■尽管吸烟和与健康相关的生活质量(HRQoL)对抑郁症的负面影响已在各种研究中得到证实,关于HRQoL如何介导吸烟与抑郁之间的关系的探索很少。本研究的目的是研究吸烟与尼古丁依赖的中国当前吸烟者的抑郁之间的关系以及HRQoL的中介作用。
■一项名为“中国居民心理和行为调查”的横断面研究于2021年7月10日至9月15日在中国进行。尼古丁依赖,HRQoL和抑郁通过Fagerstrom尼古丁依赖测试(FTND)测量,欧洲五维五级健康量表(EQ-5D-5L)和9项患者健康问卷(PHQ-9)。关于年龄的信息,性别,居住地,户籍,教育水平,婚姻状况,就业状况,家庭平均月收入,饮酒频率,生活状态,BMI,还收集了多种慢性疾病。进行Pearson相关检验和logistic回归分析,以探讨尼古丁依赖之间的关联。HRQoL和抑郁以及中介分析被用来探讨HRQoL在这种关系中的中介作用。
■总共1,381名当前吸烟者被纳入研究。参与者表现出中等程度的尼古丁依赖,平均为1.36(SD=1.50),HRQoL得分水平相对较高(平均值=0.94,SD=0.13),抑郁评分平均为6.48(SD=6.09)。大约22.74%(314/1,381)的参与者被认为是抑郁症。在单变量回归模型中,发现尼古丁依赖与抑郁症呈正相关(OR:1.094,95CI:1.008-1.187),而HRQoL与抑郁呈负相关(OR:0.011,95CI:0.004-0.033)。在多元回归模型中,HRQoL仍然与抑郁症显著相关(OR:0.008,95CI:0.002-0.027),然而,在尼古丁依赖和抑郁之间未观察到正相关.Pearson相关检验显示,尼古丁依赖与HRQoL呈负相关(rs=-0.147,P<0.001),HRQoL与抑郁呈负相关(rs=-0.275,P<0.001)。相比之下,尼古丁依赖与抑郁呈正相关(rs=0.136,P<0.001)。中介分析发现,HRQoL对尼古丁依赖与抑郁之间的关系起调节作用,中介效应为26.49%。
■研究结果支持尼古丁依赖与抑郁呈正相关,而HRQoL与当前吸烟者的抑郁呈负相关。HRQoL介导了尼古丁依附与抑郁的关系。旨在促进戒烟和改善生活质量的既定必要干预措施可能有助于减轻当前吸烟者的抑郁症。
UNASSIGNED: Although the negative impact of smoking and health-related quality of life (HRQoL) on depression has been confirmed in various studies, There has been little exploration of how HRQoL mediates the relationship between smoking and depression. The purpose of the current study was to examine the relationship between smoking and depression in the Chinese current smokers with nicotine dependence and the mediating role of HRQoL.
UNASSIGNED: A cross-sectional study named \"Psychology and Behavior Investigation of Chinese Residents\" was conducted from July 10 to September 15, 2021 in China. Nicotine dependence, HRQoL and depression were measured by Fagerstrom Test for Nicotine Dependence (FTND), the European Five Dimensional Five Level Health scale (EQ-5D-5L) and the 9-item Patient Health Questionnaire (PHQ-9) respectively. Information on age, gender, place of residence, household registration, education level, marital status, employment status, average family monthly income, drinking frequency, living status, BMI, multiple chronic conditions were also collected. Pearson\'s correlation test and logistic regression analysis were conducted to explore the association between nicotine dependence, HRQoL and depression and a mediation analysis was applied to explore the mediating effect of the HRQoL on this relationship.
UNASSIGNED: A total of 1,381 current smokers were included in the study. The participants showed a moderate level of nicotine dependence with a mean of 1.36(SD=1.50), a relatively high level of HRQoL scores (Mean=0.94, SD=0.13), and a depression score with a mean of 6.48(SD=6.09). Approximately 22.74% (314/1,381) of the participants were considered to indicate depression. In the univariable regression model, it was found that nicotine dependence was positively associated with depression (OR:1.094, 95%CI: 1.008-1.187), while HRQoL was negatively associated with depression (OR:0.011, 95%CI: 0.004-0.033). In the multivariable regression model, HRQoL was still notably associated with depression (OR:0.008, 95%CI: 0.002-0.027), however, the positive association was not observed between nicotine dependence and depression. The Pearson\'s correlation test demonstrated that nicotine dependence was negatively correlated with HRQoL(rs= -0.147, P<0.001) and HRQoL was negatively correlated with depression(rs= -0.275, P<0.001). In contrast, nicotine dependence was positively correlated with depression(rs= 0.136, P<0.001). Mediation analysis found that HRQoL moderated the relationship between nicotine dependence and depression with a mediating effect of 26.49%.
UNASSIGNED: The findings support that nicotine dependence is positively associated with depression and HRQoL is negatively associated with depression in current smokers. HRQoL mediated the relationship between nicotine dependence and depression. The well-established imperative interventions aimed at promoting smoking cessation and improving quality of life may benefit for alleviation of depression in current smokers.