本研究探讨N-乙酰半胱氨酸(NAC)联合盐酸氨溴索(AH)对临床症状的影响。C反应蛋白(CRP),肺炎患儿的降钙素原(PCT)水平。
将98例肺炎患儿按随机数字表法分为对照组和观察组。观察组给予NAC,对照组给予AH。观察治疗效果,临床症状消失时间和炎症因子水平,肺功能参数,血气分析参数,和免疫球蛋白进行测量。对不良反应发生率进行统计学分析。
观察组有效率高于对照组(p<0.05)。退热时间,咳嗽消失时间,观察组肺部啰音消失时间明显短于对照组(p<0.05)。治疗后,CRP和PCT较低(p<0.05),FVC,FEV1和FEV1/FVC较高,PaCO2较低,PaO2和SaO2较高,还有IgA,IgG,IgM,观察组C3水平高于对照组(p<0.05)。两组不良反应发生率差异无统计学意义(p>0.05)。
NAC联合AH治疗小儿肺炎可有效缓解临床症状,减少炎症因子,改善肺功能和免疫功能。
This study investigated the effects of N-Acetylcysteine (NAC) combined with Ambroxol Hydrochloride (AH) on clinical symptoms, C-Reactive Protein (CRP), and Procalcitonin (PCT) levels in children with pneumonia.
A total of 98 children with pneumonia were assigned to the control group and observation group by random number table method. NAC was administered to the observation group and AH was given to the control group. The therapeutic effect was observed, the disappearance time of clinical symptoms and levels of inflammatory factors, lung function parameters, blood gas analysis parameters, and immunoglobulin were measured. The incidence of adverse reactions was statistically analyzed.
A higher effective rate was observed in the observation group than in the control group (p < 0.05). Antipyretic time, cough disappearance time, and lung rale disappearance time in the observation group were shorter than those in the control group (p < 0.05). After treatment, CRP and PCT were lower (p < 0.05), FVC, FEV1, and FEV1/FVC were higher, PaCO2 was lower, PaO2 and SaO2 were higher, and IgA, IgG, IgM, and C3 were higher in the observation group than those in the control group (p < 0.05). The incidence of adverse reactions between the two groups was not significantly different (p > 0.05).
NAC combined with AH is effective in the treatment of pediatric pneumonia by effectively alleviating clinical symptoms, reducing inflammatory factors, and improving lung function and immune function.