主要目的是确定我们医院收治的癌症患者的死亡率,他们的临床和人口统计学特征,调查癌症患者感染COVID-19的风险,并确定影响死于COVID-19的癌症患者死亡率的因素。自3月11日起,我院共收治2401例确诊为COVID-19的患者,2020年5月31日,2020年。根据计划的纳入/排除标准,总共112名癌症患者中有92名被纳入本研究。临床,人口统计学,并研究了实验室特征和提供的治疗方法,并分析了它们对死亡率的影响。在我们的研究中,患者的中位年龄为67岁,55.4%为男性。超过一半(56.5%)的患者有转移。COVID-19患者的死亡率为6.2%,而癌症患者的死亡率为23.9%。与无转移患者相比,有转移患者的死亡率在统计学上显着较高(34.0%vs.10.3%P=0.008)。仍吸烟患者的死亡率在统计学上显着高于不吸烟者(37.5%vs.12.5%P=0.033)。高平均C反应蛋白(CRP)患者的死亡率,铁蛋白,乳酸脱氢酶(LDH),和D-二聚体水平在统计学上显著高于那些没有,平均白蛋白和血红蛋白水平较低的患者死亡率明显高于无白蛋白和血红蛋白水平较低的患者(分别为P<0.001,P=0.006,P=0.041,P<0.001,P<0.001,P=0.028)。与COVID-19同时发生转移是预测预后的统计学显著因素。此外,高CRP,铁蛋白,LDH,和D-二聚体,低白蛋白和低血红蛋白与死亡率增加有关。与预后相关的可能因素的预测和预后作用尚不清楚,需要多中心前瞻性研究来证实这些结果。
The main objective is to define the mortality of patients with cancer admitted to our hospital, their clinical and demographic characteristics, investigate the risk of COVID-19 for patients with cancer, and determine factors that affect the mortality rates of patients with cancer dying of COVID-19. A total of 2401 patients were admitted to our hospital with the diagnosis of COVID-19 from March 11th, 2020, to May 31st, 2020. Ninety-two out of a total of 112 cancer patients were included in this study based on the planned inclusion/exclusion criteria. The clinical, demographic, and laboratory features and treatments provided were studied, and their effect on mortality rates was analyzed. In our study the median age of the patients was 67 years, and 55.4% were male. More than half (56.5%) of our patients had metastasis. The mortality rate was 6.2% in the overall population with COVID-19, whereas it was 23.9% in patients with cancer. The mortality rate in patients with metastasis was statistically significantly higher compared with those without metastasis (34.0% vs. 10.3% P = 0.008). The mortality rate in patients still smoking was statistically significantly higher than in non-smokers (37.5% vs. 12.5% P = 0.033). The mortality rates of patients with high average C-reactive protein (CRP), ferritin, lactate dehydrogenase (LDH), and D-dimer levels were statistically significantly higher than in those without, and the mortality rates of patients with lower average albumin and hemoglobin levels were statistically significantly higher than those without (P < 0.001, P = 0.006, P = 0.041, P < 0.001, P < 0.001, and P = 0.028, respectively). Having metastases concurrent with COVID-19 was a statistically significant factor predictive of prognosis. Also, high CRP, ferritin, LDH, and D-dimer, and low albumin and hemoglobin were related to increased mortality rates. The predictive and prognostic role of possible factors related to prognosis is still unknown and further large, multicenter prospective studies are needed to confirm these results.