■马齿莲地上部分的煎剂和输液。,尤其是叶子和茎,被尼日利亚的传统医学从业者用来提高人类的生育能力。关于将这种植物用于所述目的及其功效的文献的匮乏促使了这项研究。研究了马齿轮轴亲脂性和亲水性叶提取物对发情周期的影响,白化病大鼠在发情周期和卵巢和子宫组织形态学的各个阶段的女性性激素。
实验动物随机分为7组,每组5只大鼠。A组(对照组)接受0.5毫升20%吐温80(载体),B组,C&D分别接受125、250和500mg/kg的亲脂性提取物,F&G分别接受125、250和500mg/kg的亲水性提取物21天。每天评估发情周期。最后,收集血液样本(激素)和卵巢和子宫切片(组织结构)。
■两种提取物对发情周期均无明显影响(p>0.05),卵巢和子宫组织结构和女性性激素,除了在发情期,其中记录到LH和FSH显着降低(p<0.05)。本研究中使用的P.oleracea可能对女性生殖系统产生有害影响,如发情期激素的破坏所示。这可以构成反驳使用紫花苜蓿叶提取物增强生育力的基础,因为它已被证明会影响与卵泡发生有关的促性腺激素。
UNASSIGNED: Decoctions and infusions from the aerial parts of Portulaca oleracea Linn., especially the leaves and stems, are used by traditional medicine practitioners in Nigeria to enhance fertility in humans. The scarcity of literature on the use of this plant for the said purpose as well as its efficacy prompted this research. Study investigated effect of lipophilic and hydrophilic leaf extracts of Portulaca oleracea on oestrous cycle, female sex hormones at various phases of oestrous cycle and ovarian and uterine histomorphology in albino rats.
UNASSIGNED: Experimental animals were randomly divided into 7 groups of 5 rats each. Group A (control) received 0.5 ml 20% Tween 80 (vehicle), groups B, C & D received 125, 250 & 500 mg/kg of the lipophilic extract respectively and E, F & G received 125, 250 & 500 mg/kg of the hydrophilic extract respectively for 21 days. Oestrous cycle was assessed daily. At the end, blood samples (for hormones) and ovarian &uterine sections (histoarchitecture) were collected.
UNASSIGNED: Both extracts had no significant (p > 0.05) effect on oestrous cycle, ovarian & uterine histoarchitecture and female sex hormones except at proestrus phase where significant (p < 0.05) decrease in LH and FSH was recorded. P.oleracea as used in this study may have deleterious effect on female reproductive system as shown by the disruption of the hormones at proestrus phase. This can form a basis to refute the use of P.oleracea leaf extracts in enhancing fertility as it has been shown to affect the gonadotropins involved in folliculogenesis.