UNASSIGNED:皮肤T细胞淋巴瘤(CTCL)是一种慢性和进行性疾病,对生活质量(QoL)有重大影响。
UNASSIGNED:描述不同阶段的疾病对经典真菌病患者的影响,嗜毛囊真菌病,和Sézary综合征对一般和皮肤特异性QoL的影响以及与瘙痒的关系。
UNASSIGNED:一项关于典型的真菌病患者的横断面队列研究,嗜毛囊真菌病,并进行了Sézary综合征。结果是Skindex-29得分,慢性皮肤病对日常生活的影响,包括视觉模拟评分瘙痒,RAND-12
未经批准:纳入了106例CTCL患者。与总的霉菌病组相比,Sézary综合征患者的Skindex-29评分明显更差.晚期疾病患者的症状评分在统计学上较高(P=0.007),功能正常(P=.002),和总分(P=.012)。瘙痒程度与Skindex-29总分密切相关(R=0.713,P<.001)。
UNASSIGNED:CTCL的不同阶段可以对通用和皮肤病学特异性QoL的多个领域产生显着影响。瘙痒与QoL密切相关,因此可以用作整体QoL指标。对QoL的影响,即使在早期疾病患者中,不应该被低估。
UNASSIGNED: Cutaneous T-cell lymphoma (CTCL) is a chronic and progressive disease that has a major impact on quality of life (QoL).
UNASSIGNED: To describe the impact of the different stages of disease in patients with classical mycosis fungoides, folliculotropic mycosis fungoides, and Sézary syndrome on generic- and dermatology-specific QoL and the relation with itch.
UNASSIGNED: A cross-sectional cohort study of patients with classical mycosis fungoides, folliculotropic mycosis fungoides, and Sézary syndrome was performed. Outcomes were the Skindex-29 score, Impact of Chronic Skin Disease on Daily Life which includes a visual analogue scale itch, and RAND-12.
UNASSIGNED: One hundred six patients with CTCL were included. Compared to the total mycosis fungoides group, patients with Sézary syndrome had significantly worse Skindex-29 scores. Patients with advanced disease had statistically higher scores for the symptom (P = .007), functioning (P = .002), and total score (P = .012). The degree of itching was strongly correlated with the total Skindex-29 score (R = 0.713, P < .001).
UNASSIGNED: The different stages of CTCL can have a significant effect on multiple domains of generic- and dermatology-specific QoL. Itch was strongly correlated with QoL and therefore can be used as an overall QoL indicator. The effect on QoL, even in patients with early-stage disease, should not be underestimated.