■诺卡氏菌是导致牛乳腺炎和肺,皮肤,人类的中枢神经系统感染。据零星报道,牛流产。这项研究的目的是分析大韩民国N.farcinica引起的牛流产的病理学发现,并确定N.farcinica分离株的耐药性和基因型特征。
■将3例牛流产病例提交动植物检疫机构进行鉴别诊断。严重的,一个胎儿在触诊整个肺叶后表现出严重的肺实变。组织学上,在所有胎儿中均观察到坏死性肉芽肿性间质性肺炎;胎儿有严重病变,表现为肠系膜淋巴结坏死性淋巴结炎和耳部坏死性皮炎。从所有胎儿的鼻孔内容物和肺中分离出N.farcinica分离株。最后,两例被诊断为因N.farcinica流产,其中一人被诊断为与牛病毒性腹泻病毒同时感染的土豆泥流产。根据多位点序列分析,所有分离株都被鉴定为N.farcinica,并被确定与人类分离株遗传相关。两种法氏奈瑟菌分离株对甲氧苄啶-磺胺甲恶唑耐药,它被推荐作为人类颈心感染的第一种治疗方法。
■这是大韩民国首例由N.farcinica引起的牛流产的病理报告。需要进一步的研究来在表型和基因型上表征具有各种来源的土豆菌分离株,并持续监测抗微生物耐药模式。
UNASSIGNED: Nocardia farcinica is an opportunistic bacterium that causes bovine mastitis and pulmonary, cutaneous, and central nervous system infections in humans. Bovine abortion caused by N. farcinica has been sporadically reported. The purpose of this study was to analyze the pathological findings of bovine abortions caused by N. farcinica in the Republic of Korea and determine the antimicrobial resistance and genotypical characteristics of N. farcinica isolates.
UNASSIGNED: Three cases of bovine abortions were submitted to the Animal and Plant Quarantine Agency for differential diagnosis. Grossly, one fetus showed severe lung consolidation following palpation of the entire lobes. Histologically, necrotizing granulomatous interstitial pneumonia was observed in all fetuses; a fetus with a gross lesion demonstrated necrotizing lymphadenitis in the mesenteric lymph nodes and necrotizing dermatitis in the ear. N. farcinica isolates were isolated from the abomasal contents and lungs of all fetuses. Finally, two cases were diagnosed as abortions due to N. farcinica, and one was diagnosed as an N. farcinica abortion coinfected with bovine viral diarrhea virus. According to the multilocus sequence analysis, all isolates were identified as N. farcinica and were determined to be genetically related to isolates from humans. Two N. farcinica isolates were resistant to trimethoprim-sulfamethoxazole, which is recommended as the first treatment for human nocardial infections.
UNASSIGNED: This is the first pathological report of bovine abortion caused by N. farcinica in the Republic of Korea. Further studies are needed to phenotypically and genotypically characterize N. farcinica isolates with various sources and continuously monitor antimicrobial resistance patterns.