背景:非结核分枝杆菌(NTM)是可能引起和/或复合人类呼吸道疾病的环境细菌。有一百多种NTM物种具有不同的致病性,因此,有必要描述每个物种面临风险的种群特征。
方法:人口统计学(年龄,性别,和居住状态)和2014年的微生物数据是从密西西比州提取的,密苏里州,和俄亥俄州的疾病监测系统。具有>50个报告的NTM物种被包括在分析中。病人性,年龄,并对以下每个NTM物种产生发病率:脓肿分枝杆菌,M.avium复合体(MAC),海鱼M,M.偶然性,M.gordonae,M.kansasii,粘液菌,还有PeregrinumM.
结果:按性别进行的分析表明,M.偶然性,M.gordonae,男性的发病率明显高于女性。年龄与几种特定NTM物种的患者比率无关,例如,龟甲。密西西比州的鸟分枝杆菌患者率最高,M.gordonae,M.kansasii,和M.chelonae。俄亥俄州的脓肿分枝杆菌发病率最高,粘液菌,还有PeregrinumM.在密苏里州观察到最高的M.fortuitum患者率。
结论:这项研究表明NTM感染在男性中更常见。对于所研究的大多数NTM,密西西比州的发病率最高。年龄不是某些NTM物种的强风险因素。
BACKGROUND: Nontuberculous mycobacteria (NTM) are environmental bacterium that may cause and/or compound respiratory diseases in humans. There are over a hundred NTM species with varying pathogenicity\'s Therefore, it is necessary to characterize the populations at risk for each species.
METHODS: Demographic (age, sex, and state of residence) and microbiological data from 2014 were extracted from Mississippi, Missouri, and Ohio disease surveillance systems. NTM species with > 50 reports were included in the analysis. Patient sex, age, and incidence rates were generated for each of the following NTM species: M. abscessus, M. avium complex (MAC), M. chelonae, M. fortuitum, M. gordonae, M. kansasii, M. mucogenicum, and M. peregrinum.
RESULTS: Analysis by sex showed that M. chelonae,M. fortuitum, M. gordonae,and M. kansasii had significantly higher rates in males than females. Age was not associated with patient rates for several specific NTM species e.g., M. chelonae. Mississippi had the highest patient\' rates for M. avium, M. gordonae, M. kansasii, and M. chelonae. Ohio had the highest patient\' rates for M. abscessus, M. mucogenicum, and M. peregrinum. The highest patient\'s rate for M. fortuitum was observed in Missouri.
CONCLUSIONS: This study showed that NTM infection occurred more frequently in males. The highest rates were observed in Mississippi for most of the NTMs studied. Age was not a strong risk factor for some of the NTM species.