背景:先前已确定胆红素与心脏代谢结果之间的联系与轻度高胆红素血症对健康的积极影响。另一方面,最近的证据表明低循环胆红素水平与肥胖之间存在关联.这项研究旨在评估总胆红素水平与肥胖相关的代谢和心血管危险因素的关系。
方法:本研究纳入年龄和性别相匹配的50名肥胖成年人和50名健康对照。人体测量,空腹血糖,空腹胰岛素,胰岛素抵抗的稳态模型评估(HOMA-IR),HOMA-β(%),脂质概况,单核细胞与淋巴细胞比率(MLR),中性粒细胞与淋巴细胞比率(NLR),血小板与淋巴细胞比率(PLR),尿酸,γ-谷氨酰转肽酶(GGT),评估AST/ALT比值和总胆红素。
结果:总胆红素,高密度脂蛋白胆固醇(HDL-C)和AST/ALT比值显著降低,而空腹胰岛素,HOMA-IR,总胆固醇,甘油三酯,低密度脂蛋白胆固醇,NLR,肥胖成人的尿酸和GGT显著高于健康对照组.胆红素与体重指数呈负相关,腰围,空腹胰岛素,HOMA-IR,NLR,PLR,尿酸,与HDL-C呈正相关HDL-C和NLR是总胆红素的独立预测变量。
结论:在所有研究的心脏代谢危险因素中,HDL-C和NRL是与肥胖成人总胆红素水平最密切相关的变量。
BACKGROUND: The link between bilirubin and cardiometabolic outcomes has been previously identified with positive health effects of mild hyperbilirubinaemia. On the other hand, recent evidence has suggested an association between low circulating bilirubin levels and obesity. This study was conducted to assess the association of total bilirubin levels with metabolic and cardiovascular risk factors related to obesity.
METHODS: A total of 50 obese adults and 50 healthy controls matched for age and sex were enrolled in this study. Anthropometric measurements, fasting glucose, fasting insulin, homeostasis model assessment of insulin resistance (HOMA-IR), HOMA- β (%), lipids profile, monocyte to lymphocyte ratio (MLR), neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), uric acid, gamma glutamyl transpeptidase (GGT), AST/ALT ratio and total bilirubin were assessed.
RESULTS: Total bilirubin, high density lipoprotein cholesterol (HDL-C) and AST/ALT ratio were significantly lower, whereas fasting insulin, HOMA-IR, total cholesterol, triglycerides, low density lipoprotein cholesterol, NLR, uric acid and GGT were significantly higher in obese adults than in healthy controls. Bilirubin was negatively associated with body mass index, waist circumference, fasting insulin, HOMA-IR, NLR, PLR, uric acid, and positively associated with HDL-C. HDL-C and NLR were the independent predictor variables of total bilirubin.
CONCLUSIONS: Among all the studied cardio-metabolic risk factors, HDL-C and
NRL are the most closely associated variables with total bilirubin levels in obese adults.