■白喉-破伤风-无细胞百日咳,脊髓灰质炎,和B型流感嗜血杆菌(DTaP-IPV/Hib)组合疫苗于2017年6月19日作为韩国国家免疫计划(NIP)的一部分引入.组合疫苗可以通过简化疫苗接种时间表来提高疫苗接种率。
■解释在NIP中引入DTaP-IPV/Hib如何改变了婴儿的疫苗接种实践。
■使用全国疫苗登记处,完成主要DTaP系列的全部推荐剂量的婴儿比例,IPV,在2013年至2019年出生的人群中,估计12个月内的Hib(D-I-H)。其中,我们计算了2013-2016年和2017-2019年出生队列中3种剂量接受相同DTaP组分的比例.在整个初级疫苗接种方案中接受相同DTaP组分的那些人通过DTaP组分被分为3组,以比较疫苗接种的平均医疗就诊频率。
■在2013年至2019年之间,共有2,703,822名婴儿出生,其中96.7%在12个月内完成了主要D-I-H系列的全剂量。对于2013-2016年出生队列,最多收到DTaP-IPV-only(75.4%),而大多数2017-2019出生队列接受DTaP-IPV/Hib-only(81.0%)来完成主要D-I-H系列的3个剂量。接种疫苗的平均就诊频率在每个出生队列中按DTaP组分分类的3个组之间显示出显著差异(p<0.001)。
■在引入DTaP-IPV/Hib之后,大多数婴儿使用联合疫苗完成了主要的D-I-H系列接种,接种疫苗的平均就诊次数显著减少.我们的研究结果为考虑将联合疫苗引入其NIP的国家提供了重要的见解。
UNASSIGNED: Diphtheria-tetanus-acellular pertussis, polio, and Haemophilus influenza type B (DTaP-IPV/Hib) combination vaccine was introduced as a part of the Korea National Immunization Program (NIP) on June 19, 2017. Combination vaccines can improve vaccination rates by simplifying the vaccination schedule.
UNASSIGNED: To explain how the introduction of DTaP-IPV/Hib in the NIP has changed vaccination practices for infants.
UNASSIGNED: Using a nationwide vaccine registry, the proportion of infants who completed the full recommended doses of the primary series of DTaP, IPV, and Hib (D-I-H) within 12 months of age was estimated among those born between 2013 and 2019. Among those, the proportions of those who received the same DTaP components for all 3 doses during the primary series were calculated for the 2013-2016 and the 2017-2019 birth cohorts. Those who received the same component of DTaP throughout the entire primary vaccination schedule were categorized into 3 groups by DTaP components to compare the average frequency of medical visits for vaccination.
UNASSIGNED: A total of 2,703,822 infants were born between 2013 and 2019, of which 96.7% completed full doses of the primary D-I-H series within 12 months of age. For the 2013-2016 birth cohorts, most received DTaP-IPV-only (75.4%), while most of the 2017-2019 birth cohorts received DTaP-IPV/Hib-only (81.0%) to complete the 3 doses for primary D-I-H series. The average frequency of medical visits for vaccination showed a significant difference across the 3 groups classified by DTaP components in every birth cohort (p < 0.001).
UNASSIGNED: After the introduction of DTaP-IPV/Hib, most infants completed the primary D-I-H series with the combination vaccine and there was a significant reduction in the average number of medical visits for vaccination. Our findings provide important insights for countries considering the introduction of combination vaccines into their NIP.