■先前的研究表明,暴露于环境细颗粒物(PM2.5)可能会增加代谢综合征(MetS)的风险。然而,PM2.5化学成分的具体影响仍不确定。
■对12,846名中国中老年人进行了全国横断面研究。采用基于卫星的时空模型来确定3年平均PM2.5成分暴露量,包括硫酸盐(SO42-),硝酸盐(NO3-),氨(NH4+),黑碳(BC),有机质(OM)。使用广义线性模型来研究PM2.5成分与MetS以及MetS成分的关联,和有限的三次样条曲线用于建立PM2.5成分与MetS之间的暴露-响应关系,以及MetS的组成部分。
■PM2.5,SO4-每四分位数之间的上升,MetS风险分别增加35.1、33.5、33.6、31.2、32.4和31.4%,NO3-,NH4+,OM和BC,分别。对于MetS组件,PM2.5化学成分与评估的中心性肥胖风险相关,高血压(高血压),高空腹血糖(高FBG),和低高密度脂蛋白胆固醇(低HDL)。
■这项研究表明,暴露于PM2.5成分与MetS及其成分的风险增加有关,包括中心性肥胖,高BP,高FBG,和低HDL。此外,我们发现PM2.5化学成分对MetS的不利影响对单身人士更敏感,离婚,或者比已婚人士丧偶。
UNASSIGNED: Previous studies indicated that exposure to ambient fine particulate matter (PM2.5) could increase the risk of metabolic syndrome (MetS). However, the specific impact of PM2.5 chemical components remains uncertain.
UNASSIGNED: A national cross-sectional study of 12,846 Chinese middle-aged and older adults was conducted. Satellite-based spatiotemporal models were employed to determine the 3-year average PM2.5 components exposure, including sulfates (SO4 2-), nitrates (NO3 -), ammonia (NH4 +), black carbon (BC), and organic matter (OM). Generalized linear models were used to investigate the associations of PM2.5 components with MetS and the components of MetS, and restricted cubic splines curves were used to establish the exposure-response relationships between PM2.5 components with MetS, as well as the components of MetS.
UNASSIGNED: MetS risk increased by 35.1, 33.5, 33.6, 31.2, 32.4, and 31.4% for every inter-quartile range rise in PM2.5, SO4 2-, NO3 -, NH4 +, OM and BC, respectively. For MetS components, PM2.5 chemical components were associated with evaluated risks of central obesity, high blood pressure (high-BP), high fasting glucose (high-FBG), and low high-density lipoprotein cholesterol (low-HDL).
UNASSIGNED: This study indicated that exposure to PM2.5 components is related to increased risk of MetS and its components, including central obesity, high-BP, high-FBG, and low-HDL. Moreover, we found that the adverse effect of PM2.5 chemical components on MetS was more sensitive to people who were single, divorced, or widowed than married people.