背景:阿尔茨海默病(AD)是一种特殊类型的痴呆,目前缺乏明确的治疗和治愈方法。通过改变一个人的生活方式,可以降低患AD的风险并减轻其严重程度。规律饮食,和饮酒习惯。
目的:本研究的目的是研究与健康对照组相比,AD患者的日常饮食模式。重点关注营养平衡及其对AD的影响。
方法:本研究结合了多因素分析(MFA)来评估饮食模式,并采用随机森林(RF)分类器和稀疏逻辑回归(SLR)进行变量重要性分析,以确定与AD显著相关的食物项目。
结果:MFA揭示了AD患者每日食用加工食品和肉类之间的数据趋势和强相关性(Lg=0.92,RV=0.65)。相比之下,在健康控制(HC)组中,任何每日食用的食物类别均未发现显著相关.肉类馅饼等食品,汉堡包,火腿,香肠,牛肉,辣椒,在RF和SLR分析中,白菜被确定为与AD相关的重要变量。
结论:来自MFA的发现表明,日常饮食的多样性或平衡可能在AD的发展中起潜在作用。RF和SLR分类显示在加工食品中,尤其是熟食肉类和肉类食品,与AD有关。
BACKGROUND: Alzheimer\'s disease (AD) is a particular type of dementia that currently lacks a definitive treatment and cure. It is possible to reduce the risk of developing AD and mitigate its severity through modifications to one\'s lifestyle, regular diet, and alcohol-drinking habits.
OBJECTIVE: The objective of this study is to examine the daily dietary patterns of individuals with AD compared to healthy controls, with a focus on nutritional balance and its impact on AD.
METHODS: This study incorporated multiple-factor analysis (MFA) to evaluate dietary patterns and employed Random Forest (RF) classifier and Sparse Logistic Regression (SLR) for Variable Importance analysis to identify food items significantly associated with AD.
RESULTS: MFA revealed trends in the data and a strong correlation (Lg = 0.92, RV = 0.65) between the daily consumption of processed food and meat items in AD patients. In contrast, no significant relationship was found for any daily consumed food categories within the healthy control (HC) group. Food items such as meat pie, hamburger, ham, sausages, beef, capsicum, and cabbage were identified as important variables associated with AD in RF and SLR analyses.
CONCLUSIONS: The findings from MFA indicated that the diversity or equilibrium of daily diet might play a potential role in AD development. RF and SLR classifications exhibit among the processed foods, especially deli meats and food made with meat items, are associated with AD.