背景:粘膜纤毛清除系统是预防鼻和鼻旁窦慢性炎症的重要组成部分。
目的:该研究旨在建立本地区粘膜纤毛清除的正常值,并研究伊洛林慢性鼻-鼻窦炎患者粘膜纤毛活动的变化,尼日利亚中北部。
方法:这是一个前瞻性的,使用对照组和研究组中连续同意的参与者在家庭医学和耳鼻喉科诊所进行的横断面研究。
方法:在寻求伦理批准后,获得患者的知情同意书,填写了经过验证的健康问卷的修改版本,还填写了半结构化问卷,之后患者接受前鼻镜检查,进行鼻腔通畅测试和肺活量测定。过去,糖精测试已用于测量鼻粘膜纤毛清除时间。
方法:将所有信息输入SPSS版本20,并进行描述性分析,结果在表格和数字中显示。
结果:对125例鼻窦炎患者(研究组)和无鼻窦炎患者(对照组)进行鼻-黏膜纤毛清除试验。研究组有34名男性和91名女性,男女比例为1:2.6,对照组有55名男性和70名女性,男女比例为1:1.3。年龄范围为18至68岁,其中18-40岁构成模态年龄组。研究组的平均年龄为35.7岁,而对照组的平均年龄为33.1岁。研究组平均鼻黏膜纤毛清除时间为35.1min标准差(SD=12.32±1.63),而在对照组中,时间为14.8min(SD=5.59±0.43)。
结论:与对照组相比,鼻窦炎患者的鼻黏膜纤毛清除时间延长约200%.与年龄增长也呈正相关。比较鼻窦炎术前和术后治疗的未来研究将有助于知识。
BACKGROUND: The mucociliary clearance system is an important component in the prevention of chronic inflammation of the nasal and paranasal sinus.
OBJECTIVE: The study aims to establish the normal values of mucociliary clearance in our region and to study the variation in mucociliary activity in patients with chronic rhinosinusitis in Ilorin, North-central Nigeria.
METHODS: This was a prospective, cross-sectional study using consecutive consenting participants in both the control and study groups carried out at both family medicine and otorhinolaryngology clinics among patients attending the clinics.
METHODS: After ethical approval was sought, informed consent was obtained from patients, a modified version of the validated health questionnaire was filled, semi-structured questionnaires were also filled after which patient undergo anterior rhinoscopy, nasal patency test and spirometry was done. The saccharine test has been used to measure nasal-mucociliary clearance time in the past.
METHODS: All information were entered into SPSS version 20 and analysed descriptively, and results were presented in tables and figures.
RESULTS: Consecutive consenting 125 patients with rhinosinusitis (study group) and those without rhinosinusitis (control group) underwent naso-mucociliary clearance test. There were 34 males and 91 females with a male:female ratio of 1:2.6 among the study group and 55 males and 70 females with a male:female ratio of 1:1.3 for the control group. The age range was from 18 to 68 years with 18-40 years constituting the modal age group. The mean age for the studied group was 35.7 years while that of the control group was 33.1 years. The mean naso-mucociliary clearance time among the study group was 35.1 min standard deviation (SD = 12.32 ± 1.63), while among the control group, it was 14.8 min (SD = 5.59 ± 0.43).
CONCLUSIONS: Compared to the control group, there was a roughly 200% prolonged increase in the duration of naso-mucociliary clearance time among patients with rhinosinusitis. There was also a positive correlation with increasing age. Future studies comparing the pre-operative and post-operative treatment of rhinosinusitis will contribute to knowledge.