■多发性硬化症(MS)是一种中枢神经系统的慢性炎症和神经退行性疾病,其特征是广泛且不可预测的症状,包括认知和社会认知功能障碍。在这些社会认知功能中,道德判断已经在MS(PwMS)患者中使用道德困境进行了探索,参与者必须决定是否牺牲一个人来拯救更多的人。选择这样的牺牲反映了功利主义的推理(为了许多人的利益而牺牲一个被认为是可以接受的),而拒绝反映道义推理(这种牺牲被认为在道德上是错误的)。与对照组相比,PwMS已被证明在这种困境中做出了更大的道义道德选择。
■虽然与对照相比,PwMS在道德困境中表现出更高的道德选择倾向,这种推理模式的潜在决定因素仍不清楚。在这个项目中,我们的目标是研究认知,情感,以及可以解释MS道义决策的动机因素。
■我们将招募45名PwMS和45名18-55岁对照的样本。响应的类型,道义或功利主义,一系列20个关于道德困境的小插曲将构成主要结果。全球认知表现,积极偏见,在道德困境期间,述情障碍和同理心水平以及通过皮肤电活动(EDA)测量的情绪反应将是次要结果。
■道德批准由国家道德委员会批准(CPPOuestIII,国号2023-A00447-38)。该项目由ARSEP基金会赞助。调查结果将在国家和国际会议上提交,以及发表在同行评审的科学期刊上。
UNASSIGNED: Multiple sclerosis (MS) is a chronic inflammatory and neurodegenerative disease of the central nervous system characterized by a broad and unpredictable range of symptoms, including cognitive and sociocognitive dysfunction. Among these social-cognitive functions, moral judgment has been explored in persons with MS (PwMS) using moral dilemmas, where participants must decide whether to sacrifice one person to save a greater number. Opting for such a sacrifice reflects utilitarian reasoning (sacrificing one for the benefit of many is deemed acceptable), while refusing reflects deontological reasoning (such sacrifice is considered morally wrong). Compared to controls, PwMS have been shown to make greater deontological moral choices in such dilemmas.
UNASSIGNED: While PwMS have demonstrated a higher tendency for deontological moral choices in moral dilemmas compared to controls, the underlying determinants of this reasoning pattern remain unclear. In this project, we aim to investigate cognitive, emotional, and motivational factors that may explain deontological decision-making in MS.
UNASSIGNED: We will recruit a sample of 45 PwMS and 45 controls aged 18-55 years. The type of response, deontological or utilitarian, to a series of 20 vignettes of moral dilemmas will constitute the primary outcomes. Global cognitive performance, positivity bias, alexithymia and empathy levels as well as emotional reactivity measured by electrodermal activity (EDA) during moral dilemmas will be secondary outcomes.
UNASSIGNED: Ethics approval was granted by a national ethical committee (CPP Ouest III, national number 2023-A00447-38). The project is sponsored by the ARSEP Foundation. Findings will be presented at national and international conferences, as well as published in peer-reviewed scientific journals.