目的:本研究的目的是比较使用甲基睾酮的卵巢反应不良患者的体外受精(IVF)结局,与那些使用安慰剂的人相比,在不孕症诊所设置。
方法:这项临床试验包括120名由于卵巢储备力差和不孕而接受卵胞浆内单精子注射IVF的妇女。这项研究是在德黑兰的亚斯不孕不育中心进行的,伊朗,2018年1月1日至2019年1月1日。在干预组中,在开始辅助生殖治疗之前,每天给药25mg甲基睾丸激素,持续2个月。对照组在开始其周期之前给予相同持续时间的安慰剂片剂。每组随机分配60例患者。所有分析均使用SPSSver进行。23(IBM公司).
结果:干预组子宫内膜厚度为7.57±1.22mm,而在对照组中,它是7.11±1.02(p=0.028)。对照组促性腺激素数量明显高于对照组(64.7±13.48vs.57.9±9.25,p=0.001)。然而,两组的窦卵泡计数无显著差异。干预组的化学妊娠率和临床妊娠率分别为18.33%和15%,对照组分别为8.33%和6.67%。干预组的最终妊娠率稍高(13.3%vs.3.3%,p=0.05)。
结论:本研究结果表明,甲基睾酮预处理可显著增加子宫内膜厚度,并与最终妊娠率增加相关。
OBJECTIVE: The aim of this study was to compare the outcomes of in vitro fertilization (IVF) in patients with a poor ovarian response who used
methyltestosterone, versus those using a placebo, in an infertility clinic setting.
METHODS: This clinical trial included 120 women who had undergone IVF with intracytoplasmic sperm injection due to poor ovarian reserve and infertility. The study took place at the Yas Infertility Center in Tehran, Iran, between January 1, 2018 and January 1, 2019. In the intervention group, 25 mg of
methyltestosterone was administered daily for 2 months prior to the initiation of assisted reproductive treatment. The control group was given placebo tablets for the same duration before starting their cycle. Each group was randomly assigned 60 patients. All analyses were performed using SPSS ver. 23 (IBM Corp.).
RESULTS: The endometrial thickness in the intervention group was 7.57±1.22 mm, whereas in the control group, it was 7.11±1.02 (
p=0.028). The gonadotropin number was significantly higher in the control group (64.7±13.48 vs. 57.9±9.25,
p=0.001). However, there was no significant difference between the two groups in the antral follicular count. The chemical and clinical pregnancy rates in the intervention group were 18.33% and 15% respectively, compared to 8.33% and 6.67% in the control group. The rate of definitive pregnancy was marginally higher in the intervention group (13.3% vs. 3.3%, p=0.05).
CONCLUSIONS: The findings of this study suggest that pretreatment with
methyltestosterone significantly increases endometrium thickness and is associated with an increase in the definitive pregnancy rate.