UNASSIGNED: Dyslexia is a neurological disorder that affects an individual\'s language processing abilities. Early care and intervention can help dyslexic individuals succeed academically and socially. Recent developments in deep learning (DL) approaches motivate researchers to build dyslexia detection models (DDMs). DL approaches facilitate the integration of multi-modality data. However, there are few multi-modality-based DDMs.
UNASSIGNED: In this study, the authors built a DL-based DDM using multi-modality data. A squeeze and excitation (SE) integrated MobileNet V3 model, self-attention mechanisms (SA) based EfficientNet B7 model, and early stopping and SA-based Bi-directional long short-term memory (Bi-LSTM) models were developed to extract features from magnetic resonance imaging (MRI), functional MRI, and electroencephalography (EEG) data. In addition, the authors fine-tuned the LightGBM model using the Hyperband optimization technique to detect dyslexia using the extracted features. Three datasets containing FMRI, MRI, and EEG data were used to evaluate the performance of the proposed DDM.
UNASSIGNED: The findings supported the significance of the proposed DDM in detecting dyslexia with limited computational resources. The proposed model outperformed the existing DDMs by producing an optimal accuracy of 98.9%, 98.6%, and 98.8% for the FMRI, MRI, and EEG datasets, respectively. Healthcare centers and educational institutions can benefit from the proposed model to identify dyslexia in the initial stages. The interpretability of the proposed model can be improved by integrating vision transformers-based feature extraction.

Alzheimer\'s disease (AD) is an irreversible central nervous degenerative disease, while mild cognitive impairment (MCI) is a precursor state of AD. Accurate early diagnosis of AD is conducive to the prevention and early intervention treatment of AD. Although some computational methods have been developed for AD diagnosis, most employ only neuroimaging, ignoring other data (e.g., genetic, clinical) that may have potential disease information. In addition, the results of some methods lack interpretability. In this work, we proposed a novel method (called DANMLP) of joining dual attention convolutional neural network (CNN) and multilayer perceptron (MLP) for computer-aided AD diagnosis by integrating multi-modality data of the structural magnetic resonance imaging (sMRI), clinical data (i.e., demographics, neuropsychology), and APOE genetic data. Our DANMLP consists of four primary components: (1) the Patch-CNN for extracting the image characteristics from each local patch, (2) the position self-attention block for capturing the dependencies between features within a patch, (3) the channel self-attention block for capturing dependencies of inter-patch features, (4) two MLP networks for extracting the clinical features and outputting the AD classification results, respectively. Compared with other state-of-the-art methods in the 5CV test, DANMLP achieves 93% and 82.4% classification accuracy for the AD vs. MCI and MCI vs. NC tasks on the ADNI database, which is 0.2%∼15.2% and 3.4%∼26.8% higher than that of other five methods, respectively. The individualized visualization of focal areas can also help clinicians in the early diagnosis of AD. These results indicate that DANMLP can be effectively used for diagnosing AD and MCI patients.

In obstetric sonography, the quality of acquisition of ultrasound scan video is crucial for accurate (manual or automated) biometric measurement and fetal health assessment. However, the nature of fetal ultrasound involves free-hand probe manipulation and this can make it challenging to capture high-quality videos for fetal biometry, especially for the less-experienced sonographer. Manually checking the quality of acquired videos would be time-consuming, subjective and requires a comprehensive understanding of fetal anatomy. Thus, it would be advantageous to develop an automatic quality assessment method to support video standardization and improve diagnostic accuracy of video-based analysis. In this paper, we propose a general and purely data-driven video-based quality assessment framework which directly learns a distinguishable feature representation from high-quality ultrasound videos alone, without anatomical annotations. Our solution effectively utilizes both spatial and temporal information of ultrasound videos. The spatio-temporal representation is learned by a bi-directional reconstruction between the video space and the feature space, enhanced by a key-query memory module proposed in the feature space. To further improve performance, two additional modalities are introduced in training which are the sonographer gaze and optical flow derived from the video. Two different clinical quality assessment tasks in fetal ultrasound are considered in our experiments, i.e., measurement of the fetal head circumference and cerebellar diameter; in both of these, low-quality videos are detected by the large reconstruction error in the feature space. Extensive experimental evaluation demonstrates the merits of our approach.

Recent technological advances have made it possible to measure multiple types of many features in biomedical studies. However, some data types or features may not be measured for all study subjects because of cost or other constraints. We use a latent variable model to characterize the relationships across and within data types and to infer missing values from observed data. We develop a penalized-likelihood approach for variable selection and parameter estimation and devise an efficient expectation-maximization algorithm to implement our approach. We establish the asymptotic properties of the proposed estimators when the number of features increases at a polynomial rate of the sample size. Finally, we demonstrate the usefulness of the proposed methods using extensive simulation studies and provide an application to a motivating multi-platform genomics study.

UNASSIGNED: Recurrence risk evaluation is clinically significant for patients with locally advanced cervical cancer (LACC). We investigated the ability of transformer network in recurrence risk stratification of LACC based on computed tomography (CT) and magnetic resonance (MR) images.
UNASSIGNED: A total of 104 patients with pathologically diagnosed LACC between July 2017 and December 2021 were enrolled in this study. All patients underwent CT and MR scanning, and their recurrence status was identified by the biopsy. We randomly divided patients into training cohort (48 cases, non-recurrence: recurrence = 37: 11), validation cohort (21 cases, non-recurrence: recurrence = 16: 5), and testing cohort (35 cases, non-recurrence: recurrence = 27: 8), upon which we extracted 1989, 882 and 315 patches for model\'s development, validation and evaluation, respectively. The transformer network consisted of three modality fusion modules to extract multi-modality and multi-scale information, and a fully-connected module to perform recurrence risk prediction. The model\'s prediction performance was assessed by six metrics, including the area under the receiver operating characteristic curve (AUC), accuracy, f1-score, sensitivity, specificity and precision. Univariate analysis with F-test and T-test were conducted for statistical analysis.
UNASSIGNED: The proposed transformer network is superior to conventional radiomics methods and other deep learning networks in both training, validation and testing cohorts. Particularly, in testing cohort, the transformer network achieved the highest AUC of 0.819 ± 0.038, while four conventional radiomics methods and two deep learning networks got the AUCs of 0.680 ± 0.050, 0.720 ± 0.068, 0.777 ± 0.048, 0.691 ± 0.103, 0.743 ± 0.022 and 0.733 ± 0.027, respectively.
UNASSIGNED: The multi-modality transformer network showed promising performance in recurrence risk stratification of LACC and may be used as an effective tool to help clinicians make clinical decisions.

Biomedical multi-modality data (also named multi-omics data) refer to data that span different types and derive from multiple sources in clinical practices (e.g. gene sequences, proteomics and histopathological images), which can provide comprehensive perspectives for cancers and generally improve the performance of survival models. However, the performance improvement of multi-modality survival models may be hindered by two key issues as follows: (1) how to learn and fuse modality-sharable and modality-individual representations from multi-modality data; (2) how to explore the potential risk-aware characteristics in each risk subgroup, which is beneficial to risk stratification and prognosis evaluation. Additionally, learning-based survival models generally refer to numerous hyper-parameters, which requires time-consuming parameter setting and might result in a suboptimal solution. In this paper, we propose an adaptive risk-aware sharable and individual subspace learning method for cancer survival analysis. The proposed method jointly learns sharable and individual subspaces from multi-modality data, whereas two auxiliary terms (i.e. intra-modality complementarity and inter-modality incoherence) are developed to preserve the complementary and distinctive properties of each modality. Moreover, it equips with a grouping co-expression constraint for obtaining risk-aware representation and preserving local consistency. Furthermore, an adaptive-weighted strategy is employed to efficiently estimate crucial parameters during the training stage. Experimental results on three public datasets demonstrate the superiority of our proposed model.

Early detection and treatment of Alzheimer\'s Disease (AD) are significant. Recently, multi-modality imaging data have promoted the development of the automatic diagnosis of AD. This paper proposes a method based on latent feature fusion to make full use of multi-modality image data information. Specifically, we learn a specific projection matrix for each modality by introducing a binary label matrix and local geometry constraints and then project the original features of each modality into a low-dimensional target space. In this space, we fuse latent feature representations of different modalities for AD classification. The experimental results on Alzheimer\'s Disease Neuroimaging Initiative database demonstrate the proposed methods effectiveness in classifying AD.

In modern biomedical classification applications, data are often collected from multiple modalities, ranging from various omics technologies to brain scans. As different modalities provide complementary information, classifiers using multi-modality data usually have good classification performance. However, in many studies, due to the high cost of measures, in a lot of samples, some modalities are missing and therefore all data from those modalities are missing completely. In this case, the training data set is a block-missing multi-modality data set. In this paper, considering such classification problems, we develop a new weighted nearest neighbors classifier, called the integrative nearest neighbor (INN) classifier. INN harnesses all available information in the training data set and the feature vector of the test data point effectively to predict the class label of the test data point without deleting or imputing any missing data. Given a test data point, INN determines the weights on the training samples adaptively by minimizing the worst-case upper bound on the estimation error of the regression function over a convex class of functions. Our simulation study shows that INN outperforms common weighted nearest neighbors classifiers that only use complete training samples or modalities that are available in each sample. It performs better than methods that impute the missing data as well, even for the case where some modalities are missing not at random. The effectiveness of INN has been also demonstrated by our theoretical studies and a real application from the Alzheimer\'s disease neuroimaging initiative.

The biomarker networks measured by different modalities of data (e.g., structural magnetic resonance imaging (sMRI), diffusion tensor imaging (DTI)) may share the same true underlying biological model. In this work, we propose a node-wise biomarker graphical model to leverage the shared mechanism between multi-modality data to provide a more reliable estimation of the target modality network and account for the heterogeneity in networks due to differences between subjects and networks of external modality. Latent variables are introduced to represent the shared unobserved biological network and the information from the external modality is incorporated to model the distribution of the underlying biological network. We propose an efficient approximation to the posterior expectation of the latent variables that reduces computational cost by at least 50%. The performance of the proposed method is demonstrated by extensive simulation studies and an application to construct gray matter brain atrophy network of Huntington\'s disease by using sMRI data and DTI data. The identified network connections are more consistent with clinical literature and better improve prediction in follow-up clinical outcomes and separate subjects into clinically meaningful subgroups with different prognosis than alternative methods.

Fusing multi-modality data is crucial for accurate identification of brain disorder as different modalities can provide complementary perspectives of complex neurodegenerative disease. However, there are at least four common issues associated with the existing fusion methods. First, many existing fusion methods simply concatenate features from each modality without considering the correlations among different modalities. Second, most existing methods often make prediction based on a single classifier, which might not be able to address the heterogeneity of the Alzheimer\'s disease (AD) progression. Third, many existing methods often employ feature selection (or reduction) and classifier training in two independent steps, without considering the fact that the two pipelined steps are highly related to each other. Forth, there are missing neuroimaging data for some of the participants (e.g., missing PET data), due to the participants\' \"no-show\" or dropout. In this paper, to address the above issues, we propose an early AD diagnosis framework via novel multi-modality latent space inducing ensemble SVM classifier. Specifically, we first project the neuroimaging data from different modalities into a latent space, and then map the learned latent representations into the label space to learn multiple diversified classifiers. Finally, we obtain the more reliable classification results by using an ensemble strategy. More importantly, we present a Complete Multi-modality Latent Space (CMLS) learning model for complete multi-modality data and also an Incomplete Multi-modality Latent Space (IMLS) learning model for incomplete multi-modality data. Extensive experiments using the Alzheimer\'s Disease Neuroimaging Initiative (ADNI) dataset have demonstrated that our proposed models outperform other state-of-the-art methods.