Authenticity is a positive force for adolescent development. Taking middle school students as the main research objects, this paper examines the causal mechanism between state authenticity (SA) and sense of meaning in life through two studies: the diary method and authenticity level increase experiment. In study 1, through the daily diary data tracking investigation of 130 middle school students in daily life situations, the basic psychological needs (BPNs) and satisfaction with life (SWL) play a chain mediating role between state authenticity and sense of daily meaning in life. State authenticity has a one-way prediction effect on sense of meaning in life. In study 2, 140 participants were randomly divided into two groups (experimental group and control group). Middle school students in the experimental group were activated to recall the authenticity experience events to enhance the level of personal authenticity, and it was found that the subjects reported a higher sense of meaning in life. This study reveals the causal mechanism between authenticity and sense of meaning of life, which has positive practical significance for exploring ways to enhance the sense of meaning of life of middle school students.

Materials Institute Lavoisier (MIL) metal organic frameworks (MOFs) are known for their potential to adsorb gaseous organic pollutants. This study explores the synergistic effects between the selection of central metals (e.g., titanium, iron, and aluminum) and the incorporation of -NH2 groups in terms of adsorption efficiency against gaseous formaldehyde (FA). A group of the pristine MIL MOFs is synthesized using three different metals (i.e., titanium, iron, and aluminum) and terephthalic acid along with their NH2 derivatives using 2-aminoterephthalic acid. Among the pristine forms, MIL-125(Ti) achieves the highest FA adsorption capacity (Q) of 26.96 mg g-1 and a partition coefficient (PC) of 0.0898 mol kg-1 Pa-1. Further, amination significantly improves the FA adsorption potential of NH2-MIL-125(Ti) with a Q value of 91.22 mg g-1 (PC = 0.3038 mol kg-1 Pa-1). In situ diffuse reflectance infrared Fourier-transform spectroscopy reveals that the FA adsorption of plain MILs should be governed primarily by physisorption. In contrast, FA adsorption of NH2-MILs appears to be regulated by both physisorption and chemisorption, while the latter being affected mainly through FA-NH2 interactions (Schiff base reactions). These findings provide valuable insights into the utility of aminated MIL sorbents, possibly toward the efficient management of indoor air quality.

OBJECTIVE: The ideal option of food for a newborn\'s nourishment has traditionally been human breast milk (HBM). Previous studies have demonstrated a connection between the length of exclusively breastfeeding and its preventive effects on several conditions in neonates. Considering the significance of HBM, the study aimed at detecting the expression of microRNA (miR126*, miR155, miR21, and miR29a) in the breast milk cell fraction of women with hypertension. This was a cohort study of 35 postpartum women.
METHODS: Five ml of milk was collected into a sterile container from patients in the morning on the second and third days after the labor. The collected milk has been centrifuged, total cellular RNA has been isolated from cell fraction from the collected milk, isolated RNA has been subject to qualitative and quantitative analysis, next reverse transcription has been conducted, followed by that, evaluation of the expression of the selected microRNA has been conducted using the synthesized cDNA. Finally, the tested microRNA\'s relative expression level has been calculated.
RESULTS: Among patients with hypertension, the analysis of cell fraction of breast milk reported lower mean expression of miR126*, miR155, miR21, and miR29a as compared to patients without hypertension. Strong and very strong positive correlation between the expression of miR126* and miR155, miR126* and miR21, miR155 and miR21, miR 155 and miR29a, and miR 21 and miR29a have been noted.
CONCLUSIONS: Comparing patients with and without hypertension, it has been noted that patients with hypertension had lower mean expression of miR126*, miR155, miR21, and miR29a.

Metal-organic frameworks (MOFs) are an emerging group of nanomaterials for successful biomedical applications in gene therapy. The most commonly biocompatible MOFs are zinc-based ZIFs, zirconium-based UiOs, and iron-based MILs. However, despite increasing applications, a comparative study to underscore the critical factors for determining effective gene delivery by such MOFs is lacking. Herein, we evaluate the potential of UiO-66 and MIL-88B and ZIF-8 for gene therapeutics delivery; revealing the comparative importance of ZIF-8. Cytotoxicity assays proved insufficient for selecting the ideal gene delivery MOF vehicle. Synthesis conditions such as ability of the MOF scaffold to envelop the gene during in-situ synthesis, post-treatment such as washing, and gene loading efficiency proved to be the critical factors in determining the favourable MOF from the material selection perspective. Rapid in-situ synthesis under physiological conditions, successful gene loading, and low concentration requirements favour ZIF MOFs as gene delivery vehicles. Impact on cellular physiology, metabolism, and architecture revealed neutrality of the delivery system; and relative effects on pro-inflammatory and anti-inflammatory cytokines suggest immunomodulatory impact.

OBJECTIVE: The study aims to raise medical specialists\' awareness regarding the severity of possible complications of levamisole administration, and demonstrate the role of accurate medical history collection in a differential diagnosis.
BACKGROUND: Levamisole, an anthelmintic drug with immunomodulatory effects, has long been used worldwide till the early 2000s, when its association with demyelinating leukoencephalopathy was established. However, in the developing countries, it is still widely used for the prevention and treatment of helminthic invasion in humans. The actual prevalence of levamisole-induced multiple inflammatory leukoencephalopathy (LEV-induced MIL) in Russia remains unknown, and therefore, the study of its frequency and characteristics is indisputably important.
OBJECTIVE: The objective of this study is to determine the clinical features and MRI findings of levamisole- induced MIL in the Russian population, and to analyse the frequency of diagnostic errors at the initial assessment.
METHODS: A single-center retrospective analysis of total 30 patients who were diagnosed with LEV- induced MIL and attended the Research Center of Neurology was conducted. Inclusion criteria were 1) clinically: acute or subacute polysymptomatic onset of neurological disturbances, 2) MRI: multifocal demyelinating lesion with no evidence of dissemination in time, 3) anamnestic data: levamisole exposure from 2 to 8 weeks before symptoms onset as well as monophasic disease course (absence of relapses according to follow up assessments up to 3 years).
RESULTS: Clinically, presentation with constitutional symptoms including headache, fever, fatigue and myalgia, focal motor disturbances and dysarthria prevailed in our cohort. On the brain MRI, multiple foci of demyelination with simultaneous gadolinium enhancement were observed. The link between neurological symptoms and levamisole intake has often been detected only during follow- up assessments. Patients were most often misdiagnosed with acute disseminated encephalomyelitis, stroke and multiple sclerosis. In most cases, LEV-induced MIL was successfully treated with intravenous corticosteroids and/or plasma exchange (PLEX), however, residual neurologic symptoms were preserved in some patients. Additionally, two detailed clinical cases of patients being initially misdiagnosed are presented in the article.
CONCLUSIONS: The differential diagnosis remains difficult for suspected cases of LEV-induced MIL that could lead to delayed therapy initiation, and consequently incomplete recovery. Growing evidence suggests that a single administration of levamisole even in low doses might potentially lead to severe neurological deficit or death. Therefore, changes in medication management policies are required in order to prevent the uncontrolled use of levamisole.

Resilience and meaning in life are significant indicators of psychological well-being and health, which are particularly important in the context of the COVID-19 pandemic. Therefore, they have been explored by a growing number of scientists. There has been a research gap, however, that fails to show that time perspectives also have a significant impact on the perception and building of different life aspects. The current study investigated the associations between resilience, time perspectives and meaning in life and examined the moderating role of time perspective in the relationship between resilience and meaning in life.
Participants of this cross-sectional study were 363 adults aged 18-70. Resilience Measurement Scale (SPP-25), the Zimbardo Time Perspective Inventory (ZTPI), and the Purpose in Life Questionnaire (PIL) were used.
The findings confirmed a positive relationship between resilience, meaning in life, and positive time perspectives (Present Hedonistic and Future) and a negative link with Past Negative and Present Fatalistic perspectives. The linear regression analyses showed that Past Negative and Past Positive perspectives significantly moderated the relationship between resilience and meaning in life. The moderating effect was also confirmed in the case of past time perspectives only.
The findings indicate the relevance of positive resources, such as resilience and positive perception of the past, in keeping the meaning in life. Understanding the effect of psychological strengths in the context of the pandemic time can be a key to providing intervention and therapeutic services fostering mental health and well-being.

Because the pollutants produced by human activities have destroyed the ecological balance of natural water environment, and caused severe impact on human life safety and environmental security. Hence the task of water environment restoration is imminent. Metal-organic frameworks (MOFs), structured from organic ligands and inorganic metal ions, are notable for their outstanding crystallinity, diverse structures, large surface areas, adsorption performance, and excellent component tunability. The water stability of MOFs is a key requisite for their possible actual applications in separation, catalysis, adsorption, and other water environment remediation areas because it is necessary to safeguard the integrity of the material structure during utilization. In this article, we comprehensively review state-of-the-art research progress on the promising potential of MOFs as excellent nanomaterials to remove contaminants from the water environment. Firstly, the fundamental characteristics and preparation methods of several typical water-stable MOFs include UiO, MIL, and ZIF are introduced. Then, the removal property and mechanism of heavy metal ions, radionuclide contaminants, drugs, and organic dyes by different MOFs were compared. Finally, the application prospect of MOFs in pollutant remediation prospected. In this review, the synthesis methods and application in water pollutant removal are explored, which provide ways toward the effective use of water-stable MOFs in materials design and environmental remediation.

BACKGROUND: To date, number of new and attractive materials have been applied in drug delivery systems (DDDs) to improve the efficiency of the treatment of cancers. Some problems like low stability, toxicity and weak ability of targeting have hampered most of materials for further applications in biomedicine. MIL(MIL = Materials of Institute Lavoisier), as a specific subclass of metal-organic frameworks (MOFs) owns more advantages than other subclass MOFs, such as better biodegradability and lower cytotoxicity. However, until now, systematic -s and analyses of Fe-based MIL on medical applications are rarely though the majority of documents discussed one research branch of the porous materials MOFs.
CONCLUSIONS: In this review, we have focussed mainly on the latest studies of applications, including bioimaging, biosensing, and antibacterial and drug delivery on Fe-based MIL. The existing shortcomings and future perspectives of the rapidly growing biomedical applications of Fe-based MIL materials addressing dosage and loading strategies issues are also discussed briefly, and further studies with the use of different therapies will be of great interest.
CONCLUSIONS: This article reviews the Fe-based MOFs design and biomedical application, including biosensing, bioimaging, antibacterial agent, and drug delivery in recent years.

Bone is a complex hierarchical material that can be characterized from the microscale to macroscale. This work demonstrates the application of an enhanced homogenization methodology to the multiscale structural analysis of a femoral bone. The use of this homogenization technique allows to remove subjectivity and reduce the computational cost associated with the iterative process of creating a heterogeneous mesh. Thus, it allows to create simpler homogenized meshes with its mechanical properties defined using information directly from the mesh source: the medical images. Therefore, this methodology is capable to accurately predict bone mechanical behavior in a fraction of the time required by classical approaches. The results show that using the homogenization technique, despite the differences between the used homogeneous and heterogeneous meshes, its mechanical behavior is similar. The proposed homogenization technique is useful for a multiscale modelling and it is computationally efficient.

Metal organic frameworks (MOFs) served as peroxidase-like artificial enzymes have been recently adopted for wide applications including therapy, pollution degradation, biosensing and so on. However, most of MOFs mimicking peroxidase cannot perform with the utmost efficiency under certain biological circumstances, such as bacterial infections. This is mainly because that the peroxidase-like MOFs exhibit highest activity at pH of 3-4, while bacterial infections cannot lower the environmental pH to the optimal value. This problem significantly restrains the therapy effect. Herein, self-activated cascade MOF/enzyme hybrid nanoreactors (MIL@GOx-MIL NRs) based on MIL (Materials of Institute Lavoisier) and GOx (Glucose oxidase) were successfully constructed through a two-step procedure. GOx was successfully loaded in the MIL shells and onto their surface as well. The GOx can catalyze the production of gluconic acid that reduces the pH value to around 4, at which the MIL@GOx-MIL NRs perform the highest cascade reaction activity. The continually produced hydrogen peroxide (H2O2) can be subsequently catalyzed by MIL NPs to generate highly toxic hydroxyl radicals (HO•) for antibacterial application. Thus, MIL@GOx-MIL NRs can significantly inhibit methicillin-resistant staphylococcus aureus (MRSA) growth and biofilm formation.