■确定1-6岁儿童超声引导锁骨上臂丛神经阻滞(SC-BPB)的0.2%罗哌卡因的中位有效量(EV50)。
■招募在重庆医科大学儿童医院进行单侧上肢手术的美国麻醉医师协会(ASA)1至6岁的儿童。所有患者均在全麻联合臂丛神经阻滞下进行手术。麻醉诱导后超声引导SC-BPB,定位后给予0.2%罗哌卡因。在研究中,我们使用Dixon的上下方法,初始剂量为0.50ml/kg。考虑到上一块的效果,成功或失败的块可以产生0.05ml/kg的体积减少或增加,相应地。实验在有7个拐点时停止。使用等渗回归和自举算法,计算EV50,95%有效体积(EV95)和95%置信区间(CI)。患者的一般信息,术后疼痛评分,并记录不良事件.
■27名患者参与了这项研究。0.2%罗哌卡因的EV50为0.150ml/kg(95%CI,0.131-0.169ml/kg),EV95(次要指标)为0.195ml/kg(95%CI,0.188-0.197ml/kg)。研究期间未发生不良事件。
■对于1-6岁接受单侧上肢手术的儿童的超声引导SC-BPB,0.2%罗哌卡因的EV50为0.150ml/kg(95%CI,0.131~0.169ml/kg).
UNASSIGNED: To determine the median effective volume (EV50) of 0.2% ropivacaine for ultrasound-guided supraclavicular brachial plexus block (SC-BPB) in children aged 1-6 years.
UNASSIGNED: Children aged from 1 to 6 years with an American Society of Anaesthesiologists (ASA) physical status I-II who were scheduled for unilateral upper extremity surgery at the Children\'s Hospital of Chongqing Medical University were recruited. All patients underwent surgery under general anaesthesia combined with brachial plexus block. SC-BPB was guided by ultrasound after anaesthesia induction, and 0.2% ropivacaine was given after localization. In the study, we used Dixon\'s up-and-down approach with an initial dose of 0.50 ml/kg. Considering the effect of the previous block, a successful or failed block could produce a 0.05 ml/kg decrement or increment in volume, correspondingly. The experiment was stopped when there were 7 inflection points. Using isotonic regression and bootstrapping algorithms, the EV50, the 95% effective volume (EV95) and the 95% confidence interval (CI) were calculated. The patients\' general information, postoperative pain scores, and adverse events were also recorded.
UNASSIGNED: Twenty-seven patients were involved in this study. The EV50 of 0.2% ropivacaine was 0.150 ml/kg (95% CI, 0.131-0.169 ml/kg) and the EV95 (secondary metric) was 0.195 ml/kg (95% CI, 0.188-0.197 ml/kg). No adverse events occurred during the research study.
UNASSIGNED: For ultrasound-guided SC-BPB in children aged 1-6 years undergoing unilateral upper extremity surgery, the EV50 of 0.2% ropivacaine was 0.150 ml/kg (95% CI, 0.131-0.169 ml/kg).