未经证实:已知131I-间碘苄基胍(MIBG)的心肌摄取减少是诊断帕金森病(PD)的重要特征。然而,单纯心肌MIBG显像的诊断准确性往往不能令人满意.最近的研究已经发现,在PD患者中主要唾液腺的MIBG摄取也降低。
UASSIGNED:为了评估主要唾液腺MIBG闪烁显像在PD中的诊断价值,并探讨心肌MIBG闪烁显像联合唾液腺MIBG闪烁显像在区分PD和非PD(NPD)中的潜在作用。
未经证实:对37名受试者进行了131I-MIBG闪烁显像。他们被分为PD组(N=18)和NPD组(N=19),根据临床诊断标准,DATPET和18F-FDGPET成像结果。唾液腺和心肌的图像被勾勒出来以计算MIBG摄取比。
UNASSIGNED:左腮腺和左颌下腺早期图像的组合在区分PD和NPD方面具有良好的性能,有了敏感性,特异性,精度为50.00、94.74和72.37%,分别。早期结合大唾液腺和心肌显像结果对AUC有较好的诊断价值,敏感性和特异性分别为0.877、77.78和94.74%,分别。同时,在延迟期内,AUC具有出色的诊断价值,敏感性和特异性分别为0.904、88.89和84.21%,分别。
未经证实:131I-MIBG唾液腺闪烁显像有助于PD的诊断和鉴别诊断。大唾液腺和心肌131I-MIBG闪烁显像的结合进一步提高了PD诊断的准确性。
UNASSIGNED: Decreased myocardial uptake of 131I-metaiodobenzylguanidine (MIBG) is known to be an important feature to diagnose Parkinson\'s disease (PD). However, the diagnosis accuracy of myocardial MIBG scintigraphy alone is often unsatisfying. Recent studies have found that the MIBG uptake of the major salivary glands was reduced in PD patients as well.
UNASSIGNED: To evaluate the diagnostic value of major salivary gland MIBG scintigraphy in PD, and explore the potential role of myocardial MIBG scintigraphy combined with salivary gland MIBG scintigraphy in distinguishing PD from non-PD (NPD).
UNASSIGNED: Thirty-seven subjects were performed with 131I-MIBG scintigraphy. They were classified into the PD group (N = 18) and the NPD group (N = 19), based on clinical diagnostic criteria, DAT PET and 18F-FDG PET imaging findings. Images of salivary glands and myocardium were outlined to calculated the MIBG uptake ratios.
UNASSIGNED: The combination of left parotid and left submandibular gland early images had a good performance in distinguishing PD from NPD, with sensitivity, specificity, and accuracy of 50.00, 94.74, and 72.37%, respectively. Combining the major salivary gland and myocardial scintigraphy results in the early period showed a good diagnostic value with AUC, sensitivity and specificity of 0.877, 77.78, and 94.74%, respectively. Meanwhile, in the delayed period yield an excellent diagnostic value with AUC, sensitivity and specificity of 0.904, 88.89, and 84.21%, respectively.
UNASSIGNED: 131I-MIBG salivary gland scintigraphy assisted in the diagnosis and differential diagnosis of PD. The combination of major salivary gland and myocardial 131I-MIBG scintigraphy further increased the accuracy of PD diagnosis.