背景:我们最近报道了从CichoriumintybusL.(CE)的地上部分制备的提取物具有保肝作用,降血脂,和低血糖特性。本文重点研究了CE对雄性大鼠生殖系统的影响以及这种治疗对妊娠和后代发育的影响。
方法:实验雄性大鼠接受100mg/kgbw/天,500毫克/千克体重/天,和1000毫克/千克体重/天的CE连续60天口服。将接受自来水的大鼠用作对照。治疗后,我们评估了CE对男性生殖系统的影响,生育力,和后代发育。
结果:对于CE治疗的雄性大鼠,有显着增加(1)直径的生精小管,(2)生精指数,(3)总精子和活动精子的数量,和(4)睾酮水平。此外,在CE治疗组中,胚胎的植入前和植入后死亡减少.从CE处理的雄性出生的所有幼崽都表现出正常的发育。
结论:CE治疗可显著改善男性生殖功能。当雄性接受CE治疗时,未观察到对妊娠和后代发育的不利影响。对CE的进一步临床评估应导致开发出安全有效的治疗男性不育的植物药物。
BACKGROUND: We recently reported that extract prepared from the aerial part of Cichorium intybus L. (CE) possesses hepatoprotective, hypolipidemic, and hypoglycemic properties. This paper focuses on the effects of CE on the male rat reproductive system and the effects of this treatment on pregnancy and offspring development.
METHODS: The experimental male rats received 100 mg/kg bw/day, 500 mg/kg bw/day, and 1000 mg/kg bw/day of CE orally for 60 consecutive days. Rats that received tap water were used as controls. After treatment, we evaluated the effects of CE on the male reproductive system, fertility, and offspring development.
RESULTS: For CE-treated male rats, there was a significant increase in the (1) diameter of seminiferous tubules, (2) spermatogenic index, (3) number of total and motile spermatozoa, and (4) testosterone levels. Additionally, there was a decrease in the pre- and post-implantation death of the embryos in the CE-treated group. All pups born from CE-treated males demonstrated normal development.
CONCLUSIONS: CE treatment significantly improved male reproductive functions. No adverse effects on pregnancy and offspring development were observed when males were treated with CE. Further clinical evaluation of CE should lead to the development of a safe and effective phytodrug for treating male infertility.