膜活性分子机器代表了最近出现的,然而,在人工跨膜转运蛋白领域的重要扩展线。他们迄今为止表现出有限的类型(分子摆动,离子渔民,穿梭机,转子,等。)当然需要新的鼓舞人心的发展。这里,我们报告了第一个电动离子运输载体型运输机,即,一个模块化可调的,来自Feringa的分子马达的光动力螺旋桨状转运蛋白,可在连续紫外线照射下持续促进跨膜离子运输。根据EC50值,在紫外线照射300s下,分子螺旋桨介导的离子传输活性分别是未照射Li的2.31、1.74、2.29、2.80和2.92倍,Na+,K+,Rb+,和Cs+离子,分别,光照射下K+离子的EC50值低至0.71mol%。
Membrane-active molecular machines represent a recently emerging, yet important line of expansion in the field of artificial transmembrane transporters. Their hitherto demonstrated limited types (molecular swing, ion fishers, shuttlers, rotors, etc.) certainly call for new inspiring developments. Here, we report a very first motorized ion-transporting carrier-type transporter, i.e., a modularly tunable, light-powered propeller-like transporter derived from Feringa\'s molecular motor for consistently boosting transmembrane ion transport under continuous UV light irradiation. Based on the EC50 values, the molecular propeller-mediated ion transport activities under UV light irradiation for 300 s are 2.31, 1.74, 2.29, 2.80, and 2.92 times those values obtained without irradiation for Li+, Na+, K+, Rb+, and Cs+ ions, respectively, with EC50 value as low as 0.71 mol % for K+ ion under light irradiation.