神经递质(NT)是由神经元产生的分子,充当身体的化学信使。它们在人体系统中的异常水平与许多疾病和神经退行性疾病有关,这使得对NT的监测至关重要。专门用于临床分析和了解大脑行为,同时快速可靠地检测低水平NTs对于疾病预防和早期诊断至关重要。然而,目前采用的方法通常是侵入性的或不适合于多个NT检测。在这里,我们开发了一种基于MXene的阻抗测量电子舌(e-t舌),用于敏感的NT监测,使用NB2C,Nb4C3,Mo2C,和Mo2Ti2C3MXenes作为电子舌的传感单元,和主成分分析(PCA)作为数据处理方法。高比表面积,不同的电性能,MXenes的化学稳定性使传感器阵列对NT检测具有高灵敏度和良好的重现性。具体来说,电子舌检测并区分了多种NTs(乙酰胆碱,多巴胺,甘氨酸,谷氨酸,组胺,和酪氨酸)的浓度低至1nmolL-1,并且混合物中存在定量的NT。此外,对干扰物和实际样本进行的分析证实了该系统用于临床诊断的潜力.结果表明,基于MXene的电子舌是一种合适的,快速,方法简便,具有较高的准确度和灵敏度。
Neurotransmitters (NTs) are molecules produced by neurons that act as the body\'s chemical messengers. Their abnormal levels in the human system have been associated with many disorders and neurodegenerative diseases, which makes the monitoring of NTs fundamentally important. Specifically for clinical analysis and understanding of brain behavior, simultaneous detection of NTs at low levels quickly and reliably is imperative for disease prevention and early diagnosis. However, the methods currently employed are usually invasive or inappropriate for multiple NTs detection. Herein, we developed a MXene-based impedimetric electronic tongue (e-tongue) for sensitive NT monitoring, using Nb2C, Nb4C3, Mo2C, and Mo2Ti2C3
MXenes as sensing units of the e-tongue, and Principal Component Analysis (PCA) as the data treatment method. The high specific surface area, distinct electrical properties, and chemical stability of the
MXenes gave rise to high sensitivity and good reproducibility of the sensor array toward NT detection. Specifically, the e-tongue detected and differentiated multiple NTs (acetylcholine, dopamine, glycine, glutamate, histamine, and tyrosine) at concentrations as low as 1 nmol L-1 and quantified NTs present in a mixture. Besides, analyses performed with interferents and actual samples confirmed the system\'s potential to be used in clinical diagnostics. The results demonstrate that the MXene-based e-tongue is a suitable, rapid, and simple method for NT monitoring with high accuracy and sensitivity.