背景:肿瘤免疫治疗不仅可以消除原发病灶,还会产生长期免疫记忆,有效抑制肿瘤的转移和复发。然而,免疫疗法在临床实践中也显示出许多局限性。近年来,纳米材料和免疫疗法的结合为完全消除肿瘤带来了新的光,其出色的抗肿瘤作用和可忽略的副作用。
方法:利用WebofScience核心论集(WOSCC)检索并获取WOSCC成立以来抗肿瘤纳米免疫治疗的相关文献。Bibliometrix,VOSviewer,CiteSpace,GraphPad棱镜,采用Excel进行统计分析和可视化。年产量,积极的机构,核心期刊,主要作者,关键词,主要国家,关键文档,并对纳入期刊的影响因子进行评价。
结果:2004年至2022年共纳入443项相关研究,文章的年增长率达到惊人的16.85%。就出版物数量而言,领先的国家是中国和美国。控释杂志,生物材料,ActaBiomaterialia,Theranostics,先进材料,ACSNano是核心期刊,发表有关该领域最新进展的高质量文献。集中于树突状细胞和药物递送的文章在该领域占很大比例。关键词如调节性T细胞,肿瘤微环境,免疫检查点封锁,药物输送,光动力疗法,光热疗法,肿瘤相关巨噬细胞是成熟度较高的最热主题之一.树突状细胞,疫苗,T细胞将成为未来研究的热点和新兴课题。
结论:纳米材料与抗肿瘤免疫治疗的联合治疗,即抗肿瘤纳米免疫疗法日益受到重视。抗肿瘤纳米免疫疗法正在经历从简单到复杂的转变,从表型到机制。
BACKGROUND: Tumor immunotherapy can not only eliminate the primary lesion, but also produce long-term immune memory, effectively inhibiting tumor metastasis and recurrence. However, immunotherapy also showed plenty of limitations in clinical practice. In recent years, the combination of nanomaterials and immunotherapy has brought new light for completely eliminating tumors with its fabulous anti-tumor effects and negligible side effects.
METHODS: The Core Collection of Web of Science (WOSCC) was used to retrieve and obtain relevant literatures on antitumor nano-immunotherapy since the establishment of the WOSCC. Bibliometrix, VOSviewer, CiteSpace, GraphPad Prism, and Excel were adopted to perform statistical analysis and visualization. The annual output, active institutions, core journals, main authors, keywords, major countries, key documents, and impact factor of the included journals were evaluated.
RESULTS: A total of 443 related studies were enrolled from 2004 to 2022, and the annual growth rate of articles reached an astonishing 16.85%. The leading countries in terms of number of publications were China and the United States. Journal of Controlled Release, Biomaterials, Acta Biomaterialia, Theranostics, Advanced Materials, and ACS Nano were core journals publishing high-quality literature on the latest advances in the field. Articles focused on dendritic cells and drug delivery accounted for a large percentage in this field. Key words such as regulatory T cells, tumor microenvironment, immune checkpoint blockade, drug delivery, photodynamic therapy, photothermal therapy, tumor-associated macrophages were among the hottest themes with high maturity. Dendritic cells, vaccine, and T cells tend to become the popular and emerging research topics in the future.
CONCLUSIONS: The combined treatment of nanomaterials and antitumor immunotherapy, namely antitumor nano-immunotherapy has been paid increasing attention. Antitumor nano-immunotherapy is undergoing a transition from simple to complex, from phenotype to mechanism.