We report a case of Volkmann\'s-like syndrome occurred after an extravasation of 300 mg of cordarone administrated for a cardiac arrest.The day following the extravasation, an extensive necrosis of the skin and soft tissues occurred. The patient progressively developed a retraction of the muscles of her forearm. To the best of our knowledge this is first the reported case of an acute necrosis of the soft tissue inducing a Volkmann\'s-like retraction of the upper limb subsequent to a cordarone extravasation. The imaging findings are provided along with a review of the literature.