■克隆浆细胞的聚集导致浆细胞肿瘤,严重程度和临床结果各不相同。目前的研究集中在流行病学,临床,免疫学,和浆细胞肿瘤的细胞遗传学特征。
■在这项为期五年的回顾性横断面研究中,人口统计信息,如年龄和性别,钙升高,肾功能不全,贫血,骨损伤(CRAB)的特点,以及实验室数据,包括骨髓和外周血膜结果,免疫组织化学,流式细胞术,细胞遗传学研究结果在设拉子医科大学收集,设拉子,伊朗。使用SPSSStatistics软件(20.0版)对收集的数据进行分析。描述性统计数据被报告为数字,百分比,和平均值±SD。
■417例新诊断的浆细胞肿瘤患者通过骨髓或其他组织活检检查证实。279例患者为男性(66.9%)。最普遍的年龄组是60-64岁(18.46%)。浆细胞骨髓瘤(PCM)影响355(85.13%)患者,而意义不明的单克隆丙种球蛋白病(MGUS)影响了6例(1.43%)患者。在56例(13.42%)患者中发现了孤立性浆细胞瘤。在诊断的时候,355例PCM患者中有119例(33.52%)无症状,而236例(66.47%)患者至少有一种CRAB症状,55(15.49%)有两个或两个以上,和14(3.94%)有三个或以上。淀粉样变性7例(1.97%)。51.28%(40/78)的患者发现细胞遗传学异常。21个个体(52.5%)是多体三体的超二倍体,而19人(47.50%)没有。
■诊断时,伊朗PCM患者可能患有更晚期的疾病。PCM在年轻人中更为普遍,超二倍体是本次研究中最常见的细胞遗传学发现。
UNASSIGNED: The aggregation of clonal plasma cells causes plasma cell neoplasms, which vary in severity and clinical outcomes. The present research focused on the epidemiological, clinical, immunologic, and cytogenetic characteristics of plasma cell neoplasms.
UNASSIGNED: In this five-year retrospective cross-sectional study, demographic information such as age and sex, calcium elevation, renal insufficiency, anemia, and bone lesion (CRAB) characteristics, as well as laboratory data including bone marrow and peripheral blood film results, immunohistochemistry, flow cytometry, and cytogenetic study outcomes were collected at Shiraz University of Medical Sciences, Shiraz, Iran. The collected data were analyzed using SPSS Statistics software (version 20.0). Descriptive statistics were reported as numbers, percentages, and mean±SD.
UNASSIGNED: 417 newly diagnosed plasma cell neoplasm patients were confirmed by bone marrow or other tissue biopsy tests. 279 patients were men (66.9%). The most prevalent age group was 60-64 years old (18.46%). Plasma cell myeloma (PCM) affected 355 (85.13%) patients, while monoclonal gammopathy of undetermined significance (MGUS) affected 6 (1.43%) patients. Solitary plasmacytoma was seen in 56 (13.42%) patients. At the time of diagnosis, 119 (33.52%) of 355 PCM patients were asymptomatic, whereas 236 (66.47%) patients had at least one CRAB symptom, 55 (15.49%) had two or more, and 14 (3.94%) had three or more. There were 7 (1.97%) cases of amyloidosis. Cytogenetic abnormalities were found in 51.28% (40/78) of the patients. Twenty-one individuals (52.5%) were hyperdiploid with multiple trisomy, while 19 (47.50%) were not.
UNASSIGNED: When diagnosed, Iranian PCM patients might have more advanced disease. PCM was more prevalent in young adults, and hyperdiploid was the most common cytogenetic finding in this investigation.