背景:评估1型糖尿病(T1D)成年人中低热量甜味剂(LCS)的使用及其对生活质量(QOL)的影响。
方法:在这个单一中心,对532名T1D成人的横断面调查研究,食品相关QOL(FRQOL),LCS特定问卷(LCSSQ),糖尿病自我管理问卷(DSMQ),食物频率问卷(FFQ),对糖尿病依赖性QOL(AddQOL)的审计,1型糖尿病和生活(T1DAL)问卷通过RedCAP,一个安全的,符合HIPAA标准的基于Web的应用程序。比较了上个月使用LCS的成年人(最近的用户)和其他人(非用户)的人口统计和得分。结果根据年龄进行了调整,性别,糖尿病持续时间和其他参数。
结果:在532名参与者中(平均年龄36±13,69%为女性),99%之前听到过LCS,68%的人在上个月使用了它们,73%报告使用LCS时血糖控制更好,63%报告使用LCS时没有健康问题。最近的LCS使用者年龄较大,糖尿病持续时间较长,并发症较多(高血压,或任何并发症)比非用户。然而,A1c,AddQOL,T1DAL,最近的LCS用户和非用户之间的FRQOL得分没有显着差异。DSMQ分数,DSMQ管理,饮食,健康护理评分在两组之间没有差异;然而,近期LCS使用者的体力活动评分低于非使用者(p=0.001).
结论:大多数患有T1D的成年人使用过LCS,并认为使用LCS改善了他们的QOL和血糖控制;然而,这些没有用问卷进行验证。除了最近的LCS用户与T1D用户之间的DSMQ体育锻炼外,QOL问卷没有差异。然而,更多需要提高生活质量的患者可能正在使用LCS;因此,暴露和结果之间的关联可以是双向的。
BACKGROUND: To evaluate use of low-calorie sweeteners (LCS) among adults with type 1 diabetes (T1D) and its impact on quality of life (QOL).
METHODS: In this single center, cross-sectional survey study with 532 adults with T1D, Food related QOL (FRQOL), LCS specific questionnaire (LCSSQ), Diabetes Self-Management Questionnaire (DSMQ), Food Frequency Questionnaire (FFQ), Audit of Diabetes-Dependent QOL (AddQOL), Type 1 Diabetes and Life (T1DAL) questionnaires were administered through RedCAP, a secure, HIPAA-compliant web-based application. Demographics and scores of adults who used LCS in last month (recent users) and others (non-users) were compared. Results were adjusted for age, sex, diabetes duration and other parameters.
RESULTS: Of 532 participants (mean age 36 ± 13, 69% female), 99% heard LCS before, 68% used them in the last month, 73% reported better glucose control with LCS use and 63% reported no health concerns about LCS use. Recent LCS users were older and had a longer diabetes duration and more complications (hypertension, or any complication) than non-users. However, A1c, AddQOL, T1DAL, FRQOL scores did not differ significantly between recent LCS users and non-users. DSMQ scores, DSMQ management, diet, health care scores did not differ between two groups; however, recent LCS users had lower physical activity score than non-users (p = 0.001).
CONCLUSIONS: Most of the adults with T1D have used LCS and perceived that LCS use improved their QOL and glycemic control; however, these were not verified with questionnaires. There was no difference in QOL questionnaires except DSMQ physical activity between recent LCS users and not users with T1D. However, more patients in need to increase their QOL may be using LCS; therefore, associations between the exposure and outcome can be bi-directional.