竹桃苷在抗肿瘤治疗方案人类和兽医学中的适用性,抗转移特性的研究,以及患者生存率的潜在增加和肿瘤标志物的减少。
Oleandrin, a cardiac glycoside isolated from the leaves of Nerium oleander, has known effects on the heart. Evidence from recent studies have highlighted its potential for anticancer properties. Therefore, we aimed to investigate the effects of oleandrin on cancer cell proliferation, viability and apoptosis in vitro and in vivo. We performed a systematic search in six electronic databases up to Jan 2022. We extracted information about the effects of oleandrin on cell proliferation, cell viability, apoptosis and/or cell cycle arrest in in vitro studies, and the effects on tumor size and volume in animal experimental models. We have retrieved 775 scientific studies. 14 studies met the inclusion criteria. They investigated the effects of oleandrin on breast, lung, pancreatic, colon, prostate, colorectal, oral, ovarian, glioma, melanoma, glioblastoma, osteosarcoma, and histiocytic lymphoma cancers. Overall, in vitro studies demonstrated that oleandrin was able to inhibit cell proliferation, decrease cell viability, and induce apoptosis and/or cell cycle arrest. In addition, oleandrin had an effect on reducing mean tumor size and volume in animal studies. Oleandrin, as a cytotoxic agent, demonstrated antitumor effects in different types of cancers, however important clinical limitations remain a concern. These results encourage future studies to verify the applicability of oleandrin in antineoplastic therapeutic protocols human and veterinary medicine, the investigation of antimetastatic properties, as well as the potential increase in patient survival and the decrease of tumor markers.