人类接触邻苯二甲酸盐通过多种来源和途径发生。在2007-2009年加拿大健康措施调查中,11种邻苯二甲酸酯代谢物,即,MMP,MEP,MnBP,MBzP,MCHP,MCPP,MEHP,MEOHP,MEHHP,MnOP,在6-49岁调查对象的尿液样本中测量了MiNP(n=3236)。此处提供了来自加拿大全国代表性调查的邻苯二甲酸酯代谢物生物监测数据。代谢物MEP,MnBP,MBzP,MCPP,MEHP,MEOHP和MEHHP在>90%的加拿大人中检测到,而MMP,MCHP,在<20%的加拿大人口中检测到MnOP和MiNP。进行了逐步回归分析,以确定普通人群中代谢物体积浓度(μg/L)的重要预测因子。具有协变量年龄的个体多元回归模型,性别,肌酐,空腹状态,和相互作用术语年龄×肌酐,年龄×性别和空腹状态×肌酐构建为MEP,MnBP,MBzP,MCPP,MEHP,MEOHP和MEHHP。从各自的回归模型得出的代谢物的体积浓度(μg/L)的最小二乘几何平均值(LSGM)估计值用于评估群体子组中代谢物浓度的模式。结果表明,儿童尿MnBP浓度明显较高,MBzP,MEHP,MEHHP,MEOHP和MCPP高于青少年和成年人。此外,MEP,MBzP,女性的MnBP和MEOHP浓度明显高于男性。我们观察到空腹状态显着影响MEHP的浓度,MEHHP,MEOHP,和本研究中分析的MCPP代谢物。此外,我们的结果表明,采样时间可能会影响加拿大普通人群中DEHP代谢物的浓度。
Human exposure to phthalates occurs through multiple sources and pathways. In the Canadian Health Measures Survey 2007-2009, 11 phthalate metabolites, namely, MMP, MEP, MnBP, MBzP, MCHP, MCPP, MEHP, MEOHP, MEHHP, MnOP, and MiNP were measured in urine samples of 6-49 year old survey respondents (n=3236). The phthalate metabolites biomonitoring data from this nationally-representative Canadian survey are presented here. The metabolites MEP, MnBP, MBzP, MCPP, MEHP, MEOHP and MEHHP were detected in >90% of Canadians while MMP, MCHP, MnOP and MiNP were detected in <20% of the Canadian population. Step-wise regression analyses were carried out to identify important predictors of volumetric concentrations (μg/L) of the metabolites in the general population. Individual multiple regression models with covariates age, sex, creatinine, fasting status, and the interaction terms age×creatinine, age×sex and fasting status×creatinine were constructed for MEP, MnBP, MBzP, MCPP, MEHP, MEOHP and MEHHP. The least square geometric mean (LSGM) estimates for volumetric concentration (μg/L) of the metabolites derived from respective regression models were used to assess the patterns in the metabolite concentrations among population sub-groups. The results indicate that children had significantly higher urinary concentrations of MnBP, MBzP, MEHP, MEHHP, MEOHP and MCPP than adolescents and adults. Moreover, MEP, MBzP, MnBP and MEOHP concentrations in females were significantly higher than in males. We observed that fasting status significantly affects the concentrations of MEHP, MEHHP, MEOHP, and MCPP metabolites analyzed in this study. Moreover, our results indicate that the sampling time could affect the DEHP metabolite concentrations in the general Canadian population.