背景:全身振动(WBV)是用于疾病预防和康复的常用体育锻炼。最近的研究表明WBV的作用机制可能与其抗炎作用有关。然而,其对不同炎症介质的调节作用仍存在争议.这项研究的目的是进行荟萃分析,以重新确认WBV运动对各种炎症因子的影响。
方法:PubMed,截至2023年9月,对EMBASE和Cochrane图书馆数据库进行了搜索,以收集将WBV与对照(或试验后)进行比较的所有文章。效应大小表示为标准化平均差(SMD)和95%置信区间(CI)。
结果:共纳入了31项符合条件的研究,包括14项临床前研究和17项临床研究。临床前研究的荟萃分析表明,与对照组相比,WBV运动可显著降低IL-6水平(SMD:-1.03,95%CI:-1.93,-0.13),TNF-α(SMD:-1.36,95%CI:-2.54,-0.17)(用于疾病亚组),IL-1β(SMD:-2.20,95%CI:-3.24,-1.15),IFN-γ(SMD:-1.91,95%CI:-2.71,-1.12),总体IL-4(SMD:-0.71,95%CI:-1.39,-0.03)和IL-17(SMD:-1.32,95%CI:-2.05,-0.59)。临床研究汇总显示,WBV运动显着降低TNF-α水平(WBV与对照组:SMD:-1.11,95%CI:-2.16,-0.06;后与前:SMD:-1.29,95%CI:-1.91,-0.67),CRP(SMD:-3.59,95%CI:-6.36,-0.82,P=0.011)并提高IL-10水平(WBV与对照组:SMD:2.90,95%CI:1.10,4.71;后与前:SMD:1.75,95%CI:0.64,2.87)和IL-6(SMD:0.91,95%CI:0.31,1.52)(亚健康组)
结论:WBV可能是炎症性疾病的有效预防和康复工具。
BACKGROUND: Whole-body vibration (WBV) is a commonly used physical exercise for disease prevention and rehabilitation. Recent studies indicated the beneficial mechanism of WBV may be associated with its anti-inflammatory potential, however, its regulatory roles on different inflammatory mediators remained controversial. The aim of this study was to perform a meta-analysis to re-confirm the effects of WBV exercise on various inflammatory factors.
METHODS: The PubMed, EMBASE and Cochrane Library databases were searched up to September 2023 to collect all articles comparing WBV with control (or post-pre trials). The effect size was expressed as the standardized mean difference (SMD) and 95% confidence intervals (CI).
RESULTS: A total of 31 eligible studies were included, including 14 pre-clinical and 17 clinical studies. The meta-analysis of pre-clinical studies showed that compared with the control group, WBV exercise could significantly reduce the level of IL-6 (SMD: -1.03, 95% CI: -1.93, -0.13), TNF-α (SMD: -1.36, 95% CI: -2.54, -0.17) (for disease subgroup), IL-1β (SMD: -2.20, 95% CI: -3.24, -1.15), IFN-γ (SMD: -1.91, 95% CI: -2.71, -1.12), IL-4 (SMD: -0.71, 95% CI: -1.39, -0.03) and IL-17 (SMD: -1.32, 95% CI: -2.05, -0.59) overall. Pooling of clinical studies revealed WBV exercise significantly reduced the level of TNF-α (WBV vs control: SMD: -1.11, 95% CI: -2.16, -0.06; post vs pre: SMD: -1.29, 95% CI: -1.91, -0.67), CRP (SMD: -3.59, 95% CI: -6.36, -0.82, P = 0.011) and enhanced the level of IL-10 (WBV vs control: SMD: 2.90, 95% CI: 1.10, 4.71; post vs pre: SMD: 1.75, 95% CI: 0.64, 2.87) and IL-6 (SMD: 0.91, 95% CI: 0.31, 1.52) (healthy subgroup).
CONCLUSIONS: WBV may be an effective prevention and rehabilitation tool for inflammatory diseases.