乙型肝炎病毒(HBV)感染导致乙型肝炎,这是肝细胞癌(HCC)的最常见原因之一。宿主免疫基因的单核苷酸多态性(SNPs)可能影响HBV感染,病毒清除,和治疗效果。然而,几项研究的相互矛盾的作用表明了对不同人群的进一步分析。从云南人群中收集448例HBV患者和配对对照者的全血和生化指标,以研究IFNL4及其下游基因(MxA和MxB)的遗传作用。基因型,等位基因,分析了HBV患者和对照组的七个SNP(rs11322783,rs117648444,rs2071430,rs17000900,rs9982944,rs408825和rs2838029)的单倍型频率。然而,SNPs与HBV感染之间未发现相关性.然后,在7个SNP的不同基因型的HBV患者中评价生化指标水平。结果表明,肝功能指标水平(包括丙氨酸转氨酶(ALT),天冬氨酸转氨酶(AST),总胆红素(TBIL),直接胆红素(DBIL),间接胆红素(IBIL),和白蛋白(ALB))受HBV患者SNPs基因型的影响。此外,当HBV患者分为HBsAg阳性和阴性组,SNP基因型与生化指标之间仍然存在关联。此外,虽然IFNL4,MxA,MxB基因与云南人群HBV感染无显著相关性,这些基因可以通过与云南HBV患者的生化指标水平关联间接影响疾病进展。
Hepatitis B virus (HBV) infection causes Hepatitis B, which is one of the most common causes of hepatocellular carcinoma (HCC). The single nucleotide polymorphisms (SNPs) of the host immune genes could impact HBV infection, viral clearance, and treatment effect. However, the contradictory roles of several studies suggest further analysis of various populations. The whole blood and biochemical indexes of 448 HBV patients and matched controls were collected from the Yunnan population to investigate the genetic roles of IFNL4 and the downstream genes (MxA and
MxB). The genotypes, alleles, and haplotypes frequencies of the seven SNPs (rs11322783, rs117648444, rs2071430, rs17000900, rs9982944, rs408825, and rs2838029) from the HBV patients and controls were analyzed. However, no association was identified between the SNPs and HBV infection. Then, biochemical index levels were evaluated among the HBV patients with different genotypes of the seven SNPs. The results indicated that the liver function index levels (including alanine transaminase (ALT), aspartate transaminase (AST), total bilirubin (TBIL), direct bilirubin (DBIL), indirect bilirubin (IBIL), and albumin (ALB)) were influenced by the genotypes of the SNPs in HBV patients. Moreover, when the HBV patients were divided into HBsAg-positive and -negative groups, the association between the SNP genotypes and the biochemical indexes still existed. In addition, although the genetic polymorphisms in the IFNL4, MxA, and
MxB genes were not significantly associated with HBV infection in the Yunnan population, these genes could indirectly influence disease progression by associating with the biochemical index levels of Yunnan HBV patients.