Mitral valve insufficiency

二尖瓣关闭不全
  • 文章类型: Case Reports
    尽管这是一种罕见的现象,心包包虫囊肿提出了独特的诊断挑战,需要多模态成像和多学科方法进行治疗。作者在这里介绍了一例中年男子,他被转介给他们以治疗新发的房扑伴二尖瓣反流。
    Despite being a rare phenomenon, pericardial hydatid cysts present unique diagnostic challenges and require a multimodality imaging as well as a multidisciplinary approach for a curative management. The authors here present a case of a middle aged man who was referred to them for management of new onset atrial flutter with mitral regurgitation.
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  • 文章类型: Journal Article
    对于严重的继发性二尖瓣反流伴症状性心力衰竭且射血分数降低的患者,应考虑经导管二尖瓣修复术,以改善症状和生存获益。相对于左心室扩张程度,继发性二尖瓣返流严重程度较高的患者更有可能从经导管二尖瓣修复术中受益。多学科心脏团队应参与经导管二尖瓣治疗的患者选择。
    Transcatheter mitral valve repair should be considered for patients with severe secondary mitral regurgitation with symptomatic heart failure with reduced ejection fraction for symptom improvement and survival benefit. Patients with a higher severity of secondary mitral regurgitation relative to the degree of left ventricular dilation are more likely to benefit from transcatheter mitral valve repair. A multidisciplinary Heart Team should participate in patient selection for transcatheter mitral valve therapy.
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  • 文章类型: Case Reports
    由于解剖异常和有限的暴露,漏斗胸在心脏手术中面临挑战。我们报告了一例58岁的男性,患有严重的漏斗胸和严重的二尖瓣反流,成功地通过微创二尖瓣修复术治疗。术前影像学显示心脏向左位移,哈勒指数为3.8。手术干预涉及心房回缩和瓣膜修复技术的适应。术后结果良好,二尖瓣功能正常,住院时间短。尽管技术挑战,微创方法对漏斗胸患者有好处。该病例强调了广泛漏斗胸患者微创手术的可行性和安全性,强调其作为首选方法的潜力。
    Pectus excavatum presents challenges in cardiac operations due to anatomical abnormalities and limited exposure. We report a case of a 58-year-old male with severe pectus excavatum and significant mitral regurgitation successfully treated with minimally invasive mitral valve repair. Preoperative imaging revealed leftward heart displacement and a Haller index of 3.8. Surgical intervention involved adaptations in atrial retraction and valve repair technique. Postoperative outcomes were favourable, with normal mitral function and a short hospital stay. Despite technical challenges, minimally invasive approaches offer benefits in pectus excavatum patients. This case underscores the feasibility and safety of minimally invasive surgery in patients with extensive pectus excavatum, emphasizing its potential as a preferred approach.
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  • 文章类型: Journal Article
    背景:发生心源性休克的Takotsubo综合征(TTS)患者可能出现左心室流出道梗阻(LVOTO)。在先前的研究中尚未定义该人群的预后和治疗。本研究的目的是描述临床表现,管理,根据是否存在LVOTO,TTS和心源性休克患者亚组的演变和预后。
    方法:我们在多中心注册中分析了2003年至2022年招募的TTS患者。选择患者是否在入院期间出现心源性休克。根据LVOTO的存在或不存在比较该分析。
    结果:包括322例患者,其中58人(18%)有LVOTO。大多数患者接受血管活性和正性肌力疗法(VIT)治疗,其使用与LVOTO密切相关(77.6%vs57.6%,p<0.001)。在接受VIT治疗的LVOTO组中,只有五名(3.3%)没有LVOTO的患者和两名(4.4%)的患者出现或恶化了梗阻。此外,LVOTO患者的院内并发症较高,包括室性心律失常(15.5%vs8.7%,p=0.017),大出血(13.8%vs6.1%,p=0.042)和急性肾衰竭(48.3%vs28.4%,p=0.003)。然而,在90天和5年,全因死亡的累积发生率在有和没有LVOTO的患者之间没有显着差异(HR1.20,95%CI0.60至2.40,持续90天,和5年HR1.69,95%CI0.89至3.21)。
    结论:LVOTO在TTS和心源性休克患者中并不少见。它与更积极的住院过程有关,我们的数据无法排除LVOTO的存在与TTS患者的长期预后之间的关联。与正性肌力或血管活性支持直接相关的LVOTO的发展或恶化较低。
    BACKGROUND: Patients with Takotsubo syndrome (TTS) who develop cardiogenic shock may present with left ventricular outflow tract obstruction (LVOTO). The prognosis and treatment of this population have not been defined in previous studies. The aim of this study is to describe the clinical presentation, management, evolution and prognosis of a subgroup of patients with TTS and cardiogenic shock according to whether they present with LVOTO or not.
    METHODS: We analysed patients with TTS recruited from 2003 to 2022 in a multicentre registry. Patients were selected if they presented cardiogenic shock during their admission. This analysis was compared according to the presence or absence of LVOTO.
    RESULTS: 322 patients were included, 58 (18%) of whom had LVOTO. The majority were treated with vasoactive and inotropic therapy (VIT) and its use was strongly associated with having LVOTO (77.6% vs 57.6%, p<0.001). Only five (3.3%) patients without LVOTO and two (4.4%) in the LVOTO group treated with VIT developed or worsened the obstruction. Furthermore, patients with LVOTO presented higher in-hospital complications including ventricular arrhythmias (15.5% vs 8.7%, p=0.017), major bleeding (13.8% vs 6.1%, p=0.042) and acute kidney failure (48.3% vs 28.4%, p=0.003). However, at both 90 days and 5 years, the cumulative incidence of all-cause death was not significantly different between the patients with and without LVOTO (HR 1.20, 95% CI 0.60 to 2.40 for 90 days, and HR 1.69, 95% CI 0.89 to 3.21 for 5 years).
    CONCLUSIONS: LVOTO is not uncommon in patients with TTS and cardiogenic shock. It is associated with a more aggressive in-hospital course and our data is unable to rule out an association between the presence of LVOTO and long-term prognosis of patients with TTS. The development or worsening of LVOTO directly related to inotropic or vasoactive support was low.
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  • 文章类型: Journal Article
    背景:三尖瓣反流(TR)与经导管主动脉瓣置换术(TAVR)和经导管二尖瓣边缘到边缘修复(M-TEER)后较差的临床结果相关,但对其与健康状况结果的关联知之甚少。
    目的:本研究的目的是探索,使用胸外科医师协会和美国心脏病学会TVT(经导管瓣膜治疗)注册,评估基线TR与TAVR和M-TEER术后健康状况之间的关联,并确定基线TR是否与临床终点相关.
    方法:在2019年1月至2021年6月期间接受TVT注册的患者中,使用堪萨斯城心肌病问卷总体总结(KCCQ-OS)评分评估健康状况。基线TR和KCCQ-OS评分之间的关联,活得很好,并检查临床结局.
    结果:总计,130,097名TAVR患者(13.1%患有中度TR,2.3%患有严重TR)和19,593M-TEER患者(33.2%患有中度TR,包括14.7%的严重TR)。在TAVR(39.4±24.2vs45.2±24.7vs51.3±25.3;P<0.01)或M-TEER(38.1±23.9vs41.9±24.7vs45.4±25.2;P<0.01)之前,基线时的平均KCCQ-OS评分较低,重度和中度,无轻度TR,30天和1年时相似。在TAVR之前,中度或重度TR患者在1年存活和健康的几率较低(调整后OR:0.79[95%CI:0.74-0.85]和调整后OR:0.81[95%CI:0.70-0.94],分别)和M-TEER之前的重度TR(调整后OR:0.53;95%CI:0.40-0.71)。此外,TAVR之前的中度或重度TR与较高的1年死亡率和再入院相关,而M-TEER之前的中度或重度TR与较高的1年死亡率相关.
    结论:在大量接受TAVR或M-TEER的美国患者中,较高的基线TR与较差的健康状况和临床结局相关.了解并发瓣膜异常患者的TR不良结局很重要,特别是快速发展的经导管三尖瓣介入治疗。
    BACKGROUND: Tricuspid regurgitation (TR) is associated with worse clinical outcomes after transcatheter aortic valve replacement (TAVR) and mitral transcatheter edge-to-edge repair (M-TEER), but little is known about its association with health status outcomes.
    OBJECTIVE: The aims of this study were to explore, using the Society of Thoracic Surgeons and American College of Cardiology TVT (Transcatheter Valve Therapy) Registry, the association between baseline TR and health status after TAVR and M-TEER and to determine if baseline TR was associated with clinical endpoints.
    METHODS: Health status was assessed using Kansas City Cardiomyopathy Questionnaire overall summary (KCCQ-OS) score in patients enrolled in the TVT Registry who underwent isolated TAVR or M-TEER between January 2019 and June 2021. The association among baseline TR and KCCQ-OS score, being alive and well, and clinical outcomes was examined.
    RESULTS: In total, 130,097 TAVR patients (13.1% with moderate TR, 2.3% with severe TR) and 19,593 M-TEER patients (33.2% with moderate TR, 14.7% with severe TR) were included. Mean KCCQ-OS scores were lower with severe vs moderate vs none to mild TR at baseline prior to TAVR (39.4 ± 24.2 vs 45.2 ± 24.7 vs 51.3 ± 25.3; P < 0.01) or M-TEER (38.1 ± 23.9 vs 41.9 ± 24.7 vs 45.4 ± 25.2; P < 0.01) and similarly at 30 days and 1 year. The odds of being alive and well at 1 year were lower with moderate or severe TR before TAVR (adjusted OR: 0.79 [95% CI: 0.74-0.85] and adjusted OR: 0.81 [95% CI: 0.70-0.94], respectively) and severe TR before M-TEER (adjusted OR: 0.53; 95% CI: 0.40-0.71). Furthermore, moderate or severe TR before TAVR was associated with higher 1-year mortality and readmission, whereas moderate or severe TR before M-TEER was associated with higher 1-year mortality.
    CONCLUSIONS: In a large cohort of U.S. patients who underwent TAVR or M-TEER, greater baseline TR was associated with worse health status and clinical outcomes. Understanding adverse outcomes of TR in patients with coexisting valvular abnormalities is important, especially with rapidly evolving transcatheter tricuspid valve interventions.
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  • 文章类型: Journal Article
    目的:二尖瓣反流(MR)对无症状患者的影响尚不明确。我们的目的是在一个大型未选择的无症状MR队列中确定MR相关并发症的患病率及其与10年生存率的关系。
    方法:来自德国第二大健康保险基金的健康保险索赔数据,BARMER,它维护着870万德国居民的纵向数据,进行回顾性分析。纳入所有在一个日历年中至少有两个季度的门诊诊断为MR的患者,并在2008年至2011年之间首次记录诊断。排除因MR或二尖瓣介入而出现任何并发症的患者。比较研究组与年龄和性别匹配的对照组之间的结果(即,没有已知的心脏病)。感兴趣的MR相关并发症是新的充血性心力衰竭,新发心房颤动,肺动脉高压,或者心脏代偿失调.
    结果:共有56,577人(中位年龄68岁,67%的女性)患有无症状的MR。十年后,与MR相关的并发症在研究组中更为常见。对照组(46.5%vs.20.8%,OR3.31,P<0.0001)。此外,MR相关并发症在男性和男性中更常见。女性患者无症状MR(OR2.65,P<0.0001)。至少1例MR相关并发症的发生与10年生存率降低相关(OR1.80,P<0.0001)。
    结论:几乎一半的无症状MR患者在10年的随访期间会出现并发症,导致生存受损。这些结果暗示了长期疾病管理计划的必要性。此外,应重新评估无症状患者二尖瓣介入治疗的决策过程和时机.
    OBJECTIVE: The impact of mitral regurgitation (MR) in asymptomatic patients is not well defined. We aimed to determine the prevalence of MR-related complications and their association with 10-year survival in a large unselected asymptomatic MR cohort.
    METHODS: Health insurance claims data from Germany\'s second largest health insurance fund, BARMER, which maintains longitudinal data on 8.7 million German residents, were retrospectively analyzed. All patients with an outpatient diagnosis of MR in a minimum of two quarters during a calendar year and first recorded diagnosis between 2008 and 2011 were included. Patients with any complication attributable to MR or mitral valve intervention at index were excluded. Outcomes were compared between study group and age- and sex-matched controls (i.e., without known cardiac disease). MR-related complications of interest were new congestive heart failure, new-onset atrial fibrillation, pulmonary hypertension, or cardiac decompensation.
    RESULTS: A total of 56,577 individuals (median age 68 years, 67% female) with asymptomatic MR were identified. At 10 years, MR-related complications were more frequent in the study group vs. control group (46.5% vs. 20.8%, OR 3.31, P < 0.0001). Furthermore, MR-related complications were more common in male vs. female patients with an asymptomatic MR (OR 2.65, P < 0.0001). The occurrence of at least one MR-related complication was associated with a reduced 10-year survival (OR 1.80, P < 0.0001).
    CONCLUSIONS: Almost half of patients with asymptomatic MR experience complications during a 10 year follow-up which result in impaired survival. These results imply the necessity of long-term disease management program. Furthermore, decision-making process and timing for mitral valve intervention in asymptomatic patients should be reevaluated.
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  • 文章类型: Journal Article
    二尖瓣成形术(MVP)是用于治疗狗的严重二尖瓣返流的外科手术。虽然MVP被认为是高度侵入性的,心肌损伤的程度,术后并发症,和恢复尚未评估。
    这项研究检查了MVP侵袭的程度,心肌损伤的程度,术后并发症,心肌细胞恢复,和出院时间。
    心脏肌钙蛋白I(cTnI)用于研究13例MVP患者和5例接受类似麻醉和开胸手术的动脉导管未闭(PDA)患者的心脏骤停引起的心肌损伤。
    cTnI水平在手术后1天达到峰值,并且在MVP组中明显更高(中位数,19.90ng/ml)比对照组(中位数,1.50ng/mlp<0.001)。在第7天,MVP组的cTnI水平(1.9ng/ml)明显高于对照组(0.1ng/ml)(p<0.001),MVP组恢复到术前水平需要10天,但对照组在第7天恢复到术前水平。尽管使用时体外循环(CPB)的平均动脉压为42.92mmHg,2例表现为暂时性下降20mmHg(46.03ng/ml)的患者的cTnI峰值水平显著高于其他11例患者(19.70ng/ml)(p<0.05).术前cTnI水平与术后并发症严重程度相关(P=0.03,F=0.71)。
    结果显示,MVP造成的心肌组织损伤比开胸手术更大,但术后恢复较顺利。术前较高的cTnI水平需要相对更仔细的术后管理,术后随时间测量cTnI水平可以提供有关心肌损伤程度和手术恢复的信息,并有助于确定出院时间。
    UNASSIGNED: Mitral valvuloplasty (MVP) is a surgical procedure for treating severe mitral regurgitation in dogs. Although MVP is considered highly invasive, the extent of myocardial injury, postoperative complications, and recovery has not been evaluated.
    UNASSIGNED: This study examined the degree of MVP invasiveness, the extent of myocardial damage, postoperative complications, cardiomyocyte recovery, and timing of hospital discharge.
    UNASSIGNED: Cardiac troponin I (cTnI) was used to investigate the myocardial damage caused by cardiac arrest associated with a surgical approach to the myocardium in 13 patients with MVP and five controls with patent ductus arteriosus (PDA) who underwent similar anesthesia and thoracotomy.
    UNASSIGNED: The level of cTnI peaked 1 day after surgery and was significantly higher in the MVP group (median, 19.90 ng/ml) than in the control group (median, 1.50 ng/ml p < 0.001). At day 7, the cTnI level was significantly higher in the MVP group (1.9 ng/ml) than in the control group (0.1 ng/ml) (p < 0.001), and recovery to the preoperative level took 10 days in the MVP group but returned to the preoperative level at day 7 in the control group. Although the mean arterial pressure of cardiopulmonary bypass (CPB) at the time of use was 42.92 mmHg, the peak cTnI levels in the two patients who exhibited a temporary decrease of 20 mmHg or less (46.03 ng/ml) were significantly higher than in the other 11 patients (19.70 ng/ml) (p < 0.05). Preoperative cTnI levels were correlated with the severity of postoperative complications (P = 0.03, F = 0.71).
    UNASSIGNED: The results showed that MVP caused temporary greater myocardial tissue damage than thoracotomy, but postoperative recovery was smoother. A high preoperative cTnI level requires relatively more careful postoperative management, and measuring the level of cTnI over time after surgery can provide information about the extent of myocardial damage and recovery from surgery and help determine the time of discharge.
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  • 文章类型: Journal Article
    背景:在中国,二尖瓣反流(MR)是最常见的心血管瓣膜疾病。然而,在中国,这种情况的发生率很高,再加上健康知识水平低和手术治疗率相对较低。TikTok拥有大量与疾病和健康知识相关的内容,为观众提供相关信息的访问。然而,尚未对专门针对MR的视频质量进行调查或评估。
    目的:本研究旨在评估中国TikTokMR视频的质量。
    方法:对2023年9月9日的中文版TikTok进行了横断面研究。纳入了MR的前100个视频,并使用定量评分工具进行了评估,例如改良的DISCERN(mDISCERN),美国医学会杂志(JAMA)基准标准,全球质量评分(GQS),和视听内容的患者教育材料评估工具(PEMAT-A/V)。进行了相关和逐步回归分析,以检查视频质量与各种特征之间的关系。
    结果:我们获得了88个有效的视频文件,其中大部分(n=81,92%)是由认证医生上传的,主要是心脏外科医生,和心脏病学家。与个人相比,新闻机构/组织和医生的GQS得分更高(新闻机构/组织与个人,P=.001;医生与个人之间,P=.03)。此外,新闻机构/组织的PEMAT可理解性得分高于个人(P=0.01)。关注疾病知识的视频在GQS中得分更高(P<.001),PEMAT可理解性(P<.001),与涵盖手术病例的视频相比,PEMAT可操作性(P<.001)。与手术病例相比,门诊病例的PEMAT可操作性评分更高(P<0.001)。此外,聚焦于外科技术的视频的PEMAT可操作性评分低于关于疾病知识的视频(P=.04).观察到的最强相关性是竖起大拇指和评论(r=0.92,P<.001),竖起大拇指和收藏夹(r=0.89,P<.001),竖起大拇指并分享(r=0.87,P<.001),评论和收藏夹(r=0.81,P<.001),评论和分享(r=0.87,P<.001),以及收藏夹和股票(r=0.83,P<.001)。逐步回归分析确定长度(P<.001),\"\"内容(P<.001),“和”医生(P=0.004)“是GQS的重要预测因子。最终模型(模型3)解释了GQSs中50.1%的方差。GQS的预测方程如下:GQS=3.230-0.294×含量-0.274×医师0.005×长度。该模型具有统计学意义(P=.004),并且没有显示出多重共线性或自相关的问题。
    结论:我们的研究表明,尽管TikTok上大多数与MR相关的视频都是由认证医师上传的,确保专业和科学的内容,总体质量评分不理想.尽管这些视频具有教育价值,提供的指导往往是不够的。从我们的分析中得出的GQS预测方程提供了有价值的见解,但应在研究范围之外谨慎应用。它建议创作者应专注于改善视频的内容和呈现方式,以提高在社交媒体上共享的健康信息的质量。
    BACKGROUND: In China, mitral valve regurgitation (MR) is the most common cardiovascular valve disease. However, patients in China typically experience a high incidence of this condition, coupled with a low level of health knowledge and a relatively low rate of surgical treatment. TikTok hosts a vast amount of content related to diseases and health knowledge, providing viewers with access to relevant information. However, there has been no investigation or evaluation of the quality of videos specifically addressing MR.
    OBJECTIVE: This study aims to assess the quality of videos about MR on TikTok in China.
    METHODS: A cross-sectional study was conducted on the Chinese version of TikTok on September 9, 2023. The top 100 videos on MR were included and evaluated using quantitative scoring tools such as the modified DISCERN (mDISCERN), the Journal of the American Medical Association (JAMA) benchmark criteria, the Global Quality Score (GQS), and the Patient Education Materials Assessment Tool for Audio-Visual Content (PEMAT-A/V). Correlation and stepwise regression analyses were performed to examine the relationships between video quality and various characteristics.
    RESULTS: We obtained 88 valid video files, of which most (n=81, 92%) were uploaded by certified physicians, primarily cardiac surgeons, and cardiologists. News agencies/organizations and physicians had higher GQS scores compared with individuals (news agencies/organizations vs individuals, P=.001; physicians vs individuals, P=.03). Additionally, news agencies/organizations had higher PEMAT understandability scores than individuals (P=.01). Videos focused on disease knowledge scored higher in GQS (P<.001), PEMAT understandability (P<.001), and PEMAT actionability (P<.001) compared with videos covering surgical cases. PEMAT actionability scores were higher for outpatient cases compared with surgical cases (P<.001). Additionally, videos focused on surgical techniques had lower PEMAT actionability scores than those about disease knowledge (P=.04). The strongest correlations observed were between thumbs up and comments (r=0.92, P<.001), thumbs up and favorites (r=0.89, P<.001), thumbs up and shares (r=0.87, P<.001), comments and favorites (r=0.81, P<.001), comments and shares (r=0.87, P<.001), and favorites and shares (r=0.83, P<.001). Stepwise regression analysis identified \"length (P<.001),\" \"content (P<.001),\" and \"physicians (P=.004)\" as significant predictors of GQS. The final model (model 3) explained 50.1% of the variance in GQSs. The predictive equation for GQS is as follows: GQS = 3.230 - 0.294 × content - 0.274 × physicians + 0.005 × length. This model was statistically significant (P=.004) and showed no issues with multicollinearity or autocorrelation.
    CONCLUSIONS: Our study reveals that while most MR-related videos on TikTok were uploaded by certified physicians, ensuring professional and scientific content, the overall quality scores were suboptimal. Despite the educational value of these videos, the guidance provided was often insufficient. The predictive equation for GQS developed from our analysis offers valuable insights but should be applied with caution beyond the study context. It suggests that creators should focus on improving both the content and presentation of their videos to enhance the quality of health information shared on social media.
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  • 文章类型: Case Reports
    一名76岁的女性,具有复杂的病史,在二尖瓣导管边缘到边缘修复(TEER)2个月后接受Watchman(波士顿科学公司)放置。Watchman放置前的术前检查证实左上肺静脉中存在血栓。术后二尖瓣TEER经食管超声心动图显示左心房附件或肺静脉无血栓。我们认为,由于二尖瓣TEER过程中的上皮损伤,左上肺静脉中的血栓是继发的。
    A 76-year-old female with a complicated medical history presented for Watchman (Boston Scientific) placement 2 months after mitral valve transcatheter edge-to-edge repair (TEER). Preoperative workup before Watchman placement confirmed the presence of a thrombus in the left superior pulmonary vein. Post-procedure mitral valve TEER transesophageal echocardiogram showed no thrombus in the left atrium appendage or pulmonary veins. We believe the thrombus in the left superior pulmonary vein occurred secondarily due to epithelium damage during the mitral valve TEER.
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  • 文章类型: Journal Article
    暂无摘要。
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