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  • 文章类型: Journal Article
    背景:椎弓根螺钉侵犯小关节可能导致相邻节段疾病和术后疼痛。先前的研究已经报道了使用各种椎弓根螺钉插入技术的头骨小关节侵犯的发生率。然而,尚未确定在机器人引导下侵犯小关节的发生率。
    目的:研究并比较机器人引导和计算机断层扫描(CT)导航引导下椎弓根螺钉侵犯头端小关节的发生率。
    方法:回顾性匹配队列患者样本:所有直到2023年在主要脊柱中心接受机器人辅助腰椎融合术的患者均进行回顾性鉴定,并根据年龄与接受CT导航引导的患者进行1:3匹配,性别,头端椎体水平,和构造的长度。纳入标准包括年龄大于18岁,双侧椎弓根螺钉固定,以及术后任何时候腰椎或腹部/骨盆的CT扫描。
    方法:头颅关节侵犯方法:使用描述性统计来比较队列:频率,分类变量的卡方分析,和连续变量的t检验。
    结果:204例患者共植入408枚头端椎弓根螺钉(机器人:102;导航:306)。总的来说,在机器人队列中观察到13例(12.3%)头端小关节侵犯,在导航队列中观察到75例(24.5%)(p=0.01)。具体来说,在L2观察到较少的机器人违规(3.5%对32.1%,p=0.003)和L3水平(3.9%与18.1%,p=0.08)与导航相比。在L4和L5没有观察到差异。机器人方法显著减少了双边违规行为(5.3%与14.4%,p=0.03)。最后,在开放式进近期间观察到更多的关节侵犯(机器人:18.8%,导航:27.3%)比经皮入路(机器人:11.6%,导航:7.1%),两组(p<0.001)。L4小平面侵犯率在机器人队列中为18.8%,在导航队列中为27.3%。在机器人队列中,L5小平面违规率为31.3%,在导航队列中为29.2%。
    结论:与L2和L3水平的导航引导相比,在腰椎椎弓根螺钉中使用机器人辅助显着降低了头端小关节侵犯的发生率,但在L4和L5时则没有,L5螺钉处的小平面侵犯接近近三分之一的患者。在邻近节段变性和疾病中,颅骨小平面的侵犯可以发挥重要作用。技术因素和轨迹问题可能会发挥作用,解决这些组件应尽量减少意外的方面违规和近端增加。
    BACKGROUND: Facet joint violation by pedicle screws may lead to adjacent-segment disease and postoperative pain. Previous studies have reported the incidence of rostral facet joint violation using various pedicle screw insertion techniques. However, the incidence of facet joint violations with robotic guidance has not been determined.
    OBJECTIVE: To investigate and compare the incidence of rostral facet joint violation by pedicle screws under robotic guidance and computerized tomography (CT) navigation guidance.
    METHODS: Retrospective Matched Cohort PATIENT SAMPLE: All patients who underwent robotic-assisted lumbar fusion at a major spine center up until 2023 were retrospectively identified and matched 1:3 to patients undergoing CT navigation guidance based by on age, sex, rostral vertebral level, and length of construct. Inclusion criteria consisted of age greater than 18 years, bilateral pedicle screw fixation, and presence of a postoperative CT scan of the lumbar spine or abdomen/pelvis at any point in the post-operative period.
    METHODS: Rostral facet joint violations METHODS: Descriptive statistics were used to compare cohorts: frequencies, chi-squared analysis for categorical variables, and t-test for continuous variables.
    RESULTS: A total of 408 rostral pedicle screws were implanted in 204 patients (Robot: 102; Navigation: 306). Overall, 13 (12.3%) rostral facet joint violations were observed in the robot cohort and 75 (24.5%) in the navigation cohort (p=0.01). Specifically, fewer robotic violations were observed at the L2 (3.5% vs 32.1%, p=0.003) and L3 levels (3.9% vs. 18.1%, p=0.08) compared to navigation. No difference was observed at L4 and L5. Bilateral violations are significantly reduced with robotic approaches (5.3% vs. 14.4%, p=0.03). Lastly, more facet joint violations were observed during open approaches (robot: 18.8%, navigation: 27.3%) than percutaneous approaches (robot: 11.6%, navigation: 7.1%) in both groups (p<0.001). The rate of L4 facet violations was 18.8% in the robotic cohort and 27.3% in the navigation cohort. The rate of L5 facet violations was 31.3% in the robotic cohort and 29.2% in the navigation cohort.
    CONCLUSIONS: Use of robotic assistance in lumbar pedicle screws significantly reduced the rate of rostral facet joint violations compared to navigation guidance at L2 and L3 levels, but not at L4 and L5, with facet violations approaching nearly one-third of the patients at L5 screws. Rostral facet violations can play a significant role in adjacent segment degeneration and disease. Technical factors and trajectory issues likely play a role and addressing these components should minimize unintended facet violation and proximal adding on.
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  • 文章类型: Journal Article
    航海能力随着年龄的增长而下降,但是这种认知能力下降的认知基础仍然被部分理解。导航由地标和自运动线索引导,我们在估计我们的位置时解决的问题。这些空间信息的来源通常与噪声和不确定性有关,因此在导航过程中构成了挑战。为了克服这一挑战,人类和其他物种根据其可靠性依赖于导航线索:可靠线索具有很高的权重,因此强烈影响我们的空间行为,与不太可靠的相比。我们假设老年人不能有效地衡量空间线索,因此,导航线索的可靠性水平可能不会调节它们的空间行为,和年轻的成年人一样。为了测试这个,年轻人和老年人执行虚拟导航任务,受地标和自运动线索可靠性的影响。研究结果表明,虽然空间线索的可靠性提高了两个年龄组的导航性能,老年人对界标可靠性变化的敏感性降低.研究结果表明,一种认知机制可能导致老年人的导航能力受损。
    Navigational abilities decline with age, but the cognitive underpinnings of this cognitive decline remain partially understood. Navigation is guided by landmarks and self-motion cues, that we address when estimating our location. These sources of spatial information are often associated with noise and uncertainty, thus posing a challenge during navigation. To overcome this challenge, humans and other species rely on navigational cues according to their reliability: reliable cues are highly weighted and therefore strongly influence our spatial behavior, compared to less reliable ones. We hypothesize that older adults do not efficiently weigh spatial cues, and accordingly, the reliability levels of navigational cues may not modulate their spatial behavior, as with younger adults. To test this, younger and older adults performed a virtual navigational task, subject to modified reliability of landmarks and self-motion cues. The findings revealed that while increased reliability of spatial cues improved navigational performance across both age groups, older adults exhibited diminished sensitivity to changes in landmark reliability. The findings demonstrate a cognitive mechanism that could lead to impaired navigation abilities in older adults.
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  • 文章类型: Journal Article
    在自然环境中,感官系统在电机输出的闭环中运行,由此,行动塑造了随后的感官体验。这方面的一个主要例子是所需的感觉运动处理,以对准一个人的行进方向,或航向,以一个人的目标,我们称之为转向的行为。在转向中,电机输出工作,以消除航向和目标之间的误差,修改过程中的后续错误。行为的闭环性质使得确定确定性和非确定性过程如何对行为做出贡献具有挑战性。我们通过应用非参数来克服这一点,在两个实验环境中,对通过虚拟环境操纵的猴子的行为数据进行基于线性核的分析。在给定的背景下,结果与以前的工作一致,将变换描述为二阶线性系统。经典的,例如,这样的二阶模型的参数与肢体的物理特性(诸如通常被假定为近似恒定的粘度和刚度)相关联。相比之下,我们发现,在这些和其他参数中,各个任务的拟合内核差异很大,提示神经和生物力学过程中上下文相关的变化。我们还将残差拟合到一个简单的噪声模型中,发现噪声的形式在环境和动物中都高度保守。引人注目的是,装配的噪音也与以前在人类转向任务中发现的噪音非常匹配。总之,这项工作提出了一种基于内核的分析,该分析表征了闭环感觉运动任务的确定性和非确定性组件的上下文依赖性。
    我们使用非参数系统识别技术来评估确定性和非确定性贡献对闭环行为的上下文依赖性。经典方法假定感觉输入和运动输出之间的固定转换。这里,我们揭示了行为背景下测量的感觉运动转换的强烈变化。相比之下,转换中的噪声在上下文中表现出一致的形式,主题,和物种。一起,这项工作演示了上下文如何影响闭环行为的系统和随机组件。
    In natural circumstances, sensory systems operate in a closed loop with motor output, whereby actions shape subsequent sensory experiences. A prime example of this is the sensorimotor processing required to align one\'s direction of travel, or heading, with one\'s goal, a behavior we refer to as steering. In steering, motor outputs work to eliminate errors between the direction of heading and the goal, modifying subsequent errors in the process. The closed-loop nature of the behavior makes it challenging to determine how deterministic and nondeterministic processes contribute to behavior. We overcome this by applying a nonparametric, linear kernel-based analysis to behavioral data of monkeys steering through a virtual environment in two experimental contexts. In a given context, the results were consistent with previous work that described the transformation as a second-order linear system. Classically, the parameters of such second-order models are associated with physical properties of the limb such as viscosity and stiffness that are commonly assumed to be approximately constant. By contrast, we found that the fit kernels differed strongly across tasks in these and other parameters, suggesting context-dependent changes in neural and biomechanical processes. We additionally fit residuals to a simple noise model and found that the form of the noise was highly conserved across both contexts and animals. Strikingly, the fitted noise also closely matched that found previously in a human steering task. Altogether, this work presents a kernel-based analysis that characterizes the context-dependence of deterministic and non-deterministic components of a closed-loop sensorimotor task.
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  • 文章类型: Journal Article
    行人在非约束环境中的行为很难预测。在可穿戴机器人技术中,这构成了挑战,由于下肢外骨骼和活动矫形器等设备需要支持不同的步行活动,包括水平行走和爬楼梯。虽然固定的运动轨迹可以很容易地支持,这些活动之间的切换很难预测。此外,预计未来几年对这些设备的需求将上升。在这项工作中,我们提出了一种用于可穿戴机器人的云软件系统,基于地理制图技术和人类活动识别(HAR)。该系统旨在通过提供事后的信息来为周围的行人提供上下文。该系统已部分实现和测试。结果表明,这是一个可行的概念,具有很大的可扩展性前景。
    The behavior of pedestrians in a non-constrained environment is difficult to predict. In wearable robotics, this poses a challenge, since devices like lower-limb exoskeletons and active orthoses need to support different walking activities, including level walking and climbing stairs. While a fixed movement trajectory can be easily supported, switches between these activities are difficult to predict. Moreover, the demand for these devices is expected to rise in the years ahead. In this work, we propose a cloud software system for use in wearable robotics, based on geographical mapping techniques and Human Activity Recognition (HAR). The system aims to give context to the surrounding pedestrians by providing hindsight information. The system was partially implemented and tested. The results indicate a viable concept with great extensibility prospects.
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  • 文章类型: Journal Article
    1985年,KWOH教授首次将机器人引入神经外科。从那以后,立体定向框架的进步,射线成像和神经导航导致了经典立体定向机器人的主导地位。使用学术数据库和搜索代理进行了全面的检索,以获取专业信息,截止日期是六月,2024.这表明许多新兴技术正在走到最前沿,包括震颤过滤,运动缩放,避障,力传感,为高效率做出了重大贡献,高精度,微创,和机器人辅助神经外科手术的确切疗效。这些技术已应用于创新的磁共振兼容神经外科机器人,比如Neuroarm和Neurobot,实时图像引导手术。尽管取得了这些进步,主要挑战被认为是空间方面的磁共振兼容性,材料,驾驶,和成像。未来的研究方向预计将集中在(1)机器人精确感知;(2)人工智能;和(3)远程手术的进步。
    In 1985, Professor KWOH first introduced robots into neurosurgery. Since then, advancements of stereotactic frames, radiographic imaging and neuronavigation have led to the dominance of classic stereotactic robots. A comprehensive retrieval was performed using academic databases and search agents to acquire professional information, with a cutoff date of June, 2024. This reveals a multitude of emerging technologies are coming to the forefront, including tremor filtering, motion scaling, obstacle avoidance, force sensing, which have made significant contributions to the high efficiency, high precision, minimally invasive, and exact efficacy of robot-assisted neurosurgery. Those technologies have been applied in innovative magnetic resonance-compatible neurosurgical robots, such as Neuroarm and Neurobot, with real-time image-guided surgery. Despite these advancements, the major challenge is considered as magnetic resonance compatibility in terms of space, materials, driving, and imaging. Future research directions are anticipated to focus on (1) robotic precise perception; (2) artificial intelligence; and (3) the advancement of telesurgery.
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  • 文章类型: Journal Article
    方法:回顾性队列研究。
    目的:本研究的目的是比较基于CT的计算机辅助导航(CAN)与传统椎弓根螺钉置入对青少年特发性脊柱侧凸(AIS)患者的疗效。
    方法:这项回顾性队列研究的数据来自国家再入院数据库,2016-2019年。接受AIS后路融合的患者,通过CAN或荧光透视引导程序,通过ICD-10代码识别。进行多因素回归以比较手术技术之间的结果。负二项回归用于评估放电情况,同时进行Gamma回归以评估住院时间(LOS)和总费用。患者人口统计学和合并症,通过Elixhauser合并症指数测量,在我们的回归分析中都被控制。
    结果:28,868名患者,2095(7.3%)接受CAN程序,包括在我们的分析中。接受CAN手术的患者手术并发症增加(赔率比(OR)2.23;P<0.001),即,输血(OR2.47;P<0.001)。排水量和距离相似,再手术和再入院率也是如此;然而,CAN组的总电荷显著增加(OR1.37;P<0.001).传统手术的平均费用为191,489.42(119,302.30)美元,而CAN队列的平均费用为268.589.86(105,636.78)美元。
    结论:CAN在AIS的后路融合术中似乎并没有减少术后并发症,并且与输血需求增加有关。考虑到CAN也看到了更高的护理总成本,这项研究质疑在这种情况下使用CAN是否合理。
    METHODS: Retrospective Cohort Study.
    OBJECTIVE: The aim of this study was to compare the efficacy of CT-based computer assisted navigation (CAN) to conventional pedicle screw placement for patients with Adolescent Idiopathic Scoliosis (AIS).
    METHODS: This retrospective cohort study drew data from the National Readmissions Database, years 2016-2019. Patients undergoing posterior fusion for AIS, either via CAN or fluoroscopic-guided procedures, were identified via ICD-10 codes. Multivariate regression was performed to compare outcomes between operative techniques. Negative binomial regression was used to asses discharge disposition, while Gamma regression was performed to assess length of stay (LOS) and total charges. Patient demographics and comorbidities, measured via the Elixhauser comorbidity index, were both controlled for in our regression analysis.
    RESULTS: 28,868 patients, 2095 (7.3%) undergoing a CAN procedure, were included in our analysis. Patients undergoing CAN procedures had increased surgical complications (Odds Ratio (OR) 2.23; P < 0.001), namely, blood transfusions (OR 2.47; P < 0.001). Discharge disposition and LOS were similar, as were reoperation and readmission rates; however, total charges were significantly greater in the CAN group (OR 1.37; P < 0.001). Mean charges were 191,489.42 (119,302.30) USD for conventional surgery vs 268 589.86 (105,636.78) USD for the CAN cohort.
    CONCLUSIONS: CAN in posterior fusion for AIS does not appear to decrease postoperative complications and is associated with an increased need for blood transfusions. Given the much higher total cost of care that was also seen with CAN, this study calls into question whether the use of CAN is justified in this setting.
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  • 文章类型: Journal Article
    归巢通常是动物行为和空间生态的关键方面。迁移被认为是一种野生动物管理策略,可以减少人与野生动物的对抗,但是如果动物试图回到它们原来的捕获位置,这种策略可能不会有效。将动物从可能发生人与野生动物互动的地点转移是一种广泛但有争议的解决冲突的干预措施。在印度,蛇通常是这种易位的主体,但是,与居民蛇相比,关于易位蛇行为的信息很少。印度蟒蛇(蟒蛇),印度次大陆最大的食肉动物之一,被IUCN列为濒临威胁。我们对Moyar河谷的14只成年印度蟒蛇的运动进行了为期两年的无线电追踪研究(2018年12月至2020年12月),在Sathyamangalam和Mudumalai老虎保护区内。14条蟒蛇中有11条从捕获地点转移了0.28-55.7公里,虽然3条蟒蛇没有易位:6条易位短距离(距离捕获<5公里;范围0.28-4.67公里),2个被转移到中等距离(距捕获位置9-11公里),和3个被转移到长距离(从捕获位置21-55.7公里)。六只蛇中的四只短距离移动,都回到了原始捕获位置的500米以内,并且所有6个返回超过60%的转移距离到初始捕获位置。在两条中等距离的蛇中,两者都回到了捕获地点的1.1公里范围内(~90%的距离)。三只长距离易位的蛇都没有成功返回其捕获地点。在释放的前2个月内,移位的蟒蛇的净移动距离比常驻蛇大。基于这些结果,长距离易位可能是一种有效的策略,以尽量减少人与蟒蛇的冲突,而短距离或中距离易位不太可能成功。然而,需要对易位蛇的长期存活以及可以防止释放后直接异常运动行为的软释放方法进行更多研究。
    Homing is often a critical aspect of an animal\'s behavioural and spatial ecology. Translocation is considered to be a wildlife management strategy that could reduce human-wildlife confrontation, but this strategy may not be effective if animals attempt to home to their original capture location. Translocation of animals from sites where possible human-wildlife interaction occurs is a widespread but controversial intervention to resolve conflicts. In India, snakes are often the subject of such translocations, but there is a paucity of information on the behaviour of translocated snakes compared to resident snakes. The Indian python (Python molurus), one of the largest carnivores in the Indian subcontinent, is classified as Near Threatened by the IUCN. We conducted a two-year radio-tracking study (December 2018 to December 2020) on the movements of 14 adult Indian pythons in the Moyar River Valley, within the Sathyamangalam and Mudumalai Tiger Reserves. Eleven of the 14 pythons were translocated 0.28-55.7 kms from their capture locations, while 3 pythons were not translocated: 6 were translocated short distances (<5 km from capture; range 0.28-4.67 kms), 2 were translocated to medium distances (9-11 kms from capture location), and 3 were translocated to long distances (21-55.7 kms from capture location). Four of the six snakes translocated short distances all returned to within 500 m of their original capture locations, and all 6 returned over 60 % of the translocated distance to the initial capture location. Of the two snakes translocated medium distances, both returned to within 1.1 km of the capture location (∼90 % of the distance home). None of the three snakes that were translocated long distances successfully returned to their capture locations. Translocated pythons exhibited greater net movement distances than resident snakes within the first 2 months of release. Based on these results, long-distance translocation may be an effective strategy to minimize human-python conflict, while short or medium distance translocation is unlikely to be successful. However, more research is needed about the long-term survival of translocated snakes as well as soft-release methodologies that could prevent aberrant movement behaviour directly following release.
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  • 文章类型: Journal Article
    这项研究探讨了使用虚拟现实技术避免运动员碰撞的视觉运动控制。39名运动员导航动态场景,追求虚拟目标,同时避免两到五名虚拟防御者。验证性因素分析验证了一个模型,该模型根据活动期间记录的头部运动捕获了扫描行为的两个特征:总量和时间模式。线性混合模型表明,这些特征显着区分成功与不成功的防守者回避(p<0.05),这表明有效的环境扫描对于避免碰撞至关重要,同时突出了视觉运动干预减少碰撞相关运动损伤的潜力。
    This study explores visuomotor control in athletes for collision avoidance using virtual reality. Thirty-nine athletes navigated dynamic scenarios, pursuing a virtual target while avoiding two to five virtual defenders. Confirmatory Factor Analysis validated a model that captured two features of scanning behavior based on head movements recorded during activity: the overall amount and temporal pattern. Linear mixed models showed that these features significantly differentiated successful from unsuccessful defender avoidance (p < .05), suggesting that efficient environmental scanning is crucial for collision avoidance while highlighting the potential of visuomotor interventions to reduce collision-related sport injuries.
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  • 文章类型: Journal Article
    使用从步行者携带的智能手机记录的惯性数据的寻路系统具有提高盲人行人的移动性独立性的巨大潜力。用于定位的行人航位推算(PDR)算法需要估计步行者的步长。先前的工作表明,通过使用简单的机器学习算法处理智能手机记录的惯性数据,可以可靠地预测步长。然而,这项先前的工作只考虑了有视力的步行者,其步态可能与使用长手杖或导盲犬的盲人步行者不同。在这项工作中,我们表明,在盲人步行者上进行测试时,根据来自有视力的步行者的数据训练的步长估计网络表现不佳,并且使用来自盲人步行者的数据进行重新训练可以显着提高步长预测的准确性。
    Wayfinding systems using inertial data recorded from a smartphone carried by the walker have great potential for increasing mobility independence of blind pedestrians. Pedestrian dead-reckoning (PDR) algorithms for localization require estimation of the step length of the walker. Prior work has shown that step length can be reliably predicted by processing the inertial data recorded by the smartphone with a simple machine learning algorithm. However, this prior work only considered sighted walkers, whose gait may be different from that of blind walkers using a long cane or a dog guide. In this work, we show that a step length estimation network trained on data from sighted walkers performs poorly when tested on blind walkers, and that retraining with data from blind walkers can dramatically increase the accuracy of step length prediction.
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  • 文章类型: Journal Article
    当导航到一个地方时,学到了什么,这个问题一直是相当多的辩论的主题。流行观点强调认知结构(例如,地图)或联想学习,它在空间导航任务中形成了测量(例如,莫里斯水任务[MWT]),以选择不能捕获单个动物精确行为的粗略措施。我们在MWT中以高时间分辨率(30Hz)分析了15只大鼠(每次60次试验)的导航路径,并利用动态时间扭曲来量化动物内部和动物之间路径的相似性。道路基本上是直接的,然而次优,并包括在训练早期建立的每只动物特有的速度和轨迹的变化。从试验到试验,个体大鼠从相同的释放点执行相似的路径,这与其他大鼠执行的路径以及同一大鼠从其他释放点执行的路径不同。这些观察表明,对于MWT中的每个释放点,大鼠学习从试验到试验执行相似的路径序列。偶尔自发偏离既定的,独特的行为顺序,导致导航精度的严重中断。我们讨论了序列导航行为对理解行为与空间神经信号之间关系的潜在影响,例如位置细胞,网格单元格,和头部方向细胞。
    在线版本包含补充材料,可在10.1007/s40614-024-00402-8获得。
    The question of What is learned when navigating to a place is reinforced has been the subject of considerable debate. Prevailing views emphasize cognitive structures (e.g., maps) or associative learning, which has shaped measurement in spatial navigation tasks (e.g., the Morris water task [MWT]) toward selection of coarse measures that do not capture precise behaviors of individual animals. We analyzed the navigation paths of 15 rats (60 trials each) in the MWT at high temporal resolution (30Hz) and utilized dynamic time warping to quantify the similarity of paths within and between animals. Paths were largely direct, yet suboptimal, and included changes in speed and trajectory that were established early in training and unique to each animal. Individual rats executed similar paths from the same release point from trial to trial, which were distinct from paths executed by other rats as well as paths performed by the same rat from other release points. These observations suggest that rats learn to execute similar path sequences from trial to trial for each release point in the MWT. Occasional spontaneous deviations from the established, unique behavioral sequence, resulted in profound disruption in navigation accuracy. We discuss the potential implications of sequence navigation behaviors for understanding relations between behavior and spatial neural signals such as place cells, grid cells, and head direction cells.
    UNASSIGNED: The online version contains supplementary material available at 10.1007/s40614-024-00402-8.
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