在这项研究中,聚(AVGVP)的合成[其中A-丙氨酸,V-缬氨酸,G-甘氨酸,和P-脯氨酸]通过逐步求解阶段法执行。在液相和固相中检查了壳聚糖与合成聚肽之间的相互作用。建立与壳聚糖的总混溶性的粘度标准是Δ[η]m,特性粘度[η],哈金斯系数[KH],加西亚ΔB,太阳的α,和μ由Chee建议,ΔK,β由江和汉支撑。此外,通过差示扫描量热法(DSC)在固相中证实了结果,傅里叶变换红外光谱(FTIR),扫描电子显微镜(SEM),和X射线衍射(XRD)。共混物的混溶性导致比纯聚合物更高的热稳定性,根据热重分析(TGA)。体外,研究表明没有细胞毒性,和体内组织病理学结果表明,该混合物显示出较少的炎症和更紧凑的棉规格,证明了增强的愈合环境,并有望在伤口治疗应用中使用。
In this study, the synthesis of poly(AVGVP) [where A-Alanine, V-Valine, G-Glycine, and P-Proline] is executed by the stepwise solution phase method. The interaction between Chitosan and synthetic polypentapeptide in blends was examined in the liquid and solid phases. Viscosity criteria that establish the total
miscibility with Chitosan are the Δ[η]m, the intrinsic viscosity [η], Huggins coefficient [KH], by Garcia ΔB, α by Sun, and μ suggested by Chee, ΔK, and β buttressed by Jiang and Han. Besides, the results are corroborated in the solid phase by differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and X-ray diffraction (XRD).
Miscibility in the blends led to higher thermal stability than that of pure polymers, according to thermogravimetric analysis (TGA). In vitro, studies offered the absence of cytotoxicity, and in vivo histopathological results advocated that the blend shows less inflammation and is more compact as against cotton gauge, evincing an enhanced healing environment and promising the possibility of use in wound therapeutic applications.