背景:我们旨在使用2019年全球疾病负担(GBD)研究记录2000年至2019年全球和不同世卫组织地区低BMD暴露的现状以及可归因负担趋势。
方法:我们回顾了低BMD和残疾调整生命年(DALYs)的特定性别区域汇总暴露值(SEV),残疾生活年(YLDs),多年的生命损失(YLL),和死亡归因于低BMD。我们比较了世卫组织的不同地区,年龄类别,和性别根据GBD2019报告。
结果:2019年,全球年龄标准化的低骨密度SEV估计为女性20.7%,男性11.3%。非洲的女性(28.8%[22.0至36.3])和男性(16.8%[11.5至23.8])的低BMD年龄标准化SEV最高。在欧洲女性(14.7%[9.9至21.0])和男性(8.0%[4.3至13.4])中观察到最低的SEV。全球年龄标准化DALY率的提高趋势,死亡,在2000年至2019年期间观察到YLL;然而,绝对数字增加,全球YLD(70.9%)和死亡数字(67.6%)增幅最高.在所有指数中,东南亚地区的年龄标准化率最高。
结论:总体而言,在东南亚地区,低骨密度造成的负担最高.了解低BMD的SEV和归因负担可以提高医疗保健决策者采取适当策略进行早期筛查的意识。以及预防跌倒和脆性骨折及其随之而来的发病率和死亡率的策略。
UNASSIGNED: We aimed to document the current state of exposure to low bone mineral density (BMD) and trends in attributable burdens between 2000 and 2019 globally and in different World Health Organization (WHO) regions using the Global Burden of Disease (GBD) study 2019.
UNASSIGNED: We reviewed the sex-region-specific summary exposure value (SEV) of low BMD and the all-ages numbers and age-standardized rates of disability-adjusted life years (DALYs), years lived with disability (YLDs), years of life lost (YLLs), and deaths attributed to low BMD. We compared different WHO regions (Africa, the Eastern Mediterranean Region, Europe, Region of the Americas, Southeast Asia, and Western Pacific), age categories, and sexes according to the estimates of the GBD 2019 report.
UNASSIGNED: The global age-standardized SEV of low BMD is estimated to be 20.7% in women and 11.3% in men in 2019. Among the WHO regions, Africa had the highest age-standardized SEV of low BMD in women (28.8% (95% uncertainty interval 22.0-36.3)) and men (16.8% (11.5-23.8)). The lowest SEV was observed in Europe in both women (14.7% (9.9-21.0)) and men (8.0% (4.3-13.4)). An improving trend in the global rate of DALY, death, and YLL was observed during 2000-2019 (-5.7%, -4.7%, and -11.9% change, respectively); however, the absolute numbers increased with the highest increase observed in global YLD (70.9%) and death numbers (67.6%). Southeast Asia Region had the highest age-standardized rates of DALY (303.4 (249.2-357.2)), death (10.6 (8.5-12.3)), YLD (133.5 (96.9-177.3)), and YLL (170.0 (139-197.7)).
UNASSIGNED: Overall, the highest-burden attributed to low BMD was observed in the Southeast Asia Region. Knowledge of the SEV of low BMD and the attributed burden can increase the awareness of healthcare decision-makers to adopt appropriate strategies for early screening, and also strategies to prevent falls and fragility fractures and their consequent morbidity and mortality.