未经证实:本研究调查了凝血酶-抗凝血酶复合物(TAT)的诊断性能,纤溶酶-α2纤溶酶抑制剂复合物(PIC),组织纤溶酶原激活物-纤溶酶原激活物抑制剂复合物(t-PAIC),和血栓调节蛋白(TM)在早期识别大面积脑梗死中的作用。
UNASSIGNED:将423例经影像学检查确诊的脑梗死患者分为大面积脑梗死(MCI)组和非大面积脑梗死(NMCI)组。TAT,PIC,t-PAIC,入院后立即测量TM。通过接收器特征工作曲线(ROC)分析诊断性能。
未经证实:TAT的血浆浓度中位数,PIC,早发性MCI患者的t-PAIC为5.10ng/ml,1.11μg/ml,和8.80ng/ml,分别,高于NMCI患者(2.20ng/ml,0.59μg/ml,和7.35ng/ml),差异有统计学意义(P<0.001)。多因素Logistic回归分析显示TAT是大面积脑梗死发生的独立危险因素(OR=1.138)。ROC曲线分析表明,PIC在早期识别MCI方面表现最佳(AUC=82.8%),当PIC浓度≥0.8μg/ml时,灵敏度为80.7%,特异性为76.2%;TAT在鉴定MCI方面具有最高的特异性,当TAT浓度≥3.97ng/ml时,特异性为80.6%。
未经评估:检测PIC,TAT,t-PAIC,和TM是血管内皮损伤和凝血和纤溶系统激活的综合评估,对MCI患者的早期识别具有诊断价值,加上它易于检测,可作为早期识别大血管闭塞的血浆标志物。
UNASSIGNED: This study investigated the diagnostic performance of the thrombin-antithrombin complex (TAT), plasmin-α2 plasmin inhibitor complex (PIC), tissue plasminogen activator-plasminogen activator inhibitor complex (t-PAIC), and thrombomodulin (TM) in the early identification of massive cerebral infarction.
UNASSIGNED: A total of 423 patients with cerebral infarction confirmed by imaging examination were divided into the massive cerebral infarction (MCI) group and the non-massive cerebral infarction (NMCI) group. TAT, PIC, t-PAIC, and TM were measured immediately after admission. The diagnostic performance was analyzed by the receiver characteristic operating curve (ROC).
UNASSIGNED: The median plasma concentrations of TAT, PIC, and t-PAIC in patients with MCI at early onset were 5.10 ng/ml, 1.11 μg/ml, and 8.80 ng/ml, respectively, which were higher than those in patients with NMCI (2.20 ng/ml, 0.59 μg/ml, and 7.35 ng/ml), and the difference was statistically significant (P < 0.001). TAT was shown to be an independent risk factor for the development of massive cerebral infarction by a multivariate logistic regression analysis (OR = 1.138). A ROC curve analysis showed that PIC had the best performance in identifying MCI at an early stage (AUC = 82.8%), with a sensitivity of 80.7% and a specificity of 76.2% when the PIC concentration was ≥0.8 μg/ml; TAT had the highest specificity in identifying MCI, with a specificity of 80.6% when the TAT concentration was ≥3.97 ng/ml.
UNASSIGNED: The detection of PIC, TAT, t-PAIC, and TM is a comprehensive assessment of vascular endothelial damage and activation of the coagulation and fibrinolytic systems and has diagnostic value for early identification of patients with MCI, which, together with its ease of detection, can be used as a plasma marker for early identification of large vessel occlusion.