未经批准:牙周炎影响全球多达10亿人,并已被证明与几种全身性炎症有关。这项研究调查了两种多因素疾病之间的特定关系:炎症性肠病(IBD)和牙周炎。要深入探究这个问题,我们单独调查IBD患者是否有更高的机会发展牙周炎,同样,牙周炎患者是否有更高的机会发展IBD。
UNASSIGNED:在三个数据库中进行了系统搜索:MEDLINE,Cochrane试验,和Embase,2021年10月26日该协议已在PROSPERO注册。包括从任一方向调查IBD与牙周炎之间关联的所有合格研究。纽卡斯尔-渥太华量表用于评估偏倚风险。作为主要结果,我们调查了IBD和牙周炎的患病率,并计算了比值比(OR)。我们的次要结果包括比较IBD患者与无IBD患者的临床牙周结果。
未经评估:系统搜索产生了1,715条记录,其中14个符合定性合成条件,8个符合定量合成条件。根据主要结果的结果,IBD诊断与牙周炎的几率明显升高相关:OR=2.65(CI:2.09-3.36,I2=0(CI:0-0.75))。对于子组分析,我们分别调查了克罗恩病(CD)患者的几率:OR=2.22(CI:1.49~3.31,I2=0.05(CI:0~0.76))和溃疡性结肠炎(UC)患者的几率:OR=3.52(CI:2.56~4.83,I2=0(CI:0~0.75));所有病例的几率均显著较高.两项研究调查了牙周炎患者是否更容易患IBD,两者都发现牙周炎与后续UC的风险显着相关,但不是随后的CD。然而,需要更多的研究来证明这种关联。
UNASSIGNED:我们的分析证实,IBD患者患牙周炎的几率更高,并且是牙科领域的高风险人群。牙医和胃肠病学家都应该意识到这种关系,并且应该比健康人群更多地强调预防的重要性。
UNASSIGNED:[https://www.crd.约克。AC.英国/普华永道/],标识符[CRD42021286161]。
UNASSIGNED: Periodontitis affects up to one billion people worldwide, and has been proven to be associated with several systemic inflammatory conditions. This study investigates the specific relationship between two multifactorial diseases: Inflammatory bowel disease (IBD) and periodontitis. To thoroughly explore this issue, we investigated separately whether IBD patients have a higher chance of developing periodontitis, and equally, whether patients with periodontitis have a higher chance of developing IBD.
UNASSIGNED: The systematic search was performed in three databases: MEDLINE, Cochrane Trials, and Embase, up to 26 October 2021. The protocol was registered in PROSPERO. All eligible studies investigating the association between IBD and periodontitis from either direction were included. The Newcastle-Ottawa Scale was used to assess the risk of bias. As a primary outcome, we investigated the prevalence of IBD and periodontitis, and calculated the odds ratio (OR). Our secondary outcomes involved comparing the clinical periodontal outcomes of IBD patients to those of IBD-free patients.
UNASSIGNED: The systematic search resulted in 1,715 records, 14 of which were eligible for qualitative synthesis and 8 for quantitative synthesis. On the basis of the results of the primary outcome, IBD diagnosis was associated with significantly higher odds of periodontitis: OR = 2.65 (CI: 2.09-3.36, I 2 = 0 (CI: 0-0.75)). For subgroup analysis, we investigated separately the odds in Crohn\'s disease (CD) patients: OR = 2.22 (CI: 1.49-3.31, I 2 = 0.05 (CI: 0-0.76)) and in ulcerative colitis (UC) patients: OR = 3.52 (CI: 2.56 to 4.83, I 2 = 0 (CI: 0-0.75)); the odds were significantly higher in all cases. Two studies investigated whether patients with periodontitis were more susceptible to IBD, and both found that periodontitis was significantly associated with the risk of subsequent UC, but not with subsequent CD. However, more studies are needed to prove an association.
UNASSIGNED: Our analysis confirmed that IBD patients have a higher chance of developing periodontitis, and are a higher risk population in dentistry. Both dentists and gastroenterologists should be aware of this relationship and should emphasize the importance of prevention even more than in the healthy population.
UNASSIGNED: [https://www.crd.york.ac.uk/prospero/], identifier [CRD42021286161].