背景:1,3-二苯基丙烷-1,3-二酮(1)是乙酰丙酮β-二酮,其中两个甲基都被苯基取代。它是甘草根提取物(甘草)的成分,具有抗诱变和抗癌特性。它的功能是代谢产物,一种抗诱变剂,和抗肿瘤药.它是芳香酮和β-二酮。1,3-二苯基丙烷-1,3-二酮(1)主要用于PVC软硬材料,包括盘子,电影,profiles,管道,和配件。
目的:本研究旨在研究1,3-二苯基丙烷-1,3-二酮(1)用于合成多种新的杂环化合物的实用性,如硫代酰胺,噻唑烷,噻吩-2-腈,苯基噻唑,噻二唑-2-羧酸盐,1,3,4-噻二唑衍生物,2-溴-1,3-二苯基丙烷-1,3-二酮,新取代的苯并[1,4]噻嗪,苯基喹喔啉,和咪唑并[1,2-b][1,2,4]三唑衍生物的潜在生物活性方法:1,3-二苯基丙烷-1,3-二酮(1)用作合成3-氧代-N的起始化合物,3-二苯基-2-(苯基羰基)丙硫酰胺(3)和2-溴-1,3-二苯基丙烷-1,3-二酮(25),可用于进一步的制备。还对一些合成化合物的5α-还原酶抑制剂活性进行了体内测试;建立了ED50和LD50数据,结果:使用IR,1H-NMR,质谱,和元素分析,所有产生的化合物的结构被阐明。这些制备的化合物中的一些被报道为5α-还原酶抑制剂。
结论:新的杂环化合物可以通过1,3-二苯基丙烷-1,3-二酮(1)形成,这些化合物中的一些可以作为5α-还原酶抑制剂。
BACKGROUND: 1,3-Diphenylpropane-1,3-dione (1) is an acetylacetone β-diketone in which both of the methyl groups have been replaced with phenyl groups. It is a component of licorice root extract (Glycyrrhiza glabra) and has anti-mutagenic and anti-cancer properties. It functions as a metabolite, an anti-mutagen, and an anti-neoplastic agent. It is an aromatic ketone and a β-diketone. 1,3-Diphenylpropane-1,3-dione (1) is primarily used in PVC hard and soft materials, including plates, films, profiles, pipes, and fittings.
OBJECTIVE: This research aims to examine the utility of 1,3-diphenylpropane-1,3-dione (1) for the synthesis of a variety of new heterocyclic compounds, such as thioamide, thiazolidine, thiophene-2-carbonitrile, phenylthiazole, thiadiazole-2-carboxylate, 1,3,4-thiadiazole derivatives, 2-bromo-1,3-diphenylpropane-1,3-dione, new substituted benzo[1,4]thiazines, phenylquinoxalines, and imidazo[1,2-b][1,2,4]triazole derivatives of potential biological activity Methods: 1,3-Diphenylpropane-1,3-dione (1) was used as a starting compound for the synthesis of 3-oxo-N,3-diphenyl-2-(phenylcarbonyl)propanethioamide (3) and 2-bromo-1,3-diphenylpropane-1,3-dione (25), which can be used for further preparations. The 5α-reductase inhibitor activity of some of the synthesized compounds was also tested in vivo; the ED50 and LD50 data were established, Results: Using IR, 1H-NMR, mass spectroscopy, and elemental analysis, the structures of all produced compounds were elucidated. Some of these prepared compounds were reported as 5α-reductase inhibitors.
CONCLUSIONS: New heterocyclic compounds can be formed via 1,3-diphenylpropane-1,3-dione (1), and some of these compounds can act as 5α-reductase inhibitors.