抗菌素耐药性的出现是一项重大的全球卫生挑战,并成为决策者的当务之急。在埃塞俄比亚,缺乏从一种健康角度提出多药耐药模式的科学研究。因此,一项系统评价和荟萃分析旨在确定人类细菌多药耐药性的汇总患病率,动物,食物,和环境来源。
■在本系统综述和荟萃分析中,在PubMed和Google学者中使用不同的关键字进行了电子搜索。在埃塞俄比亚所有地区进行的研究,从2015年到2020年在同行评审期刊上发表,包括英语全文。荟萃分析是在STATA版本14上进行的。使用随机效应模型分析了每种细菌的多药耐药性的汇总患病率;CochranQ统计量和I2统计量用于分析异质性,并在p<0.01时被认为是显着的。
■81项研究纳入系统评价和荟萃分析;53项人体研究,八项动物研究,和16个环境/食物研究。荟萃分析包括来自革兰氏阳性细菌的6种和来自革兰氏阴性细菌的13种。金黄色葡萄球菌53%(95CI:42-64%),凝固酶阴性葡萄球菌68%(95CI:53-82),假单胞菌属。73%(95CI:48-93%),大肠杆菌70%(95CI:61-78%),柠檬酸杆菌属。71%(95CI:54-87%),克雷伯菌属。68%(54-80%),肠杆菌属。67%(48-83%)和沙门氏菌。65%(95CI:48-81%)是来自两种或更多种来源的常见多重耐药细菌。
■在埃塞俄比亚,在大多数人类细菌物种中,MDR的合并患病率很高,动物,食物,和环境来源。葡萄球菌,肠杆菌科和假单胞菌的大多数成员,是涉及所有来源的标准MDR细菌种群。因此,应实施综合政策和干预措施,以减少MDR细菌的出现和传播,从而获得更好的动物和人类健康结果。
UNASSIGNED: The emergence of antimicrobial resistance is a major global health challenge and becoming an urgent priority for policymakers. There is a paucity of scientific studies presenting the multidrug resistance pattern from one health perspective in Ethiopia. Therefore, a systematic review and meta-analysis aimed to determine the pooled prevalence of multidrug resistance in bacteria from human, animal, food, and environmental sources.
UNASSIGNED: In this systematic review and meta-analysis, an electronic search was made in PubMed & Google scholar using different keywords. The studies conducted in all areas of Ethiopia, published from 2015 to 2020 in peer-reviewed journals, English full-length papers were included. The meta-analysis was done on STATA version 14. The pooled prevalence of multidrug resistance for each bacterium was analysed using the random-effects model; Cochran Q statistics and the I 2 statistic was used to analyse heterogeneity and considered significant at p < 0.01.
UNASSIGNED: 81 studies were included in the systematic review and meta-analysis; 53 human studies, eight animal studies, and 16 environments/food studies. The meta-analysis included six species from gram-positive bacteria and 13 from gram-negative bacteria. S. aureus 53% (95%CI: 42-64%), Coagulase negative Staphylococci 68%(95%CI:53-82), Pseudomonas spp. 73%(95%CI:48-93%), E. coli 70% (95%CI:61-78%), Citrobacter spp. 71%(95%CI:54-87%), Klebsiella spp. 68% (54-80%), Enterobacter spp. 67% (48-83%) and Salmonella spp. 65% (95%CI:48-81%) were the common multidrug-resistant species of bacteria from two or more sources.
UNASSIGNED: In Ethiopia, the pooled prevalence of MDR is high in most bacterial species from humans, animals, food, and environmental sources. Staphylococcus, most members of the Enterobacteriaceae and Pseudomonas, are the standard MDR bacterial population involving all sources. Therefore, integrated policy and intervention measures should be implemented to reduce the emergence and spread of MDR bacteria for better animal and human health outcomes.