患有糖尿病的男性经常经历生精功能障碍,这是糖尿病损害其繁殖能力的最重要迹象。各种剂量的夹竹桃叶水醇提取物对垂体-性腺轴的影响,精子活力和数量,抗氧化系统,睾丸组织结构的改变,和精子发生在健康和糖尿病大鼠已经在目前的研究中进行了检查。将80只链脲佐菌素诱导的糖尿病健康雄性大鼠分为8组:(1)对照组,(2)莲花(50mg/kg),(3)莲花(100mg/kg),(4)莲花(200mg/kg),(5)DM(6)DM+夹竹桃(50mg/kg),(7)DM+夹竹桃(100mg/kg)和(8)DM+夹竹桃(200mg/kg),连续口服给药48天。在研究之后,分析睾丸组织的抗氧化能力以及精子参数,约翰森的评分和形态测量评估,组织学,进行了生化和体视学研究.结果显示,Nerium50和100mg/kg可显著增强睾丸形态,精子参数,和生殖器官在不同程度的糖尿病大鼠。在50mg/kg给药后,睾丸组织中的谷胱甘肽过氧化物酶(GPX)和过氧化氢酶(CAT)水平升高,而丙二醛(MDA)水平显着降低。Nerium可能通过在较低剂量下增强抗氧化酶的活性来帮助保护雄性大鼠免受糖尿病诱导的生精功能障碍。
Men with diabetes frequently experience spermatogenic dysfunction, which is the most significant sign that diabetes has harmed their ability to reproduce. The effect of various doses of the hydro-alcoholic extract of
Nerium oleander leaves on the pituitary-gonadal axis, sperm motility and number, antioxidant system, changes in testicular tissue structure, and spermatogenesis in healthy and diabetic rats has been examined in the current study. Eighty male rats that had been streptozotocin-induced diabetic and healthy were divided into eight groups: (1) control, (2)
Nerium (50 mg/kg), (3)
Nerium (100 mg/kg), (4)
Nerium (200 mg/kg), (5) DM (6) DM+
Nerium (50 mg/kg), (7) DM+
Nerium (100 mg/kg) and (8) DM+
Nerium (200 mg/kg) and were administered orally for 48 days consecutive. Following the studies, analysis of the testicular tissues\' antioxidant capacity as well as sperm parameters, Johnsen\'s scoring and morphometric evaluation, histology, biochemical and stereology studies were performed.The outcomes showed that Nerium 50 and 100 mg/kg considerably enhanced the testicular morphology, sperm parameters, and reproductive organs to varying degrees in diabetic rats. After Nerium 50 mg/kg administration, glutathione peroxidase (GPX) and catalase (CAT) levels in the testicular tissue were increased whereas malondialdehyde (MDA) levels were markedly decreased.
Nerium may help protect against diabetic-induced spermatogenic dysfunction in male rats by enhancing the activities of antioxidant enzymes in lower dosages.