未经证实:结核病(TB)是全球主要的死亡原因之一。放射学在药物敏感(DS)和利福平耐药(RR)肺结核(PTB)的诊断中都具有重要作用。这项研究旨在比较乌干达按HIV血清状态分层的微生物学证实的DS和RRPTB病例的胸部X射线(CXR)模式。
UNASSIGNED:我们在Mulago国家转诊医院(MNRH)TB病房进行了一项基于医院的回顾性研究。所有参与者都有PTB的微生物学诊断。提取的CXR发现包括浸润物,合并,空腔,纤维化,支气管扩张,肺不张,和其他非肺实质的发现。所有胶片均由两名对临床诊断不知情的独立放射科医师检查。
UNASSIGNED:我们分析了165名参与者的CXR结果:139例DS和26例RR-TB病例。大多数(n=118,71.7%)的参与者对HIV呈血清阴性。总的来说,5/165(3%)参与者的CXR正常。合并的参与者比例没有统计学上的显着差异(74.8%对88.5%;p=0.203),支气管肺炎混浊(56.1%对42.3%,p=0.207)和空洞(38.1%对46.2%,p=0.514),跨药物敏感性状态(DS与RRTB)。在感染艾滋病毒的参与者中,合并主要在DSTB组中的中肺区和RRTB组中的下肺区(42.5%对12.8%,p=0.66)。与RRTB的未感染HIV的参与者相比,RRTB的HIV感染参与者在统计学上显着较大的空腔大小(7.7±6.8cm对4.2±1.3cm,p=0.004)。
UNASSIGNED:我们观察到绝大多数参与者都有类似的CXR变化,无论药物敏感性状况如何。然而,HIV感染的RRPTB有较大的空洞。可以进一步研究区分HIV感染和未感染的RRTB的腔大小的诊断效用。
UNASSIGNED: Tuberculosis (TB) is one of the leading causes of death worldwide. Radiology has an important role in the diagnosis of both drug-sensitive (DS) and rifampicin-resistant (RR) pulmonary TB (PTB). This study aimed to compare the chest x-ray (CXR) patterns of microbiologically confirmed DS and RR PTB cases stratified by HIV serostatus in Uganda.
UNASSIGNED: We conducted a hospital-based retrospective study at the Mulago National Referral Hospital (MNRH) TB wards. All participants had a microbiologically confirmed diagnosis of PTB. CXR findings extracted included infiltrates, consolidation, cavity, fibrosis, bronchiectasis, atelectasis, and other non-lung parenchymal findings. All films were examined by two independent radiologists blinded to the clinical diagnosis.
UNASSIGNED: We analyzed CXR findings of 165 participants: 139 DS- and 26 RR-TB cases. The majority (n = 118, 71.7%) of the participants were seronegative for HIV. Overall, 5/165 (3%) participants had normal CXR. There was no statistically significant difference in the proportion of participants with consolidations (74.8% versus 88.5%; p = 0.203), bronchopneumonic opacities (56.1% versus 42.3%, p = 0.207) and cavities (38.1% versus 46.2%, p = 0.514), across drug susceptibility status (DS versus RR TB). Among HIV-infected participants, consolidations were predominantly in the middle lung zone in the DS TB group and in the lower lung zone in the RR TB group (42.5% versus 12.8%, p = 0.66). HIV-infected participants with RR TB had statistically significantly larger cavity sizes compared to their HIV uninfected counterparts with RR TB (7.7 ± 6.8 cm versus 4.2 ± 1.3 cm, p = 0.004).
UNASSIGNED: We observed that a vast majority of participants had similar CXR changes, irrespective of drug susceptibility status. However, HIV-infected RR PTB had larger cavities.The diagnostic utility of cavity sizes for the differentiation of HIV-infected and non-infected RR TB could be investigated further.