■探讨肿瘤异常蛋白在2型糖尿病合并原位肺腺癌患者中的应用价值。
■共140例2型糖尿病合并原位肺腺癌患者(A组),160例2型糖尿病患者(B组),从2021年11月至2022年12月,苏州大学附属第一医院胸外科纳入120名健康对照(C组)。
■A组的总胆固醇水平高于B组(p<0.05)和C组(p<0.01),B组高于C组(p<0.01)。胆固醇水平与肿瘤异常蛋白的比较结果相似,低密度脂蛋白胆固醇,三组间的糖化血红蛋白。A组甘油三酯水平高于B组和C组(均P<0.01)。A组的高密度脂蛋白胆固醇水平高于C组(p<0.01)。A组空腹血糖水平高于B组和C组(两者,p<0.01)。这些发现表明肿瘤异常蛋白,糖化血红蛋白,高密度脂蛋白胆固醇,空腹血糖是2型糖尿病合并原位肺腺癌患者的独立影响因素。
■因此,检测肿瘤异常蛋白水平可能有助于诊断2型糖尿病患者的原位肺腺癌。
研究发现肿瘤异常蛋白,糖化血红蛋白,高密度脂蛋白胆固醇,空腹血糖是2型糖尿病合并原位肺腺癌患者的独立影响因素。检测肿瘤异常蛋白水平可能有助于2型糖尿病患者原位诊断肺腺癌。
To investigate the application value of tumor abnormal protein in patients with type 2 diabetes mellitus complicated with lung adenocarcinoma in situ.
A total of 140 patients having type 2 diabetes mellitus complicated with lung adenocarcinoma in situ (Group A), 160 patients with type 2 diabetes mellitus (Group B), and 120 healthy controls (Group C) were enrolled in the Department of Thoracic Surgery of the First Affiliated Hospital of Soochow University from November 2021 to December 2022.
The total cholesterol level was higher in Group A than in Group B (p < 0.05) and Group C (p < 0.01), and it was higher in Group B than in Group C (p < 0.01). The comparison results of cholesterol level were similar to those of tumor abnormal protein, low-density lipoprotein cholesterol, and glycosylated hemoglobin among the three groups. The triglyceride level was higher in Group A than in Group B and Group C (both p < 0.01). Group A had a higher level of high-density lipoprotein cholesterol than Group C (p < 0.01). The fasting plasma glucose level was higher in Group A than in Group B and Group C (both, p < 0.01). These findings indicated that tumor abnormal protein, glycosylated hemoglobin, high-density lipoprotein cholesterol, and fasting plasma glucose were independent factors for patients having type 2 diabetes mellitus complicated with lung adenocarcinoma in situ.
Therefore, detecting tumor abnormal protein levels may help diagnose lung adenocarcinoma in situ in patients with type 2 diabetes mellitus.
The study found that tumor abnormal protein, glycosylated hemoglobin, high-density lipoprotein cholesterol, and fasting plasma glucose were independent factors for patients having type 2 diabetes mellitus complicated with lung adenocarcinoma in situ. Detecting tumor abnormal protein levels may help diagnose lung adenocarcinoma in situ in patients with type 2 diabetes mellitus.