■维生素摄入量与抑郁症之间的关系引起了越来越多的关注。然而,对不同年龄组人群之间这种关系的几项研究得出的结论不一致.这项研究旨在调查美国成年人维生素K摄入量与抑郁症状之间的横断面关系。
■我们使用了2013年至2018年全国健康与营养检查调查(NHANES)的11,687名成年人的全国代表性样本数据。通过第一天的24小时饮食召回评估维生素K的摄入量。使用9项患者健康问卷(PHQ-9)评估抑郁症状。采用Logistic回归和广义加性模型研究维生素K摄入量与抑郁症状之间的关系。
抑郁症状的加权患病率为10.2%(男性为8.0%,女性为12.0%)。我们观察到维生素K摄入量与抑郁症状之间存在显著的反线性关系,性别,种族/民族,婚姻状况,教育状况,家庭贫困收入比(PIR),家庭地位,体重指数(BMI),吸烟状况,身体活动,睡眠障碍,高血压,高脂血症,和糖尿病。与维生素K摄入量最低四分位数相比,最高的比值比(OR)(95%CI)为0.68(95%CI:0.52,0.89,p趋势<0.05)。在按年龄分层的亚组中,关联相似,性别,种族/民族,婚姻状况,教育状况,PIR,家庭地位,BMI,吸烟状况,身体活动,睡眠障碍,高血压,高脂血症,和糖尿病。
■在美国成年人中,维生素K的摄入与抑郁症状的几率呈负相关,并且是独立的。有必要进行前瞻性研究以证实我们的发现。
UNASSIGNED: The relationship between vitamin intake and depression has attracted increasing attention. However, several studies examining such relationship among populations at different age groups have produced inconsistent findings. This study was aimed to investigate the cross-sectional association between vitamin K intake and depressive symptoms in US adults.
UNASSIGNED: We used the data from a nationally representative sample of 11,687 adults from the 2013 to 2018 National Health and Nutrition Examination Survey (NHANES). Vitamin K intake was assessed by the 24-h dietary recall at the first day. Depressive symptoms were assessed using the 9-item Patient Health Questionnaire (PHQ-9). Logistic regression and generalized additive model were used to examine the association between vitamin K intake and depressive symptoms.
UNASSIGNED: The weighted prevalence of depressive symptoms was 10.2% (8.0% in men and 12.0% in women). We observed a significant inverse linear relationship between vitamin K intake and depressive symptoms in models adjusted for age, sex, race/ethnicity, marital status, educational status, family poverty income ratio (PIR), home status, body mass index (BMI), smoking status, physical activity, sleep disorders, hypertension, hyperlipidemia, and diabetes. The odds ratios (OR) (95% CI) for the highest compared with the lowest quartile of vitamin K intake was 0.68 (95% CI: 0.52, 0.89, p-trend < 0.05). The association was similar in subgroups stratified by age, sex, race/ethnicity, marital status, educational status, PIR, home status, BMI, smoking status, physical activity, sleep disorders, hypertension, hyperlipidemia, and diabetes.
UNASSIGNED: Vitamin K intake was inversely and independently associated with the odds of depressive symptoms in the US adults. Prospective studies are warranted to confirm our findings.