■对假结核棒状杆菌的影响(C.假性结核)和发展的蜂窝织炎和/或脓肿形成与牛皮肤淋巴管炎在一定程度上是罕见的,所以关于伴随这种感染的生化变化的文献很少见。
■在这种情况下,本研究旨在筛选感染假结核分枝杆菌皮肤淋巴管炎对某些免疫分子释放的影响,器官功能,Baladi奶牛的氧化还原状态。
■来自El-Behira一家小型奶牛场的14头Baladi奶牛,埃及,被选中完成这项研究。细菌学培养确认后,其中7人因感染假结核分枝杆菌而出现皮肤病变(患病组),而其他人是健康的(健康组)。获得血清样本以评估某些临床病理参数的推定变化。
■血清分析显示,干扰素-γ和白介素-17的水平显着降低,β-防御素(β-防御素)和脂质运载蛋白-2的浓度显着降低。当与健康对照动物相比时,这些动物中白细胞介素-10的血清水平显著增加。同时,受影响的动物记录血清肝心酶水平显着升高,尿素,和肌酐以及血清氧化还原状态的紊乱。
■总而言之,感染假结核分枝杆菌牛可能会扰乱防御性免疫状态,身体器官功能,和动物的氧化还原状态。
UNASSIGNED: Affection with Corynebacterium pseudotuberculosis (C. pseudotuberculosis) and development of cellulitis and/or abscess formation with cutaneous
lymphangitis in cattle is rare to some extent, so literature about the biochemical changes that would accompany this infection is rare.
UNASSIGNED: In this context, the present study was designed to screen the effect of the infection with C. pseudotuberculosis cutaneous
lymphangitis on the release of some immune molecules, organ functions, and redox state in Baladi cows.
UNASSIGNED: Fourteen Baladi cows from a small dairy farm in El-Behira, Egypt, were selected to complete this study. After bacteriological culture confirmation, seven of them were found suffering from cutaneous lesions due to infection with C. pseudotuberculosis (Diseased group), while the others were healthy (Healthy group). Serum samples were obtained to evaluate the presumptive changes in some clinicopathological parameters.
UNASSIGNED: Serum analysis revealed a significant decrease in the levels of interferon-gamma and interleukin-17 as well as a significant decrement in the concentration of beta-defensin (β-defensin) and lipocalin-2. While serum level of interleukin-10 recorded a significant increase in these animals when compared to healthy control animals. Concurrently, the affected animals recorded a significant elevation in serum levels of hepato-cardiac enzymes, urea, and creatinine in addition to disturbance in the serum redox state.
UNASSIGNED: In conclusion, infection with C. pseudotuberculosis cattle may disturb the defensive immune state, body organ function, and redox state of the animals.